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JCI online early table of contents: August 2, 2010
Date:8/2/2010

land known as chromaffin cells secreted larger amounts of catecholamines, 'fight-or-flight' hormones such as adrenaline and noradrenaline. The authors therefore conclude that TRPM4 limits catecholamine release from chromaffin cells and that disruption of this control, as in mice lacking TRPM4, increases blood pressure.

TITLE: Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice

AUTHOR CONTACT:
Marc Freichel
Universitt des Saarlandes, Homburg, Germany.
Phone: 49.6841.16.26438; Fax: 49.6841.16.26402; E-mail: marc.freichel@uks.eu.

View this article at: http://www.jci.org/articles/view/41348?key=a8192406a2080917cfba


INFECTIOUS DISEASE: New way to control TB?

Tuberculosis is caused by infection with the bacterium M. tuberculosis. The hallmark of infection is the presence of granulomas (small nodular aggregations of inflammatory cells) in the lungs. Some of these cells, known as macrophages, are infected with M. tuberculosis, which they are desperately trying to kill. One mechanism by which macrophages kill M. tuberculosis is to produce nitric oxide. However, for this to be effective it requires high levels of oxygen, and some granulomas are oxygen deficient (hypoxic).

A team of researchers, led by Stephen Reece and Stefan Kaufmann, at the Max Planck Institute for Infection Biology, Germany, has now identified a way in which M. tuberculosis is killed in hypoxic granulomas in mice. Specifically, they found that hypoxic granulomas contained large amounts of proteins known as serine proteases, which function to degrade other proteins, and that inhibiting these proteases increased bacterial growth. The authors suggest that boosting serine protease activity could represent an attractive approach to treat tuberculosis.

TITLE: Serine p
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Contact: Karen Honey
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Journal of Clinical Investigation
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