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JCI online early table of contents: August 2, 2010
Date:8/2/2010

ns to which hormones bind (so called triple-negative tumors [TNTs]) are associated with poor clinical outcomes. A team of researchers, led by Eldad Zacksenhaus, at Toronto General Research InstituteUniversity Health Network, Toronto, has generated new insight in mice into the genetic mutations that lead to the formation of different breast cancer subtypes.

Specifically, the team found that loss of the Rb gene in mouse breast tissue progenitor cells led to luminal-B and TNT breast tumor subtypes but that the TNT tumors also had mutations in p53. They therefore conclude that Rb loss can cause breast cancer in mice and that the presence or absence of other mutations, such as mutations in p53, determine the subtype.

TITLE: Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status

AUTHOR CONTACT:
Eldad Zacksenhaus
Toronto General Research Institute University Health Network, Toronto, Ontario, Canada.
Phone: 416.340.4800, extension 5106; Fax: 416.340.3453; E-mail: eldad.zacksenhaus@utoronto.ca.

View this article at: http://www.jci.org/articles/view/41490?key=23416425fb28f873d637


CARDIOVASCULAR DISEASE: Keeping blood pressure down with the TRPM4 protein

High blood pressure is a risk factor for many diseases of the blood vessels and heart (i.e, cardiovascular diseases), including stroke, heart attack, and heart failure. However, in most patients the cause of high blood pressure is unknown. A team of researchers, led by Marc Freichel, at Universitt des Saarlandes, Germany, has now identified a role for TRPM4 proteins in regulating blood pressure in mice.

The team found that mice lacking TRPM4 had an impaired ability to keep their blood pressure down and that this was because cells in the adrenal g
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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