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JCI online early table of contents: Dec. 1, 2010
Date:12/1/2010

mouse liver cells, a team of researchers, led by Keiichi Nakayama, at Kyushu University, Japan, has now determined that Fbxw7 has key roles in the liver, where it regulates the formation of lipids (fats) and the proliferation and differentiation of liver cells.

The team used two approaches to delete the gene responsible for generating Fbxw7 specifically in mouse liver cells. The resulting mice had massively enlarged livers and developed steatohepatitis (inflammation of the liver accompanied by fat accumulation in the same organ). Additional analysis indicated that the enlarged liver was associated with markedly increased cell proliferation and that Fbxw7-deficient liver stem cells were skewed to become bile duct cells rather than liver cells. The authors therefore conclude that Fbxw7 contributes to distinct biological functions in a tissue-specific manner.

TITLE: Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver

AUTHOR CONTACT:
Keiichi I. Nakayama
Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Phone: 81.92.642.6815; Fax: 81.92.642.6819; E-mail: nakayak1@bioreg.kyushu-u.ac.jp.

View this article at: http://www.jci.org/articles/view/40725?key=c892c9a83212290cb6f4


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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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