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JCI online early table of contents: Dec. 1, 2010
Date:12/1/2010

Prdm16, a gene known to promote BAT development, was expressed in sub-cutaneous but not visceral WAT. Mice engineered to over-express Prdm16 in fat tissue had increased brown-like cell accumulation, and had reduced weight gain when placed on a high fat-diet. The researchers believe that these results show that Prdm16 is a critical factor for brown-like cell development, and that controlling its expression in subcutaneous WAT may be a promising therapeutic strategy in fighting obesity and diabetes.

TITLE: Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

AUTHOR CONTACT:
Patrick Seale
University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Phone: 215.573.8856 Fax: 215.898.5408; E-mail: sealep@upenn.edu.

Bruce M. Spiegelman
Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Phone: 617.632.3567; Fax: 617.632.5363; E-mail: bruce_spiegelman@dfci.harvard.edu.

View this article at: http://www.jci.org/articles/view/44271?key=b4f7a6be736af84cb237


ONCOLOGY: New insights into Wilms tumor

Wilms tumor is a childhood kidney tumor. Many different genetic alterations have been identified in Wilms tumors, with some tumors having one detectable genetic alteration and others having multiple. How individual or combinations of genetic alterations cause tumors to arise has been difficult to determine because there is no mouse model of the condition. However, Vicki Huff and colleagues, at the University of Texas M.D. Anderson Cancer Center, Houston, have now generated a mouse model of the subset of Wilms tumors in which the WT1 gene is inactivated and the IGF2 gene is expressed at higher than normal levels. Increased activity of the signaling molecules ERK1/2 was observed in thes
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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