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JCI online early table of contents: Dec. 19, 2011

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TITLE: Correlation of rare coding variants in the gene encoding human glucokinase regulatory protein with phenotypic, cellular, and kinetic outcomes

Francis S. Collins
National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
Phone: 301-496-2433; Fax: 301-402-2700; E-mail:

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ENDOCRINOLOGY: Sugar overload: refining the role of the hormone GLP-1

How does the body deal with the sudden influx of sugar that it receives after we have eaten a meal? The answers to this question not only provide insight into how the body works but can yield information that could be useful in the development of new therapeutic approaches to treating type 2 diabetes, a chronic disease characterized by high levels of sugar (glucose) in the blood. In relation to this question, Daniel Drucker and colleagues, at the University of Toronto, Toronto, have investigated in detail the function of the hormone GLP-1, which is produced by cells in the gut after food ingestion. They find that GLP-1 acts directly on cells in the pancreas to control the production of insulin, the hormone that controls blood glucose levels. These data refine our understanding of the complexity of the response to sudden sugar influx.

TITLE: Pancreatic GLP-1 receptor activation is critical for incretin control of glucose metabolism in mice

Daniel J. Drucker
Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Phone: 416-361-2661; Fax: 416-361-2669; E-mail:

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Contact: Karen Honey
Journal of Clinical Investigation

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