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JCI online early table of contents: Dec. 1, 2010
Date:12/1/2010

e mice, leading the authors to look at this in human Wilms tumor. As increased ERK1/2 activity was also observed in some human Wilms tumors, the authors suggest that their new mouse model of Wilms tumor will provide a useful tool to study the initiation and progression of Wilms tumor and to investigate potential new therapeutic strategies.

TITLE: Wt1 ablation and Igf2 upregulation in mice result in Wilms tumors with elevated ERK1/2 phosphorylation

AUTHOR CONTACT:
Vicki Huff
University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
Phone: 713.834.6384; Fax: 713.834.6380; E-mail: vhuff@mdacc.tmc.edu.

View this article at: http://www.jci.org/articles/view/43772?key=327424cb3e5048c4b90e

ENDOCRINOLOGY: Hormone deficiency is the pits

The pituitary is a gland at the base of the brain that produces a number of hormones that regulate growth, reproduction, and metabolism. PIT-1 is a gene that controls the expression of many of those hormones, including growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH). Human mutations in PIT-1 are linked to short stature and multiple hormone deficiency. In new research, Yukaka Takahashi and colleagues at Kobe University Graduate School of Medicine in Kobe, Japan, investigated several patients who exhibited normal growth but adult-onset deficiency of GH, PRL, and TSH. They found that although these patients did not have mutations in PIT-1, each had PIT-1specific antibodies in their blood. The researchers believe that these patients suffer from a unique autoimmune disorder that results in the immune system attacking PIT-1expressing cells in the pituitary.

TITLE: Adult combined GH, prolactin, and TSH deficiency associated with circulating PIT-1 antibody in humans

AUTHOR CONTACT:
Yutaka Takahas
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Contact: Karen Honey
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Journal of Clinical Investigation
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