Navigation Links
JCI online early table of contents: Dec. 1, 2010
Date:12/1/2010

articles/view/39828?key=0bb497688c5428a246bd


HEPATOLOGY: The proteins FXR and SHP work together to regulate bile acid levels

Bile acids, which are made in the liver, are involved in numerous biological processes, including digestion of fats, liver regeneration, and energy expenditure. Levels of bile acid are tightly regulated by a feedback loop. Current models place the protein FXR upstream of SHP in a linear pathway within this feedback loop. Now, a team of researchers, led by David Moore, at Baylor College of Medicine, Houston, has shown that in mice FXR and SHP act in parallel within the feedback loop that regulates bile acid levels. Of particular interest was the observation that mice lacking both FXR and SHP showed substantially more severe defects in regulation of bile acid levels than did mice lacking either of the proteins alone. Furthermore, as mice lacking both FXR and SHP developed cholestasis (the accumulation of bile acids in the liver) and liver injury at just 3 weeks of age, the authors suggest that these animals could provide a model for juvenile onset cholestasis, a term that encompasses several genetic diseases including progressive familial intrahepatic cholestasis.

TITLE: Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis

AUTHOR CONTACT:
David D. Moore
Baylor College of Medicine, Houston, Texas, USA.
Phone: 713.798.3313; Fax: 713.798.3017; E-mail: moore@bcm.edu.

View this article at: http://www.jci.org/articles/view/42846?key=061626916eb46a68a308


HEPATOLOGY: Uncovering the in vivo function of the protein Fbxw7 in the liver

Uncovering the in vivo function of the protein Fbxw7 has been difficult because mice lacking Fbxw7 die in utero. However, by selectively deleting Fbxw7 in
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10

Related medicine news :

1. TheReliefPlace.com Launches Online Store “The Relief Shop” - What Does this Medical Supply Store Carry and How Can They Help You?
2. Web Content Management Enables Government Transparency, Participation, and Collaboration Online
3. DavisPTnetwork Partners with the New York Physical Therapy Association to Provide Online Continuing Education
4. PERSONALABS Offers Discounted Healthy Heart Online Blood Tests in February
5. Pharmahelper Pleased To Recognize Online Pharmacy Practice Standards Announced By Google Adwords
6. Online Dating Reinvents Itself with the Recent Roll-Out of Teacherhookup.com, a Free Website that Focuses on a Person's Career in Education!
7. EdenHome.com Adds Aventura Organic Clothes to Site and Announces Largest Online Selection of Stylish Organic Clothes for Men, Women and Children
8. Fire Protection Online Resolves Safety Concerns with CO2 Fire Extinguishers
9. JCI online early table of contents: Feb. 15, 2010
10. Fitness Trend Towards Online Personal Training Gets Real-World Weight Loss Results on FitOrbit.com
11. New Online Store Makes Buying Cosmetics a Healthy Choice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... (PRWEB) July 11, 2014 Global enterprises ... services to outsource day-to-day management activities. Managed services offer ... additional expenses. The economic slowdown resulted into rising operational ... and expenses is considered to be the global market ... future. , The global managed services market is estimated ...
(Date:7/11/2014)... HOUSTON (July 10, 2014) Obese and ... from their health care providers, according to new ... Center at Houston (UTHealth). , National guidelines state ... on the importance of maintaining a healthy weight. ... events are the leading cause of line-of-duty deaths ...
(Date:7/11/2014)... (HealthDay News) -- Prostate cancer patients are more likely ... treatment and die sooner if they also have depression, ... more than 41,200 American men who were diagnosed with ... them through 2009. Nearly 1,900 of the patients had ... their prostate cancer was discovered. "Men with intermediate- ...
(Date:7/11/2014)... Europe is one of the largest ... hence, irrigated land area. The agricultural sector is a ... around 30.0% of the total water use. The scale ... southern region, but far from negligible in most northern ... over 60.0% of the water use in most countries, ...
(Date:7/11/2014)... a history of hazardous or binge drinking reduced their ... mobile phone text messages following a visit to the ... in Annals of Emergency Medicine (" A ... Patients: A Randomized Clinical Trial "). , "Each day ... to 24 visit ERs and up to half have ...
Breaking Medicine News(10 mins):Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 2Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 3Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 4Health News:Depression May Make It Harder to Beat Prostate Cancer 2Health News:Europe Micro Irrigation System Market Driven by Growing Environmental Concerns and Decreasing Water Availability - New Report by MicroMarket Monitor 2Health News:Europe Micro Irrigation System Market Driven by Growing Environmental Concerns and Decreasing Water Availability - New Report by MicroMarket Monitor 3Health News:Text message medicine: Texts from the ER can reduce binge drinking 2
... men who smoke had less risk of undergoing total joint ... that men who were overweight, or who engaged in vigorous ... this study are now available in Arthritis & Rheumatism ... College of Rheumatology (ACR). Research has shown that ...
... , THURSDAY, July 7 (HealthDay News) -- Suicide ... financial crisis, while road deaths decreased, according to researchers. ... percent relative increase) between 2007 and 2009. At the same ... in suicide rates seen in EU countries before 2007. ...
... belief, so-called hypoallergenic dogs do not have lower household allergen ... study by Henry Ford Hospital researchers who sought to evaluate ... home than other dogs. Hypoallergenic dogs are believed to produce ... findings are to be published online this month in the ...
... and treatment of pediatric leukemia at St. Jude Children,s Research ... M. Stratton Medal from the American Society of Hematology (ASH). ... fight against this blood cancer during the past three decades. ... of Grune and Stratton, the medical publishing house that first ...
... be reached in time to avert an unprecedented suspension of ... Medicaid and other federal health programs," Virginia Hood, MBBS, ... told the president, vice president and Congressional leaders today. ... legislation to increase the debt ceiling linked to an agreement ...
... Kathleen Doheny HealthDay Reporter , THURSDAY, July ... dignity therapy helped terminally ill patients improve their quality ... changing how their family sees and appreciates them, according ... however, ease those distressed by dying, as the researchers ...
Cached Medicine News:Health News:Male smokers less likely to need joint replacement surgery of hip or knee 2Health News:Europe's Suicides Up, Road Deaths Down After Economy Tanked 2Health News:Study: Hypoallergenic dogs not less allergic than other dogs 2Health News:Ching-Hon Pui, M.D., honored by the American Society of Hematology for work in childhood cancer 2Health News:Debt ceiling agreement 'essential' to prevent disruption of care for Medicare & Medicaid patients 2Health News:Debt ceiling agreement 'essential' to prevent disruption of care for Medicare & Medicaid patients 3Health News:Special Talk Therapy Seems to Help Dying Patients 2Health News:Special Talk Therapy Seems to Help Dying Patients 3
(Date:7/11/2014)... 2014 According to a new ... Market (Endoscopes, Endoscopic Operative Devices, and Visualization Systems) - ... 2013-2019" the global endoscopy devices market was valued at ... grow at a CAGR of 6.8% from 2013 to ... billion in 2019. Browse the full Endoscopy ...
(Date:7/10/2014)... India , July 11, 2014  Major ... treatment of cancer are being highlighted in a ... Mumbai from 10-12 July, 2014.  Renowned national ... to share best practices and exchange knowledge on ... precise, accurate and efficient. The ...
(Date:7/10/2014)...  RESMED INC. (NYSE: RMD ) today announced ... ended June 30, 2014 results on Thursday, July 31, 2014, ... release with ResMed,s results will be issued after 1:00 p.m. ... to discuss operating results and future outlook. The ... Pacific Time and the live webcast of the call can ...
Breaking Medicine Technology:Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 3Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 4Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 5Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 6Improving quality and access to advanced cancer care in India and South Asia 2Improving quality and access to advanced cancer care in India and South Asia 3Improving quality and access to advanced cancer care in India and South Asia 4Improving quality and access to advanced cancer care in India and South Asia 5ResMed To Announce Fourth Quarter And Fiscal Year-End 2014 Results 2
... Soligenix, Inc. (OTC Bulletin Board: SNGX ) ... today that it has appointed Kevin Horgan, MD, as ... Horgan is a board-certified gastroenterologist with a research background ... patients with inflammatory bowel disease, including graft-versus-host disease (GVHD). ...
... JOLLA, Calif., Feb. 1, 2011 Transdel Pharmaceuticals, ... a specialty pharmaceutical company focused on developing topically ... announced that the Company has been exploring strategic alternatives ... American MedTech Advisors and ESC Advisors, a division ...
Cached Medicine Technology:Soligenix Appoints Kevin Horgan, MD, as Chief Medical Officer 2Soligenix Appoints Kevin Horgan, MD, as Chief Medical Officer 3Soligenix Appoints Kevin Horgan, MD, as Chief Medical Officer 4Transdel Pharmaceuticals Announces Exploration of Strategic Alternatives 2Transdel Pharmaceuticals Announces Exploration of Strategic Alternatives 3
... 10.1 kg, Interior Dimensions (WxDxH): 31.1 x ... (WxDxH): 44.6 x 22.4 x 20.5 cm, ... 2 - 300 x 35 mm bottles, ... or 1 - 240 x 80 mm ...
... four basic components: sample well plate, filter support ... diagram). The sample well plate is available in ... (see below). All three plates are interchangeable and ... conjunction with a complete system. The tension on ...
... SF (slot format) microfiltration units provide a ... acid in solution onto nitrocellulose or Zeta-Probe ... by using interchangeable templates to form the ... Bio-Dot SF apparatus. Each is available as ...
Dot Blotter - 96-Well Dot Blot...
Medicine Products: