Navigation Links
JCI online early table of contents: Dec. 1, 2010
Date:12/1/2010

articles/view/39828?key=0bb497688c5428a246bd


HEPATOLOGY: The proteins FXR and SHP work together to regulate bile acid levels

Bile acids, which are made in the liver, are involved in numerous biological processes, including digestion of fats, liver regeneration, and energy expenditure. Levels of bile acid are tightly regulated by a feedback loop. Current models place the protein FXR upstream of SHP in a linear pathway within this feedback loop. Now, a team of researchers, led by David Moore, at Baylor College of Medicine, Houston, has shown that in mice FXR and SHP act in parallel within the feedback loop that regulates bile acid levels. Of particular interest was the observation that mice lacking both FXR and SHP showed substantially more severe defects in regulation of bile acid levels than did mice lacking either of the proteins alone. Furthermore, as mice lacking both FXR and SHP developed cholestasis (the accumulation of bile acids in the liver) and liver injury at just 3 weeks of age, the authors suggest that these animals could provide a model for juvenile onset cholestasis, a term that encompasses several genetic diseases including progressive familial intrahepatic cholestasis.

TITLE: Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis

AUTHOR CONTACT:
David D. Moore
Baylor College of Medicine, Houston, Texas, USA.
Phone: 713.798.3313; Fax: 713.798.3017; E-mail: moore@bcm.edu.

View this article at: http://www.jci.org/articles/view/42846?key=061626916eb46a68a308


HEPATOLOGY: Uncovering the in vivo function of the protein Fbxw7 in the liver

Uncovering the in vivo function of the protein Fbxw7 has been difficult because mice lacking Fbxw7 die in utero. However, by selectively deleting Fbxw7 in
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10

Related medicine news :

1. TheReliefPlace.com Launches Online Store “The Relief Shop” - What Does this Medical Supply Store Carry and How Can They Help You?
2. Web Content Management Enables Government Transparency, Participation, and Collaboration Online
3. DavisPTnetwork Partners with the New York Physical Therapy Association to Provide Online Continuing Education
4. PERSONALABS Offers Discounted Healthy Heart Online Blood Tests in February
5. Pharmahelper Pleased To Recognize Online Pharmacy Practice Standards Announced By Google Adwords
6. Online Dating Reinvents Itself with the Recent Roll-Out of Teacherhookup.com, a Free Website that Focuses on a Person's Career in Education!
7. EdenHome.com Adds Aventura Organic Clothes to Site and Announces Largest Online Selection of Stylish Organic Clothes for Men, Women and Children
8. Fire Protection Online Resolves Safety Concerns with CO2 Fire Extinguishers
9. JCI online early table of contents: Feb. 15, 2010
10. Fitness Trend Towards Online Personal Training Gets Real-World Weight Loss Results on FitOrbit.com
11. New Online Store Makes Buying Cosmetics a Healthy Choice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2015)... Malibu Biotech Systems LLC salutes ... KissSafe™ is the first personal hygiene product dedicated ... adding fresh breath appeal. KissSafe™ contains an FDA-approved ... in the mouth and oral cavity before and ... possess additional wellness benefits. KissSafe’s proprietary prevent-tech will ...
(Date:5/4/2015)... In a continuing effort to remain a leading ... the founder of Choices Recovery in South Bend, IN, ... the Oscars” celebration held on February 21st, 2015, ... the luxurious Beverly Hilton Hotel. , Organized by ... placement in TV and film, this daylong event gathered ...
(Date:5/4/2015)... 04, 2015 Takeda Pharmaceuticals Corp. has ... settle thousands of Actos lawsuits ( http://www.theactoslawsuitcenter.com/ ) ... risk that a patient will develop bladder cancer. According ... 95% of those eligible for the Actos settlement accept ... cancer cases currently pending in courts around the country, ...
(Date:5/4/2015)... California (PRWEB) May 04, 2015 Getting ... to manage their health is critical to achieving the ... and reducing costs, but this will require a shift ... change also demands that health systems move beyond their ... who took part in the third live meeting of ...
(Date:5/4/2015)... TROY Healthcare Solutions is proud to be a ... (RUG) Conference in Baltimore, MD from May 11 – ... provides an opportunity for clients to gather to network, ... In addition to sponsoring the event, TROY Healthcare Solutions ... Conference. Attendees can stop by the TROY booth and ...
Breaking Medicine News(10 mins):Health News:80 Million Germs from Kissing - Introducing KissSafe™ 2Health News:Per Wickstrom Interviews TV and Film Star Carolyn Hennesy About Substance Abuse and Treatment 2Health News:Actos Lawsuit Settlement: Takeda Pharmaceutical Co. to Pay As Much As $2.4 Billion to Resolve Claims Alleging Actos Causes Bladder Cancer 2Health News:Actos Lawsuit Settlement: Takeda Pharmaceutical Co. to Pay As Much As $2.4 Billion to Resolve Claims Alleging Actos Causes Bladder Cancer 3Health News:AJMC’s ACO Coalition Explores the New Rules of Patient Engagement 2Health News:AJMC’s ACO Coalition Explores the New Rules of Patient Engagement 3Health News:AJMC’s ACO Coalition Explores the New Rules of Patient Engagement 4Health News:TROY Healthcare to Exhibit at the Cerner North Atlantic Regional User Group Conference 2Health News:TROY Healthcare to Exhibit at the Cerner North Atlantic Regional User Group Conference 3
... , TAMPA, Fla., Nov. 4 ... today its SNP Model of Care program to assist Special ... Medicare Improvements for Patients and Providers Act of 2008 (MIPPA). ... with Health Integrated will install a cost-effective, rapidly deployable program ...
... New ... orthopedic and sport uses. , ... San Diego, CA (PRWEB) November 4, 2009 -- BetterBraces.com, the sports bracing ... The new site continues BetterBraces.com commitment to provide customers with top quality braces and ...
... successes, especially for those with good lung function , ... 100 percent for people with early-stage lung cancer and ... radiosurgery using CyberKnife, according to a new study funded ... people with small lung tumors calls for surgical removal ...
... NEW YORK, Nov. 4 Vitech Systems Group, ... benefits administration, announced today that the Milwaukee County ... Vitech,s web-based customer self-service solution. This new self-service ... retired employees of Milwaukee County to receive real-time ...
... study accepted for publication in The Endocrine Society,s Journal ... quickly, as compared to slowly, curtails the release of hormones ... The decreased release of these hormones, can often lead to ... can lead to food overconsumption and obesity, and in fact ...
... ... On Mandatory Sleep Apnea Testing And "Successful Treatment", It Is Practically ... More Than 60% Of Sleep Apnea Patients Can Not Tolerate The ... Commercial Pilots And Drivers May Forever Lose Their Pilot,s Or Driver,s ...
Cached Medicine News:Health News:Health Integrated Announces Turnkey Model of Care Program for Special Needs Health Plans 2Health News:Health Integrated Announces Turnkey Model of Care Program for Special Needs Health Plans 3Health News:The Sports Bracing and Therapy Experts Re-Launch Website BetterBraces.com 2Health News:Focused Radiation May Help Some With Lung Cancer 2Health News:Milwaukee County Employees' Retirement System (MCERS) Goes Live with V3 Self-Service 2Health News:New scientific study indicates that eating quickly is associated with overeating 2Health News:SleepApneaUSA.net Announced An Alternative Sleep Apnea Solution For Commercial Pilots After NTSB Recommended Mandatory Sleep Apnea Certification For Testing And 'Successful Treatment' 2Health News:SleepApneaUSA.net Announced An Alternative Sleep Apnea Solution For Commercial Pilots After NTSB Recommended Mandatory Sleep Apnea Certification For Testing And 'Successful Treatment' 3Health News:SleepApneaUSA.net Announced An Alternative Sleep Apnea Solution For Commercial Pilots After NTSB Recommended Mandatory Sleep Apnea Certification For Testing And 'Successful Treatment' 4Health News:SleepApneaUSA.net Announced An Alternative Sleep Apnea Solution For Commercial Pilots After NTSB Recommended Mandatory Sleep Apnea Certification For Testing And 'Successful Treatment' 5
(Date:5/4/2015)... 2015 Transportation Insight, a leading global ... client, DSI Systems Inc., are featured in the ... in the cover story emphasizing technology as the ... editorial illustrates how Transportation Insight implemented its ... growth and success of DSI,s complex supply chain. ...
(Date:5/4/2015)... , May 4, 2015 DePuy Synthes CMF* ... Repair, the first commercially available biosynthesized dural replacement derived ... is a part of the DePuy Synthes Companies of ... tissue membrane that covers and protects the brain and ... to allow surgeons to access the brain. A dural ...
(Date:5/4/2015)... -- The board of directors of Eli Lilly and Company (NYSE: ... quarter of 2015 of $0.50 per share on outstanding common ... 2015, to shareholders of record at the close of business ... Lilly is a global healthcare leader that unites caring with ... We were founded more than a century ago by a ...
Breaking Medicine Technology:Transportation Insight's Latest Enterprise Logistics Technology Highlighted in Inbound Logistics Magazine 2Transportation Insight's Latest Enterprise Logistics Technology Highlighted in Inbound Logistics Magazine 3DePuy Synthes CMF Launches First Biosynthesized Cellulose-Based Dural Replacement For Neurosurgery 2DePuy Synthes CMF Launches First Biosynthesized Cellulose-Based Dural Replacement For Neurosurgery 3
... BOZEN, Sud-Tirol, Italy , July 20, 2010 ... rights in Spain and Portugal to world-leading IV,Therapy company ... at Vall d,Hebron University Hospital in Barcelona in November,2010 . ... "We are ...
... , WILMINGTON, Del. , July 20 ... Be Heard… Living With Depression contest, ... Bipolar Support Alliance (DBSA), encourages people with depressive symptoms of ... depression) to share their stories of success.  Submissions are now ...
Cached Medicine Technology:Health Robotics' CytoCare Continues European Expansion With Grifols and Vall d'Hebron University Hospital 2Health Robotics' CytoCare Continues European Expansion With Grifols and Vall d'Hebron University Hospital 3Health Robotics' CytoCare Continues European Expansion With Grifols and Vall d'Hebron University Hospital 4National Contest Encourages People with Depressive Symptoms of Bipolar Disorder or Major Depressive Disorder to Speak Out 2National Contest Encourages People with Depressive Symptoms of Bipolar Disorder or Major Depressive Disorder to Speak Out 3National Contest Encourages People with Depressive Symptoms of Bipolar Disorder or Major Depressive Disorder to Speak Out 4National Contest Encourages People with Depressive Symptoms of Bipolar Disorder or Major Depressive Disorder to Speak Out 5National Contest Encourages People with Depressive Symptoms of Bipolar Disorder or Major Depressive Disorder to Speak Out 6National Contest Encourages People with Depressive Symptoms of Bipolar Disorder or Major Depressive Disorder to Speak Out 7
... Supplemental Confirmatory (Western Blot): The Genetic Systems ... test for the detection of antibodies to HIV-1. ... strain of HIV-1 grown in the CEM cell ... is devoid of HLA Class ll antigens, helps ...
... Screening: The Procleix System has added ... the nation's blood supply. It utilizes innovative ... and a unique nucleic acid amplification technique ... can simultaneously detect the presence of HIV-1 ...
... Diagnostic, Non-Donor Screen. Vironostika HIV assays provide ... additional testing and confirmation. Vironostika HIV-1 ... for the detection of antibody to HIV-1 ... Oral Fluid Vironostika HIV-1 Microelisa System ...
... an OraSure HIV-1 Oral Specimen Collection Device is ... for HIV-1 antibodies. Testing with the OraSure HIV-1 ... needles and has been shown to be more ... specially treated cotton fiber pad attached to a ...
Medicine Products: