Navigation Links
JCI online early table of contents: Dec. 19, 2011
Date:12/19/2011

a-cell survival. Importantly, in a mouse model of type 1 diabetes, production of an active heparan sulfatedegrading protein (heparanase) was associated with beta-cell destruction, while treatment with an inhibitor of heparanase protected the mice from disease. Simeonovic and colleagues therefore suggest that maintaining expression of heparan sulfate on beta-cells could provide a new approach to preventing the development of type 1 diabetes.

TITLE: Heparan sulfate and heparanase play key roles in mouse beta-cell survival and autoimmune diabetes

AUTHOR CONTACT:
Charmaine J. Simeonovic
The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.
Phone: 61-2-6125-4709; Fax: 61-2-6125-2595; E-mail: Charmaine.Simeonovic@anu.edu.au.

View this article at: http://www.jci.org/articles/view/46177?key=f37890b794c1c03854d8

GENETICS: Linking genetic variation to changes in protein function

Many common human diseases, including type 2 diabetes, are thought to arise as a result of both genetic and environmental factors. It is hoped that defining the genetic component of such diseases could provide not only insight into cause but also candidate therapeutic approaches. In this context, variants of the GCKR gene have been suggested to be clinically important, with some linked to type 2 diabetes. However, how these variants affect protein function and influence disease has not been determined. Now, a team of researchers led by Francis Collins, at the National Human Genome Research Institute, Bethesda, has characterized the function of a large number of variants of the GCKR gene. The data generated indicate that the majority of the GCKR variants tested do affect protein function and are likely to provide an important genetic component of several clinica
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. Online guide helps health organizations adopt electronic health records
2. JCI online early table of contents: Dec. 12, 2011
3. JCI online early table of contents: Nov. 21, 2011
4. Bullying Moves From Online to Text-Messaging: Study
5. JCI online early table of contents: Nov. 14, 2011
6. JCI online early table of contents: Nov. 7, 2011
7. Online Forums Can Help Women Cope With Pregnancy Loss
8. Parents who go online for pediatric health information are open to doctors website recommendations
9. Survey reveals reasons doctors avoid online error-reporting tools
10. Penn-developed online informed consent tool could boost number of patients in cancer clinical trials
11. New online learning module gives children of domestic violence a voice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/23/2014)... 23, 2014 Cardiomyopathy (heart muscle ... of the myocardium (the heart muscle) for any ... are dyspnea (breathlessness) and peripheral edema (swelling of ... risk of dangerous forms of irregular heart beat ... of cardiomyopathy is dilated cardiomyopathy. , Clinical trial ...
(Date:8/23/2014)... York, New York (PRWEB) August 23, 2014 ... stemming from the 2012 GranuFlo and NaturaLyte dialysis ... multidistrict litigation underway in U.S. District Court, District ... an updated docket report issued by the U.S. ... 15th, at least 2,028 claims are pending in ...
(Date:8/23/2014)... (PRWEB) August 23, 2014 "When men ... comes into contact with the dirty water inside the ... seat itself," said one of two inventors from Naugatuck, ... germs, we developed this protective device." , They developed ... toilet surfaces, including the water, bowl and seat. This ...
(Date:8/23/2014)... 2014 On Monday, August 18th, ... breach suffered by Community Health Systems, which operates ... 4.5 million records containing Personally Identifiable Information (PII) like ... Mandiant, who was engaged to investigate the incident, the ... group of cyber attackers based in China, who they ...
(Date:8/23/2014)... August 23, 2014 Pixel Film Studios, a ... today the release of ProIntro Vol.3, a customizable title ... and professional tile just by dragging ProIntro Vol.3 in their ... Vol.3 is a definite time saver and i think our ... with 30 beautifully designed titles made with Final Cut Pro ...
Breaking Medicine News(10 mins):Health News:Cardiomyopathy (Heart Muscle Disease) Therapeutics Clinical Trials Market 2014 Analysis in a New Report Available at MarketOptimizer.org 2Health News:Cardiomyopathy (Heart Muscle Disease) Therapeutics Clinical Trials Market 2014 Analysis in a New Report Available at MarketOptimizer.org 3Health News:Cardiomyopathy (Heart Muscle Disease) Therapeutics Clinical Trials Market 2014 Analysis in a New Report Available at MarketOptimizer.org 4Health News:GranuFlo Lawsuits Mount in Federal Litigation, as Filings Surpass 2,000, Bernstein Liebhard LLP Reports 2Health News:GranuFlo Lawsuits Mount in Federal Litigation, as Filings Surpass 2,000, Bernstein Liebhard LLP Reports 3Health News:GranuFlo Lawsuits Mount in Federal Litigation, as Filings Surpass 2,000, Bernstein Liebhard LLP Reports 4Health News:This Time Prominent Hospital Group Falls Prey to Hackers Believed to be Based in China 2Health News:This Time Prominent Hospital Group Falls Prey to Hackers Believed to be Based in China 3Health News:This Time Prominent Hospital Group Falls Prey to Hackers Believed to be Based in China 4Health News:A new plugin was announced today, ProIntro Vol.3 from Pixel Film Studios for Final Cut Pro X 2
... and binge eating , MONDAY, May 10 (HealthDay News) ... the risk of impulse control disorders, such as problem ... In a new study that included 3,090 patients being ... the United States and Canada, the researchers found that ...
... ... Health Services, Inc. (CV10-2011), asserts that Gentiva, which employs some 30,000 health care workers, treats ... FLSA and refuses to pay these employees for all hours worked. , ... New York, NY (PRWEB) May 10, 2010 -- ...
... . Montreal, May 10, 2010 As fewer people ... among North American youth. A study published in the journal ... Montreal had used waterpipes (also known as shishas or hookahs) in ... due in part to perceptions that they are safer than cigarettes. ...
... Nurse staffing ... newly adopted U.S. Health Care Reform legislation. Current healthcare reform legislation indicates that more ... , ... (PRWEB) May 10, 2010 -- Nurse staffing agency, FlexRN, announces its plans to help agency ...
... treatment even when pulmonary disease looks stable, researchers ... of chronic obstructive pulmonary disease (COPD) leads to increased ... study finds. , British researchers looked at 25,857 COPD ... and 633 ischemic strokes (blockage of blood flow to ...
... from the Georgetown Lombardi Comprehensive Cancer Center at Georgetown ... therapy to "rescue" treatment sensitivity to fulvestrant in estrogen ... on May 15, 2010 as the cover story of ... common second-line therapy for women whose cancer progresses following ...
Cached Medicine News:Health News:Parkinson's Drugs Tied to Compulsive Behaviors 2Health News:Martin & Jones Announces Class Action Lawsuit Against Major Employer, Claims Thousands of Visiting Nurses Illegally Denied Overtime Pay 2Health News:Martin & Jones Announces Class Action Lawsuit Against Major Employer, Claims Thousands of Visiting Nurses Illegally Denied Overtime Pay 3Health News:FlexRN Nurse Staffing Agency Prepares Nurses for Demands of Latest Health Care Reform 2Health News:Researchers discover new way to 'rescue' treatment sensitivity of breast cancer cells 2
(Date:8/22/2014)... 22, 2014 Research ... addition of the  "Global Operating Room Equipment ...      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,An operating ... environment in a healthcare facility used to ... technically advanced equipment, which ensures patient care ...
(Date:8/22/2014)... /CNW/ - On Aug. 20, at its annual meeting ... Association (CMA) voted on and approved a delegate resolution ... cannabis. Bedrocan Cannabis Corp., a leading Canadian licensed producer ... The CMA is quite right to point ... any plant material, including medicinal cannabis. While some patients, ...
(Date:8/22/2014)... , Aug. 22, 2014 Research and ... "Global and Chinese Intravenous Catheter Industry Report 2014" ... and Chinese Intravenous Catheter Industry Report 2014 is a ... the global intravenous catheter industry with a focus on ... overview of the industry including definitions, classifications, applications and ...
Breaking Medicine Technology:Global Operating Room Equipment Market 2014-2018: Key Vendors are Getinge, STERIS, Stykron and TRUMPF Medical Systems 2Bedrocan Canada Statement Regarding Canadian Medical Association Motion on Smoking Marijuana 2Global and Chinese Intravenous Catheter Industry Report 2014 2
... 2, 2012 CVS Caremark Corporation (NYSE: CVS ) ... months ended March 31, 2012. (Logo: http://photos.prnewswire.com/prnh/20090226/NE75914LOGO ... , Net revenues increased 19.9% to a record $30.8 ... , Retail Pharmacy segment same stores sales increased ...
... Ill., May 2, 2012  Celebrity chef Spike Mendelsohn knows all ... – especially for a person with acid reflux disease (ARD). ... Spike has also had to learn how to turn down ... awareness and understanding about the importance of managing heartburn symptoms ...
Cached Medicine Technology:CVS Caremark Reports Record First Quarter Results 2CVS Caremark Reports Record First Quarter Results 3CVS Caremark Reports Record First Quarter Results 4CVS Caremark Reports Record First Quarter Results 5CVS Caremark Reports Record First Quarter Results 6CVS Caremark Reports Record First Quarter Results 7CVS Caremark Reports Record First Quarter Results 8CVS Caremark Reports Record First Quarter Results 9CVS Caremark Reports Record First Quarter Results 10CVS Caremark Reports Record First Quarter Results 11CVS Caremark Reports Record First Quarter Results 12CVS Caremark Reports Record First Quarter Results 13CVS Caremark Reports Record First Quarter Results 14CVS Caremark Reports Record First Quarter Results 15CVS Caremark Reports Record First Quarter Results 16Chef Spike Mendelsohn Dishes on How to Turn Down the Heat on Acid Reflux Disease 2Chef Spike Mendelsohn Dishes on How to Turn Down the Heat on Acid Reflux Disease 3Chef Spike Mendelsohn Dishes on How to Turn Down the Heat on Acid Reflux Disease 4Chef Spike Mendelsohn Dishes on How to Turn Down the Heat on Acid Reflux Disease 5
... shoulder immobilization and ... motion for glenohumeral ... tears, and acromioclavicular ... brace is designed ...
... Bird and Cronin, Inc. ... of Patient Footwear, Orthopedic ... Care Products. Our products ... quality and available in ...
... and Cronin, Inc. is ... Patient Footwear, Orthopedic Softgoods, ... Products. Our products are ... and available in the ...
... Aspen® LSO braces provide pain relief, ... leads to better patient outcomes. ,The Aspen® ... and comfortable support. When firmly tightened, using ... to regain a significant degree of functional ...
Medicine Products: