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JCI online early table of contents: Dec. 12, 2011
Date:12/12/2011

system, providing potential targets for preventing unwanted immune system suppression.

TITLE: A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1

AUTHOR CONTACT:
Leo Koenderman
University Medical Center Utrecht, Utrecht, The Netherlands.
Phone: 31-88-7557255; Fax: 31-88-7555415; E-mail: l.koenderman@umcutrecht.nl.

View this article at: http://www.jci.org/articles/view/57990?key=ffff831d2c7a509bd694

IMMUNOLOGY: Numbers of immune first responders kept constant by LXRs

One of the first immune cells to respond to an invading microbe is the neutrophil. Numbers of these cells are tightly regulated because of their importance as a first responder. In healthy individuals, more than 1 109 neutrophils per kilogram body weight are released from the bone marrow every day; an equivalent number must be cleared from the circulation to ensure numbers remain constant. A team of researchers led by Steven Bensinger and Peter Tontonoz, at UCLA, Los Angeles has now determined that proteins known as LXRs are key regulators of neutrophil clearance and production in mice and identified the molecular pathways by which the LXRs do so. As dysregulation of neutrophil clearance has been implicated in the development of lupus, future studies will focus on determining whether modulating LXR signaling can modify disease in animal models of lupus.

TITLE: Coordinate regulation of neutrophil homeostasis by liver X receptors in mice

AUTHOR CONTACT:
Steven J. Bensinger
David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA.
Phone: 310-825-9885; Fax: 310-267-6267; E-mail: sbensinger@mednet.ucla.edu.

Peter Tontonoz
David Geffen
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
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