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JCI online early table of contents: Dec. 1, 2010
Date:12/1/2010

led by Xiaojiang Cui, at the John Wayne Cancer Institute, Santa Monica; Ning-Hui Cheng, Baylor College of Medicine, Houston; and Ning Zhang, at Tianjin Medical University, China have now determined that the protein TXNL2 helps protect human breast cancer cells from high levels of ROS. Of interest, knocking down TXNL2 levels in human breast cancer cells inhibited their ability to form tumors upon transplantation into mice. Furthermore, enhanced TXNL2 expression in primary breast cancer samples correlated with cancer spread to the lung and brain and with decreased survival. The authors therefore suggest that TXNL2 could be a new therapeutic target for the treatment of breast cancer.

TITLE: Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-kB signaling

AUTHOR CONTACT:
Xiaojiang Cui
John Wayne Cancer Institute, Santa Monica, California, USA.
Phone: 310.998.3916; Fax: 310.582.7390; E-mail: cuix@jwci.org.

Ning-Hui Cheng
Baylor College of Medicine, Houston, Texas, USA.
Phone: 713.798.9326; Fax: 713.798.7101; E-mail: ncheng@bcm.tmc.edu.

Ning Zhang
Tianjin Medical University, Tianjin, China.
Phone: 86.13502179648; Fax: 86.22.23542068; E-mail: nzhangchina@yahoo.com.

View this article at: http://www.jci.org/articles/view/43144?key=b9f6d6b93a68a2798fdc


NEPHROLOGY: Genetic mutations underlying rare human kidney disorder identified

Dicarboxylic aminoaciduria is a rare inherited disorder for which the affected gene has not yet been identified. Individuals with this disorder excrete extremely high levels of the protein building blocks glutamate and aspartate in their urine, due to inefficient handling of these molecules by
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Journal of Clinical Investigation
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