Navigation Links
JCI online early table of contents: Dec. 1, 2010
Date:12/1/2010

hi
Kobe University Graduate School of Medicine, Kobe, Japan.
Phone: 81.78.382.5861; Fax: 81.78.382.2080; E-mail: takahash@med.kobe-u.ac.jp.

View this article at: http://www.jci.org/articles/view/44073?key=b3118ac5bf4c06518215


ONCOLOGY: From failed DNA repair, to altered energy generation, to tumor cell

Individuals with the genetic disorder xeroderma pigmentosum are extremely sensitive to light from the sun and have an increased risk of developing skin cancer. In a subset of individuals, the condition is caused by mutations in the XPC gene, which generates a protein known to be important in repairing damaged DNA. A team of researchers led by David Bickers, at Columbia University, New York, and Hamid Reza Rezvani, at INSERM U876, France have now provided new insight into how loss of XPC might lead to the formation of skin cancer in patients with xeroderma pigmentosum.

In the study, knocking down levels of XPC in human skin cells (keratinocytes) generated cells capable of causing skin cancer when injected into mice. Analysis of the cells showed that XPC knockdown led to the accumulation of damaged DNA. This, in turn, changed the way in which the keratinocytes generated energy such that they used the same energy-generating pathways used by cancer cells. This led to increased production of damaging molecules known as ROS, the gradual accumulation of mutations in mitochondrial DNA, and the formation of a tumor cell. These data delineate a new pathway by which mutations in a DNA repair gene can lead to tumor formation via effects on cellular energy generation.

TITLE: XPC silencing in normal human keratinocytes triggers metabolic alterations that drive the formation of squamous cell carcinomas

AUTHOR CONTACT:
David R. Bickers
College of Physicians and Surgeons
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10

Related medicine news :

1. TheReliefPlace.com Launches Online Store “The Relief Shop” - What Does this Medical Supply Store Carry and How Can They Help You?
2. Web Content Management Enables Government Transparency, Participation, and Collaboration Online
3. DavisPTnetwork Partners with the New York Physical Therapy Association to Provide Online Continuing Education
4. PERSONALABS Offers Discounted Healthy Heart Online Blood Tests in February
5. Pharmahelper Pleased To Recognize Online Pharmacy Practice Standards Announced By Google Adwords
6. Online Dating Reinvents Itself with the Recent Roll-Out of Teacherhookup.com, a Free Website that Focuses on a Person's Career in Education!
7. EdenHome.com Adds Aventura Organic Clothes to Site and Announces Largest Online Selection of Stylish Organic Clothes for Men, Women and Children
8. Fire Protection Online Resolves Safety Concerns with CO2 Fire Extinguishers
9. JCI online early table of contents: Feb. 15, 2010
10. Fitness Trend Towards Online Personal Training Gets Real-World Weight Loss Results on FitOrbit.com
11. New Online Store Makes Buying Cosmetics a Healthy Choice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... 2014 “Today, we have said ¡Basta! ... are being promoted to our children and our families. ... the beverage industry to put the health of people ... Jane L. Delgado, President and CEO of the National ... Sugar-Sweetened Beverage Tax (SWEET) Act by Congresswoman Rosa L. ...
(Date:7/30/2014)... San Ramon, CA (PRWEB) July 30, 2014 ... in the ancient redwood forests of the Pomo Indians ... California. The Pomo called the river Shabaikai, meaning ‘crooked ... with its labor strife and the violence of prohibition ... Bohemian Club at Russian River. Here, the most powerful ...
(Date:7/30/2014)... July 30, 2014 The North America ... million by 2019. North America is expected to be ... market at a CAGR of 5.60%. , The ... and challenges which will assume prominence in the years ... past, yet the sector has regained quickly, and the ...
(Date:7/30/2014)... 2014 “North America Contrast Media Injectors ... the North America Contrast Media Injectors market. The report ... (in units) and average price data (in US dollars), ...     Interventional Cardiology/Angio Injectors and MRI Injectors ... a substance used to enhance the contrast of structures ...
(Date:7/30/2014)... (PRWEB) July 30, 2014 With the recent ... Ground Zero, the Ground Zero Museum Workshop in the Meatpacking ... bookings. Says the Museum Workshop's Carole Barnes, "We have had ... all the major travel sites who sell us so tourists ... crystal clear as to what we do and what the ...
Breaking Medicine News(10 mins):Health News:National Alliance for Hispanic Health Statement on Introduction of SWEET Act 2Health News:Bill E. Clarkson Releases Debut Fact-Based Novel, Shabaikai 2Health News:North America Aviation Actuation System Market is Expected to Reach $1781.02 million in 2019 - New Report by MicroMarket Monitor 2Health News:North America Aviation Actuation System Market is Expected to Reach $1781.02 million in 2019 - New Report by MicroMarket Monitor 3Health News:North America Aviation Actuation System Market is Expected to Reach $1781.02 million in 2019 - New Report by MicroMarket Monitor 4Health News:Contrast Media Injectors Market in North America (US, Canada, Mexico) to 2020 Report Available at MarketOptimizer.org 2Health News:Contrast Media Injectors Market in North America (US, Canada, Mexico) to 2020 Report Available at MarketOptimizer.org 3Health News:Contrast Media Injectors Market in North America (US, Canada, Mexico) to 2020 Report Available at MarketOptimizer.org 4Health News:Despite Some Confusion over 9/11 Memorial Opening, Kid-Friendly Ground Zero Museum Workshop on 14th Street Continues It's Mission 2Health News:Despite Some Confusion over 9/11 Memorial Opening, Kid-Friendly Ground Zero Museum Workshop on 14th Street Continues It's Mission 3Health News:Despite Some Confusion over 9/11 Memorial Opening, Kid-Friendly Ground Zero Museum Workshop on 14th Street Continues It's Mission 4Health News:Despite Some Confusion over 9/11 Memorial Opening, Kid-Friendly Ground Zero Museum Workshop on 14th Street Continues It's Mission 5
... The Health Resources,and Services Administration (HRSA) at ... today proposed a new rule that will improve ... target federal,resources to the people and communities who ... today,s Federal Register, consolidates the,criteria for designating medically ...
... no apparent side effects, O. formigenes reduced ... A naturally occurring type of bacteria called Oxalobacter formigenes ... 70 percent, a new study says. , The study ... stones and compared them to a control group of 259 ...
... Children with special,health care needs have higher ... have regular sources of health care when they ... and Services Administration (HRSA),indicates., The latest edition ... Care Needs Chartbook 2005-2006 ( http://mchb.hrsa.gov/cshcn05/ ),reports that ...
... 5 Anthem National Accounts today,announced the addition ... needs of early retirees -- a growing segment ... is designed to meet the needs of,pre-65 retirees ... affordable,access to medical coverage while helping to reduce ...
... Session Leverages Personal Health Care Utilization and Employee Data ... , WHO: Daryl Ashley, senior vice president and ... Outsourced Benefits Administration for Workscape, a leading ... Will be a featured presenter in the "Getting Personal -- ...
... and anchor ... depth, ... SN) Endoscopy Division today announced the launch of the,BIORAPTOR 2.3 PK Suture ... is featured at Smith & Nephew Endoscopy,s booth,at the American Academy of ...
Cached Medicine News:Health News:HRSA Proposes Rule to Revise, Combine HPSAs, MUPs 2Health News:Naturally Occurring Bacteria Cut Kidney Stone Recurrence 2Health News:High Numbers of Children With Special Needs Have Health Insurance, Regular Caregivers, HRSA Survey Finds 2Health News:Anthem National Accounts Introduces New Products for Large Employers' Early Retirees 2Health News:Anthem National Accounts Introduces New Products for Large Employers' Early Retirees 3Health News:Upcoming Business Health Agenda 2008 Features Workscape Executive 2Health News:Smith & Nephew Endoscopy's BIORAPTOR(TM) 2.3 PK Suture Anchor Provides Secure Repair for Shoulder, Hip Instability 2Health News:Smith & Nephew Endoscopy's BIORAPTOR(TM) 2.3 PK Suture Anchor Provides Secure Repair for Shoulder, Hip Instability 3Health News:Smith & Nephew Endoscopy's BIORAPTOR(TM) 2.3 PK Suture Anchor Provides Secure Repair for Shoulder, Hip Instability 4
(Date:7/30/2014)... , July 30, 2014  El Camino Hospital, ... patient care, is utilizing the Leaf Patient Monitoring system ... position and movement of patients susceptible to bed sores. ... six month-long, 138-patient study of the system, which showed ... protocols. Turning patients regularly is the one of the ...
(Date:7/30/2014)... 30, 2014 Research and Markets ... Chinese Aseptic Packaging Industry Report 2014" report to ... The Global and Chinese Aseptic Packaging Industry ... current state of the global Aseptic Packaging industry with ... provides a basic overview of the industry including definitions, ...
(Date:7/30/2014)... , July 30, 2014 Reportlinker.com ... available in its catalogue: mHealth and ... http://www.reportlinker.com/p0356852/mHealth-and-Home-Monitoring-–-6th-Edition.html Executive summary ... delivered, leading to better outcomes, decreased costs and ... for mHealth solutions is still in an early ...
Breaking Medicine Technology:El Camino Hospital Utilizes Cutting-Edge Leaf Patient Monitor System to Help Reduce Risk of Pressure Ulcers 2El Camino Hospital Utilizes Cutting-Edge Leaf Patient Monitor System to Help Reduce Risk of Pressure Ulcers 3Global and Chinese Aseptic Packaging Industry Report 2014 2mHealth and Home Monitoring - 6th Edition 2mHealth and Home Monitoring - 6th Edition 3mHealth and Home Monitoring - 6th Edition 4mHealth and Home Monitoring - 6th Edition 5mHealth and Home Monitoring - 6th Edition 6mHealth and Home Monitoring - 6th Edition 7mHealth and Home Monitoring - 6th Edition 8mHealth and Home Monitoring - 6th Edition 9mHealth and Home Monitoring - 6th Edition 10mHealth and Home Monitoring - 6th Edition 11
... May 5, 2011 Ridge Diagnostics, Inc., a ... at the 6th Annual Neurotech Investing and Partnering Conference to ... Hotel on May 9th and 10th.   Ms. ... panel entitled "Next Generation Psychiatry" lead by Dr. Manuel Lopez-Figueroa, ...
... INDIANAPOLIS, May 5, 2011 Eli Lilly and Company ... an Indianapolis-based nonprofit that supports bold, new education reform, ... What Works campaign. Grow What Works seeks to raise ... working in Indianapolis, enabling them to serve more students ...
Cached Medicine Technology:Ridge Diagnostics, Inc. CEO to Speak at Neurotech Investing and Partnering Conference 2Eli Lilly and Company Invests $2.5 Million to Launch The Mind Trust's Grow What Works Campaign 2Eli Lilly and Company Invests $2.5 Million to Launch The Mind Trust's Grow What Works Campaign 3Eli Lilly and Company Invests $2.5 Million to Launch The Mind Trust's Grow What Works Campaign 4
... incorporate a layered design unique in the ... to prevent stray electrosurgical burns along the ... failure or capacitive coupling; a well-documented patient ... all AEM Instruments provides a neutral return ...
... The 5mm AEM Laparoscopic Instruments incorporate a ... Instruments are shielded and monitored to prevent ... the instrument caused by insulation failure or ... The protective shield built into all AEM ...
... Instruments incorporate a layered design unique in ... monitored to prevent stray electrosurgical burns along ... insulation failure or capacitive coupling; a well-documented ... into all AEM Instruments provides a neutral ...
The Auto Suture™ ExtraHand™ balloon retractor is designed to be used during open surgery, gasless endoscopy, as well as endoscopy with gas insufflation....
Medicine Products: