Navigation Links
JCI online early table of contents: August 2, 2010
Date:8/2/2010

land known as chromaffin cells secreted larger amounts of catecholamines, 'fight-or-flight' hormones such as adrenaline and noradrenaline. The authors therefore conclude that TRPM4 limits catecholamine release from chromaffin cells and that disruption of this control, as in mice lacking TRPM4, increases blood pressure.

TITLE: Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice

AUTHOR CONTACT:
Marc Freichel
Universitt des Saarlandes, Homburg, Germany.
Phone: 49.6841.16.26438; Fax: 49.6841.16.26402; E-mail: marc.freichel@uks.eu.

View this article at: http://www.jci.org/articles/view/41348?key=a8192406a2080917cfba


INFECTIOUS DISEASE: New way to control TB?

Tuberculosis is caused by infection with the bacterium M. tuberculosis. The hallmark of infection is the presence of granulomas (small nodular aggregations of inflammatory cells) in the lungs. Some of these cells, known as macrophages, are infected with M. tuberculosis, which they are desperately trying to kill. One mechanism by which macrophages kill M. tuberculosis is to produce nitric oxide. However, for this to be effective it requires high levels of oxygen, and some granulomas are oxygen deficient (hypoxic).

A team of researchers, led by Stephen Reece and Stefan Kaufmann, at the Max Planck Institute for Infection Biology, Germany, has now identified a way in which M. tuberculosis is killed in hypoxic granulomas in mice. Specifically, they found that hypoxic granulomas contained large amounts of proteins known as serine proteases, which function to degrade other proteins, and that inhibiting these proteases increased bacterial growth. The authors suggest that boosting serine protease activity could represent an attractive approach to treat tuberculosis.

TITLE: Serine p
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6

Related medicine news :

1. New online community launched to help medical practices learn about meaningful use
2. JCI online early table of contents: July 12, 2010
3. Online coverage of XVIII International AIDS Conference to include daily webcasts, live coverage, podcasts and news recaps
4. Sam's Club Tests Online Small Business Loan Program for Main Street
5. SNM cautions that Canadas Chalk River coming back online will not solve long-term isotope shortage
6. Suite 101.com Provides Insight Into Consumer Reading Behavior Online
7. Grand Opening of GreenProductsandGifts.com Online Store Offering Eco Friendly Gifts that are Proudly Made in the USA
8. Vibration Exercise Equipment Available at Fitness4HomeOnline.com
9. Onlineshoes.com and New Balance Pair Up for Toning Shoes Giveaway
10. Online Deals on Golf, now in Full Swing at GolfAdventures.com
11. BVibrantNow, A New All-Natural Health Supplement Business, Launches Free Online Wellness Calendar to Promote Healthy Habits
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2015)... NC (PRWEB) April 26, 2015 Italian ... the deadly legacy of asbestos cement plants and other ... on the new research. Click here to read ... from Italy’s Department of Occupational and Environmental Medicine analyzed ... 2008 and found 32 clusters where the asbestos cancer ...
(Date:4/26/2015)... Indianapolis, Indiana (PRWEB) April 26, 2015 ... network service provider announces that Brotherhood Mutual Insurance Company ... Daniel Armstrong, Manager of Network Infrastructure at Brotherhood Mutual ... value and the service reliability Brotherhood Mutual needed. ... route diversity, and IFN worked with us to ensure ...
(Date:4/26/2015)... NV (PRWEB) April 26, 2015 From ... Trivedi and his wife, Trivedi Master™ Dahryn Trivedi, spent ... FDA approved research laboratories and institutions in the efforts ... drugs, medicine and nutraceutical supplements for human health care. ... 12 different research labs and institutions. All lab facilities ...
(Date:4/26/2015)... (PRWEB) April 26, 2015 India Network ... in delivering valuable community services to the Asian Indian ... projects in India for more than two decades. The ... and thousands of subscribers around the world with the ... at that time. The Immigration Law Forum Digest, edited ...
(Date:4/26/2015)... Santa Rosa, CA (PRWEB) April 26, 2015 ... researchers from Washington State University evaluated the head-neck biomechanics occurring ... Authors of the study were able to determine that use ... as much as 3 to 5 times - more than ... a surprising outcome for such a study, but pointing out ...
Breaking Medicine News(10 mins):Health News:New Investigation Finds Mesothelioma “Clusters” Around Italian Cement Plants, According to Surviving Mesothelioma 2Health News:Brotherhood Mutual Insurance Company Selects Indiana Fiber Network, LLC for Fiber Transport Service 2Health News:Brotherhood Mutual Insurance Company Selects Indiana Fiber Network, LLC for Fiber Transport Service 3Health News:Trivedi Science™ Has Started Scientific Research to Create More Effective Pharmaceuticals and Nutraceuticals 2Health News:Trivedi Science™ Has Started Scientific Research to Create More Effective Pharmaceuticals and Nutraceuticals 3Health News:North American Telugu Society Bestows Community Service Award to India Network Foundation for Its Generosity and Sponsor of Visitor Health Insurance to Indian Visitors 2Health News:North American Telugu Society Bestows Community Service Award to India Network Foundation for Its Generosity and Sponsor of Visitor Health Insurance to Indian Visitors 3Health News:Avoiding the Pain in the Neck Caused by Overuse of Technology 2Health News:Avoiding the Pain in the Neck Caused by Overuse of Technology 3Health News:Avoiding the Pain in the Neck Caused by Overuse of Technology 4
... peers, are key, study finds , , THURSDAY, April 16 ... most important relationships. , But new research shows its ... prevent suicidal behavior in teens who,ve experienced depression or ... high school and a previous suicide attempt were significant ...
... The "Help is Here Express" bus tour will ... - April 24 at various cities in order to help ... prescription medicines for free or nearly free. With the state,s ... of 8.5 percent, the Partnership for Prescription Assistance (PPA) is ...
... the highlights of the annual meeting of the American ... TV quiz shows. , Like a quiz show, Neurobowl ... subtracts points for wrong answers. The tougher the question, ... to diagnose perplexing neurological conditions, based on symptoms, video ...
... To provide greater public access to discussions and deliberations involving ... Americans , the Department of Agriculture today announced that the ... be web-streamed live on April 29th and 30th.A notice regarding ... Federal Register . The Committee will meet on ...
... to expand relationship with healthcare technology solutions providerPLANO, ... and Perot Systems Corporation (NYSE: PER ... an agreement in which Perot Systems will provide ... The multi-year agreement continues TCH,s current relationship where ...
... Nationwide Foundation is making a $1.7 million grant ... affected by disasters and other life-threatening emergencies. This ... contributed this unique grant to the Red Cross.(Logo: ... Nationwide Foundation, an independent corporation funded by Nationwide ...
Cached Medicine News:Health News:Family Ties May Help Prevent Teen Suicide 2Health News:Partnership for Prescription Assistance Prepared to Help Indiana Workers Hurt by Recession 2Health News:Partnership for Prescription Assistance Prepared to Help Indiana Workers Hurt by Recession 3Health News:What do neurologists do for entertainment? 2Health News:2010 Dietary Guidelines Advisory Committee Meeting to Be Webcast April 29th and 30th 2Health News:The Christ Hospital Selects Perot Systems for Revenue Cycle Solutions 2Health News:The Christ Hospital Selects Perot Systems for Revenue Cycle Solutions 3Health News:Nationwide Foundation Donates $1.7 Million to American Red Cross for Disaster Preparedness and Response and Increased Blood Collections 2Health News:Nationwide Foundation Donates $1.7 Million to American Red Cross for Disaster Preparedness and Response and Increased Blood Collections 3Health News:Nationwide Foundation Donates $1.7 Million to American Red Cross for Disaster Preparedness and Response and Increased Blood Collections 4
(Date:4/23/2015)... 2015  AbbVie (NYSE: ABBV ) has announced ... accepted its New Drug Application (NDA) and granted priority ... treatment of ombitasvir, paritaprevir, ritonavir (OBV/PTV/r), with ribavirin (RBV). ... chronic genotype 4 (GT4) hepatitis C virus (HCV) infection. ... therapy being evaluated by the FDA for patients in ...
(Date:4/23/2015)... April 23, 2015 /CNW/ - Health Canada is working ... to update the safety information regarding the risk of ... when these products are used at high doses (at ... and duration of use. Ibuprofen is a ... relief, and to reduce inflammation. The majority of ibuprofen ...
(Date:4/23/2015)... Surna, Inc. (OTCQB: SRNA), a technology company ... and systems for controlled environment agriculture ("CEA") with ... host a shareholder conference call to discuss its ... PM Eastern Standard Time/1:15 PM Pacific Standard Time. ... listen-in only, but will include a Q&A session ...
Breaking Medicine Technology:U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 2U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 3U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 4U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 5U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 6U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 7Information Update - New safety information for prescription-strength ibuprofen: Risk of heart attack and stroke at high doses 2Information Update - New safety information for prescription-strength ibuprofen: Risk of heart attack and stroke at high doses 3Information Update - New safety information for prescription-strength ibuprofen: Risk of heart attack and stroke at high doses 4Surna, Inc. Announces Shareholder Conference Call 2Surna, Inc. Announces Shareholder Conference Call 3
... BEIJING , July 15 /PRNewswire-Asia/ -- Sinovac Biotech ... China , announced today that it,held its 2010 Annual Meeting of ... Beijing Time. The required quorum, a majority of the ... was held,concurrently at No. 39 Shangdi Xi Road, Haidian District, ...
... SUNNYVALE, Calif. , July 15 Premier ... and 67,000-plus other healthcare sites working together to achieve ... provider of FDA-cleared Electronic Brachytherapy Systems, announced the execution ... exclusive three-year contract for brachytherapy systems with Premier Purchasing ...
Cached Medicine Technology:Sinovac Holds 2010 Annual Meeting of Shareholders 2Xoft Announces Exclusive Contract With Premier for Electronic Brachytherapy 2Xoft Announces Exclusive Contract With Premier for Electronic Brachytherapy 3
Comprehensive range of integrated implants and instruments including - Basic, Small, Mini, Pelvic and Foot Sets....
... international engineering and design specifications, Smith ... System* provides seamless integration with existing ... open reduction internal fixational procedures (AO ... well beyond the standard, providing a ...
... has been developed for the transvenous closure ... venous sheaths the device offers a safe ... of ASD's with a super low profile.,A ... twelve arm device for optimal positioning and ...
Stainless steel threaded Steinman Pins available in point types A,D, E, and F....
Medicine Products: