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JCI online early table of contents: August 2, 2010

rotease activity contributes to control of Mycobacterium tuberculosis in hypoxic lung granulomas in mice

Stephen T. Reece
Max Planck Institute for Infection Biology, Berlin, Germany.
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Stefan H.E. Kaufmann
Max Planck Institute for Infection Biology, Berlin, Germany.
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VIROLOGY: The real deal: genetically intact human cytomegalovirus can now be studied

A large proportion of adults (approximately 40% worldwide) are infected with human cytomegalovirus (HCMV), a virus that persists lifelong in the body once it has entered it. It is hard to study HCMV because the viruses present in our bodies cannot replicate efficiently in vitro until they have undergone substantial mutation. However, a team of researchers, led by Richard Stanton, at Cardiff University, United Kingdom, has now generated a genetically intact source of HCMV in a BAC. The genes RL13 and UL131A must be repressed while the virus replicates in vitro, but the team engineered the BAC such that these genes can be easily switched on and off. This technological advance will enable researchers to study a clinically relevant HCMV.

TITLE: Reconstruction of the complete human cytomegalovirus genome in a BAC reveals RL13 to be a potent inhibitor of replication

Richard J. Stanton
Cardiff University, Cardiff, United Kingdom.
Phone: 44.29.20687319; Fax: 44.29.20742161; E-mail:


Contact: Karen Honey
Journal of Clinical Investigation

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