Navigation Links
JCI online early table of contents: August 2, 2010
Date:8/2/2010

land known as chromaffin cells secreted larger amounts of catecholamines, 'fight-or-flight' hormones such as adrenaline and noradrenaline. The authors therefore conclude that TRPM4 limits catecholamine release from chromaffin cells and that disruption of this control, as in mice lacking TRPM4, increases blood pressure.

TITLE: Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice

AUTHOR CONTACT:
Marc Freichel
Universitt des Saarlandes, Homburg, Germany.
Phone: 49.6841.16.26438; Fax: 49.6841.16.26402; E-mail: marc.freichel@uks.eu.

View this article at: http://www.jci.org/articles/view/41348?key=a8192406a2080917cfba


INFECTIOUS DISEASE: New way to control TB?

Tuberculosis is caused by infection with the bacterium M. tuberculosis. The hallmark of infection is the presence of granulomas (small nodular aggregations of inflammatory cells) in the lungs. Some of these cells, known as macrophages, are infected with M. tuberculosis, which they are desperately trying to kill. One mechanism by which macrophages kill M. tuberculosis is to produce nitric oxide. However, for this to be effective it requires high levels of oxygen, and some granulomas are oxygen deficient (hypoxic).

A team of researchers, led by Stephen Reece and Stefan Kaufmann, at the Max Planck Institute for Infection Biology, Germany, has now identified a way in which M. tuberculosis is killed in hypoxic granulomas in mice. Specifically, they found that hypoxic granulomas contained large amounts of proteins known as serine proteases, which function to degrade other proteins, and that inhibiting these proteases increased bacterial growth. The authors suggest that boosting serine protease activity could represent an attractive approach to treat tuberculosis.

TITLE: Serine p
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6

Related medicine news :

1. New online community launched to help medical practices learn about meaningful use
2. JCI online early table of contents: July 12, 2010
3. Online coverage of XVIII International AIDS Conference to include daily webcasts, live coverage, podcasts and news recaps
4. Sam's Club Tests Online Small Business Loan Program for Main Street
5. SNM cautions that Canadas Chalk River coming back online will not solve long-term isotope shortage
6. Suite 101.com Provides Insight Into Consumer Reading Behavior Online
7. Grand Opening of GreenProductsandGifts.com Online Store Offering Eco Friendly Gifts that are Proudly Made in the USA
8. Vibration Exercise Equipment Available at Fitness4HomeOnline.com
9. Onlineshoes.com and New Balance Pair Up for Toning Shoes Giveaway
10. Online Deals on Golf, now in Full Swing at GolfAdventures.com
11. BVibrantNow, A New All-Natural Health Supplement Business, Launches Free Online Wellness Calendar to Promote Healthy Habits
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2015)... The National Association of Professional ... a 2015-2016 inductee into its VIP Professional Woman of ... distinction for leadership in real estate. NAPW is the ... more than 700,000 members and over 200 operating local ... this exceptional group of professional women," said NAPW President ...
(Date:5/25/2015)... May 26, 2015 The National ... as a 2015-2016 inductee into its VIP Professional Woman ... prestigious distinction for leadership in dentistry. NAPW is the ... more than 700,000 members and over 200 operating local ... this exceptional group of professional women,” said NAPW President ...
(Date:5/25/2015)... Garden City, NY (PRWEB) May 26, 2015 ... Women (NAPW) honors Dr. Heather Stanley-Christian ... Woman of the Year Circle. She is recognized ... NAPW is the nation's leading networking organization exclusively ... and over 200 operating local chapters. , "I'm ...
(Date:5/25/2015)... NY (PRWEB) May 26, 2015 ... Lisa Ferrara, Ph.D., as a 2015-2016 inductee ... is recognized with this prestigious distinction for leadership in ... exclusively for professional women, boasting more than 700,000 members ... to welcome Lisa into this exceptional group of professional ...
(Date:5/25/2015)... World Patent Marketing, a vertically integrated ... a home patent that aims to protect both people ... fires cost the United States a total of $11.7 ... Director of World Patent Marketing . "More than ... have no alarmed protection. With the use of fire ...
Breaking Medicine News(10 mins):Health News:National Association of Professional Women Inducts Anne King, Operating Principal at Keller Williams, Into its VIP Professional Woman of the Year Circle 2Health News:National Association of Professional Women Inducts Dr. Laquinas Hooked, D.D.S. of General Dentist, Into its VIP Professional Woman of the Year Circle 2Health News:NAPW Inducts Dr. Heather Stanley-Christian, Systems Chair/Maternal Fetal Medicine at Stroger Hospital, into Its VIP Professional Woman of the Year Circle 2Health News:National Association of Professional Women Inducts Lisa Ferrara, Ph.D., CEO of OrthoKinetic Technologies, Into its VIP Professional Woman of the Year Circle 2Health News:Home Maintenance Causes House Fires? World Patent Marketing Introduces the Best Home Patent to Prevent Fire Accidents 2Health News:Home Maintenance Causes House Fires? World Patent Marketing Introduces the Best Home Patent to Prevent Fire Accidents 3
... discovered low calorie potatoes, giving spuds, another potato variety, a ... potato, signals the arrival of potatoes that significantly taste better ... choices in ubiquitous potatoes!// ,Vivaldi was the result of ... years. Allied laboratory services has tested this new variety ...
... pressure clinical trial is launching a nationwide outreach program ... // This is a follow-up to the Antihypertensive and ... is being launched in collaboration with the National High ... ALLHAT blood pressure study had compared the effectiveness of ...
... food service policy acceptance in schools it has been ... foodservice directors' perceptions. // ,They have different ... communication among key stakeholders addressing new wellness policy development ... of 2004. ,'Competitive foods are those ...
... Won Jang of the Department of Internal Medicine at the ... that administering an antiviral drug would help prevent hepatitis ... treatment of cancer. ,In hepatocellular carcinoma (HCC), patients ... a result of chemotherapy. Hepatocellular carcinoma or liver cancer is ...
... US based researchers are reported to identified two drugs meant ... contracting the AIDS virus. // As to whether the same ... been confirmed, even though it may be possible. ... Disease and Prevention’s Dr. Walid Heneine, through injecting them with ...
... self- inflicted damage from unclean blades and dirty instruments, it ... addition, they can be provided guidance // on where to ... the provision of sterile needles to drug addicts. ... nurses who attend to mentally ill patients and would be ...
Cached Medicine News:Health News:Diuretics More Effective In Controlling High Blood Pressure 2Health News:Clash of Difference of perceptions in food policy among Principals’ and Director 2Health News:Hepatitis B Relapse In Cancer Chemotherapy Can Be Avoided By Antiviral Drug 2Health News:Clean Blades To Be Provided To Self-Harmers 2
(Date:5/22/2015)... , May 22, 2015  Research and Benchmarking ... sixth Medical Affairs Roundtable on Thursday, ... a virtual roundtable to discuss "Medical Affairs, Role ... Best Practices, Medical Affairs Consortium provides Medical Affairs ... the key challenges they face. The consortium has ...
(Date:5/22/2015)... - The Taskforce representing Canada,s living ... work that the Minister and Health Canada have put into ... the needs of the thalidomide survivors, and more than 70% ... free, with annual adjustments for inflation. Certain of ... $100,000 based on the severity of their disability, tax free, ...
(Date:5/22/2015)... 22, 2015  Amgen (NASDAQ: AMGN ... termination of its participation in the co-development ... STO:AZN and NYSE: AZN ).  Brodalumab, ... for patients with moderate-to-severe plaque psoriasis, psoriatic ... based on events of suicidal ideation and ...
Breaking Medicine Technology:Best Practices Sixth Medical Affairs Consortium Roundtable to Focus on Health Economics & Outcomes Research 2Amgen to terminate participation in co-development and commercialization of brodalumab 2Amgen to terminate participation in co-development and commercialization of brodalumab 3Amgen to terminate participation in co-development and commercialization of brodalumab 4Amgen to terminate participation in co-development and commercialization of brodalumab 5
... Reportlinker.com announces that a new market research report ... Cancer - Global Drug Forecasts and Treatment Analysis to ... http://www.reportlinker.com/p0479812/Bladder-Cancer---Global-Drug-Forecasts-and-Treatment-Analysis-to-2020---Volume-1-2011.html Bladder Cancer - Global Drug ... 2011 Summary GlobalData, ...
... 12, 2011 Qualcomm Incorporated (NASDAQ: QCOM ... Province, Korea Centers for Disease Control and Prevention (KCDC), ... a Memorandum of Understanding for a project that will ... Self Quality Care , which will utilize 3G-enabled ...
Cached Medicine Technology:Reportlinker Adds Bladder Cancer - Global Drug Forecasts and Treatment Analysis to 2020 - Volume 1 2011 2Reportlinker Adds Bladder Cancer - Global Drug Forecasts and Treatment Analysis to 2020 - Volume 1 2011 3Reportlinker Adds Bladder Cancer - Global Drug Forecasts and Treatment Analysis to 2020 - Volume 1 2011 4Reportlinker Adds Bladder Cancer - Global Drug Forecasts and Treatment Analysis to 2020 - Volume 1 2011 5Reportlinker Adds Bladder Cancer - Global Drug Forecasts and Treatment Analysis to 2020 - Volume 1 2011 6Reportlinker Adds Bladder Cancer - Global Drug Forecasts and Treatment Analysis to 2020 - Volume 1 2011 7Reportlinker Adds Bladder Cancer - Global Drug Forecasts and Treatment Analysis to 2020 - Volume 1 2011 8Reportlinker Adds Bladder Cancer - Global Drug Forecasts and Treatment Analysis to 2020 - Volume 1 2011 9Reportlinker Adds Bladder Cancer - Global Drug Forecasts and Treatment Analysis to 2020 - Volume 1 2011 10Reportlinker Adds Bladder Cancer - Global Drug Forecasts and Treatment Analysis to 2020 - Volume 1 2011 11Reportlinker Adds Bladder Cancer - Global Drug Forecasts and Treatment Analysis to 2020 - Volume 1 2011 12Reportlinker Adds Bladder Cancer - Global Drug Forecasts and Treatment Analysis to 2020 - Volume 1 2011 13Reportlinker Adds Bladder Cancer - Global Drug Forecasts and Treatment Analysis to 2020 - Volume 1 2011 14Reportlinker Adds Bladder Cancer - Global Drug Forecasts and Treatment Analysis to 2020 - Volume 1 2011 15Reportlinker Adds Bladder Cancer - Global Drug Forecasts and Treatment Analysis to 2020 - Volume 1 2011 16Reportlinker Adds Bladder Cancer - Global Drug Forecasts and Treatment Analysis to 2020 - Volume 1 2011 17Reportlinker Adds Bladder Cancer - Global Drug Forecasts and Treatment Analysis to 2020 - Volume 1 2011 18Reportlinker Adds Bladder Cancer - Global Drug Forecasts and Treatment Analysis to 2020 - Volume 1 2011 19Reportlinker Adds Bladder Cancer - Global Drug Forecasts and Treatment Analysis to 2020 - Volume 1 2011 20Reportlinker Adds Bladder Cancer - Global Drug Forecasts and Treatment Analysis to 2020 - Volume 1 2011 21Reportlinker Adds Bladder Cancer - Global Drug Forecasts and Treatment Analysis to 2020 - Volume 1 2011 22Reportlinker Adds Bladder Cancer - Global Drug Forecasts and Treatment Analysis to 2020 - Volume 1 2011 23Qualcomm Announces Self Quality Care Project to Benefit Chronic Disease Patients in Korea 2Qualcomm Announces Self Quality Care Project to Benefit Chronic Disease Patients in Korea 3Qualcomm Announces Self Quality Care Project to Benefit Chronic Disease Patients in Korea 4
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: