Navigation Links
JCI online early table of contents: Dec. 1, 2010
Date:12/1/2010

articles/view/39828?key=0bb497688c5428a246bd


HEPATOLOGY: The proteins FXR and SHP work together to regulate bile acid levels

Bile acids, which are made in the liver, are involved in numerous biological processes, including digestion of fats, liver regeneration, and energy expenditure. Levels of bile acid are tightly regulated by a feedback loop. Current models place the protein FXR upstream of SHP in a linear pathway within this feedback loop. Now, a team of researchers, led by David Moore, at Baylor College of Medicine, Houston, has shown that in mice FXR and SHP act in parallel within the feedback loop that regulates bile acid levels. Of particular interest was the observation that mice lacking both FXR and SHP showed substantially more severe defects in regulation of bile acid levels than did mice lacking either of the proteins alone. Furthermore, as mice lacking both FXR and SHP developed cholestasis (the accumulation of bile acids in the liver) and liver injury at just 3 weeks of age, the authors suggest that these animals could provide a model for juvenile onset cholestasis, a term that encompasses several genetic diseases including progressive familial intrahepatic cholestasis.

TITLE: Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis

AUTHOR CONTACT:
David D. Moore
Baylor College of Medicine, Houston, Texas, USA.
Phone: 713.798.3313; Fax: 713.798.3017; E-mail: moore@bcm.edu.

View this article at: http://www.jci.org/articles/view/42846?key=061626916eb46a68a308


HEPATOLOGY: Uncovering the in vivo function of the protein Fbxw7 in the liver

Uncovering the in vivo function of the protein Fbxw7 has been difficult because mice lacking Fbxw7 die in utero. However, by selectively deleting Fbxw7 in
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10

Related medicine news :

1. TheReliefPlace.com Launches Online Store “The Relief Shop” - What Does this Medical Supply Store Carry and How Can They Help You?
2. Web Content Management Enables Government Transparency, Participation, and Collaboration Online
3. DavisPTnetwork Partners with the New York Physical Therapy Association to Provide Online Continuing Education
4. PERSONALABS Offers Discounted Healthy Heart Online Blood Tests in February
5. Pharmahelper Pleased To Recognize Online Pharmacy Practice Standards Announced By Google Adwords
6. Online Dating Reinvents Itself with the Recent Roll-Out of Teacherhookup.com, a Free Website that Focuses on a Person's Career in Education!
7. EdenHome.com Adds Aventura Organic Clothes to Site and Announces Largest Online Selection of Stylish Organic Clothes for Men, Women and Children
8. Fire Protection Online Resolves Safety Concerns with CO2 Fire Extinguishers
9. JCI online early table of contents: Feb. 15, 2010
10. Fitness Trend Towards Online Personal Training Gets Real-World Weight Loss Results on FitOrbit.com
11. New Online Store Makes Buying Cosmetics a Healthy Choice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... (PRWEB) August 22, 2014 Millennium Treatment Group ... resulting in a high level of drug use among teenagers. ... fight against drug addiction and work to minimize drug abuse. ... of alcohol and drug addiction in history. According to the ... estimated 23.9 million Americans aged 12 or older—or 9.2 percent ...
(Date:8/22/2014)... The regional economy is about to get a ... grow again. The plant will invest $100 million ... production of the popular Highlander midsize sport utility vehicle. ... $4 billion. This step allows Toyota to utilize existing ... adjust its product mix to meet changing customer demand. ...
(Date:8/22/2014)... A Penn Medicine team has found that targeted ... urinary tract infections in hospital patients with urinary ... alert was simplified, the rate of improvement dramatically ... their patients need urinary catheters in the first ... need for catheters that have not been removed ...
(Date:8/22/2014)... Aug. 22, 2014 (HealthDay News) -- Many Americans know little ... the possibility of an outbreak in the United States, a ... they are worried that there will be a major Ebola ... they or an immediate family member will get sick with ... latest Harvard School of Public Health poll. However, those ...
(Date:8/22/2014)... Millennium Treatment Group, a drug ... recently launched a new website. Patients, parents, loved ... now find Millennium Treatment Group at http://www.millenniumtreatmentgroup.com ... at the beginning of July. Everything anyone would ... found on the website. There’s an About Us ...
Breaking Medicine News(10 mins):Health News:Millennium Treatment Group Sees Increase in Marijuana Use Among Youth 2Health News:Toyota Indiana Adding 300 Jobs to Build More Highlanders 2Health News:Penn study: Electronic alerts significantly reduce catheter-associated urinary tract infections 2Health News:Penn study: Electronic alerts significantly reduce catheter-associated urinary tract infections 3Health News:Many Americans Harbor Unfounded Fears About Ebola Outbreak: Survey 2Health News:Millennium Treatment Group Has a New Website 2
... no hard and fast rule as to how a mother should ... than glad to endorse that view as standard positions like sitting ... to override. , Take the case of Nicola Adolphe. ... daughter Deborah was born. ,As manager of a play ...
... had enough. Most Doctors are on the brink of burn ... survey conducted by the Australian Medical Association has found that ... staff shortage, outdated equipments and under trained colleagues from abroad. ... have closed down due to the shortage of doctors. The ...
... a checklist for doctors and nurse to avoid common errors ... hands by the health workers help spread disease to ... to improve patient safety around the world and lessen the ... safety is a primary concern in both developed and developing ...
... clearly raise the risk of the allergic sensitisation of children ... , however, the influence of the environment at home on ... the conclusion reached by scientists from the GSF National ... ,The study published by Chih-Mei Chen et al. in ...
... calcium and vitamin D are significantly more likely to have ... can increase risk of cognitive impairment, dementia, depression and stroke. ... and the University of North Carolina examined magnetic resonance imaging ... women) between the ages of 60 and 86 (average age ...
... of maternity units in UK is an eye-opener to prevailing ... the hospitals. In a sting operation conducted by BBC, some ... practices. ,Some of the maternity units were facing ... were overburdened with work. The midwife in charge at a ...
Cached Medicine News:Health News:New Research Promises To Take The Pain Off Breast Feeding 2Health News:New Research Promises To Take The Pain Off Breast Feeding 3Health News:UN Agencys Checklist on Health Care Error 2Health News:Cats at Home Poses Allergy Risk in Young Children 2Health News:Higher Intake of Calcium and Vitamin D Linked With Brain Lesions in Older People 2Health News:United Kingdom: Maternity Units Exposed! Leaves Much to Be Desired 2
(Date:8/21/2014)... HOUSTON , Aug. 21, 2014   Memorial Hermann ... Anderson Cancer Center today announced a new partnership to ... network of community breast care centers in the greater ... November, MD Anderson will become the exclusive provider of professional ... care centers, located in Memorial City, The Woodlands ...
(Date:8/21/2014)...  Publicis Groupe customer engagement agency Rosetta ... Healthcare Industry Group Leader, has been featured in the ... inspiring people in the life-sciences industry. Those chosen for ... marketing, technology, creativity, strategy and medicine. ... in its leading Rosetta Consulting practice. In 2012, she ...
(Date:8/21/2014)... HAMBURG, Germany , Aug. 21, 2014 /PRNewswire/ ... collaborating with Deutsches Elektronen-Synchrotron ( DESY ), a leading ... to speed up management and storage of massive volumes ... Analytics architecture based on IBM software defined technology ... data at peak performance and help scientists worldwide gain ...
Breaking Medicine Technology:Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 2Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 3Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 4Shannon Hartley Shines in PharmaVOICE 100 2DESY and IBM Develop Big Data Architecture for Science 2DESY and IBM Develop Big Data Architecture for Science 3
... image quality at low light intensity. Leica ... system is specifically designed for imaging applications ... create bright, vibrant images without noise or ... by the Leica cameras allow dark and ...
Coolpix 4500 microscope package includes Coolpix 4500 digital camera, MDC-A relay lens and EH52 AC adapter....
Semi-Automated Chemistry Analyzer with model screen master. The Screen Master incorporates many powerful features in one compact unit. Useful for biochemical investigations, enzymatic, immunoturbidi...
... Geometric Data Hemastainer. Formulated to ... quality control tested on human ... staining and absence of precipitate. ... a minimum of eight hours ...
Medicine Products: