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JCI online early table of contents: Dec. 19, 2011
Date:12/19/2011

he authors therefore suggest that other TGF-betatargeted therapeutics might also be viable candidates for the treatment of COPD.

TITLE: Angiotensin receptor blockade attenuates cigarette smokeinduced lung injury and rescues lung architecture in mice

AUTHOR CONTACT:
Enid Neptune
Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Phone: 410-955-4176; Fax: 410-955-0036; E-mail: eneptune@jhmi.edu.

View this article at: http://www.jci.org/articles/view/46215?key=1757af37800194593ae0

ONCOLOGY: A full TANC(1) needed to drive rhabdomyosarcoma

Rhabdomyosarcoma (RMS) accounts for 5% of all new pediatric cancers. In some patients, RMS is caused by a genetic event that gives rise to a fusion protein (PAX-FOXO1) that drives the development of the cancer. Rene Galindo and colleagues, at the University of Texas Southwestern Medical Center, Dallas, have now generated data in Drosophila and mammalian models that provide new insight into the molecular mechanisms by which PAX-FOXO1 drives the development of cancer. These data, which indicate a key role for the protein TANC1 in RMS driven by PAX-FOXO1, have identified new avenues of research for those seeking to develop candidates for targeted RMS therapy.

TITLE: Drosophila and mammalian models uncover a role for the myoblast fusion gene TANC1 in rhabdomyosarcoma

AUTHOR CONTACT:
Rene L. Galindo
University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA.
Phone: 214-648-4116; Fax: 214-648-4070; E-mail: rene.galindo@utsouthwestern.edu.

View this article at: http://www.jci.org/articles/view/59877?key=d24a5f9b7050c9b5a16b

ONCOLOGY: Growth
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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