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JCI online early table of contents: Dec. 19, 2011
Date:12/19/2011

factor link to breast cancer

The growth factor IGF-1 has been implicated in the development of breast cancer. A team of researchers led by Robin Fuchs-Young, at The University of Texas M.D. Anderson Cancer Center, Smithville, has now demonstrated in mice that the level of expression of the protein estrogen receptor alpha (ER-alpha) on mammary gland cells influences whether IGF-1 can promote breast cancer. Fuchs-Young and colleagues therefore suggest that prepubertal and postmenopausal women are likely to be most susceptible to the potential breast cancerpromoting effects of increased levels of IGF-1, since these are the times in a woman's life when ER-alpha levels are highest.

TITLE: Developmental stage determines estrogen receptor alpha expression and nongenomic mechanisms that control IGF-1 signaling and mammary proliferation

AUTHOR CONTACT:
Robin Fuchs-Young
The University of Texas M.D. Anderson Cancer Center, Smithville, Texas, USA.
Phone: 512-237-9547; Fax: 512-237-6440; E-mail: rfyoung@mdanderson.org.

View this article at: http://www.jci.org/articles/view/42204?key=7e26e09e330e04540afb

METABOLIC DISEASE: Heparan sulfate: protecting the cells destroyed in type 1 diabetes

Type 1 diabetes is a lifelong disease characterized by high levels of sugar (glucose) in the blood. It is caused by the patient's immune system attacking and destroying the cells in their pancreas that produce the hormone insulin, which regulates blood glucose levels. Surprisingly, little is known about the mechanisms regulating the sensitivity and resistance of these cells, which are known as beta-cells, to immune system attack. Now, Charmaine Simeonovic and colleagues, at The Australian National University, Australia, have determined that the molecule heparan sulfate is essential for mouse bet
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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