Navigation Links
JCI online early table of contents: August 2, 2010
Date:8/2/2010

EDITOR'S PICK: Boosting the efficacy of anticancer vaccines

There are several challenges to be overcome if therapeutic anticancer vaccines, which are designed to boost the patient's anticancer immune response, are to be successfully developed. For example, the viruses used to deliver the tumor protein to the patient's immune system are themselves targeted by the patient's immune system, inducing neutralizing and suppressive responses. But now, a team of researchers, led by Michael Morse, at Duke University Medical Center, Durham, has developed a way to overcome these neutralizing and suppressive responses by using an alphavirus packaged in virus-like replicon particles. Repeated administration of such particles carrying the tumor protein CEA to patients with metastatic cancer expressing CEA induced clinically relevant immune responses targeted to CEA. As the presence of such immune responses was associated with longer overall patient survival, the authors hope their approach might be of therapeutic use in many cancer settings.

TITLE: An alphavirus vector overcomes the presence of neutralizing antibodies and elevated numbers of Tregs to induce immune responses in humans with advanced cancer

AUTHOR CONTACT:
Michael A. Morse
Duke University Medical Center, Durham, North Carolina, USA.
Phone: 919.681.3480; Fax: 919.681.7970; E-mail: morse004@mc.duke.edu.

View this article at: http://www.jci.org/articles/view/42672?key=6b32a2643b93a9932287


ONCOLOGY: Genetic mutations determine breast cancer subtype

Breast cancers can be divided into different subtypes based on several criteria, including the marker proteins they express. Different tumor subtypes are associated with different clinical outcomes; for example, breast cancers lacking expression of the protei
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6

Related medicine news :

1. New online community launched to help medical practices learn about meaningful use
2. JCI online early table of contents: July 12, 2010
3. Online coverage of XVIII International AIDS Conference to include daily webcasts, live coverage, podcasts and news recaps
4. Sam's Club Tests Online Small Business Loan Program for Main Street
5. SNM cautions that Canadas Chalk River coming back online will not solve long-term isotope shortage
6. Suite 101.com Provides Insight Into Consumer Reading Behavior Online
7. Grand Opening of GreenProductsandGifts.com Online Store Offering Eco Friendly Gifts that are Proudly Made in the USA
8. Vibration Exercise Equipment Available at Fitness4HomeOnline.com
9. Onlineshoes.com and New Balance Pair Up for Toning Shoes Giveaway
10. Online Deals on Golf, now in Full Swing at GolfAdventures.com
11. BVibrantNow, A New All-Natural Health Supplement Business, Launches Free Online Wellness Calendar to Promote Healthy Habits
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... December 22, 2014 Fad diets ... The reason why most fad diets have hung around ... problem with fad diets is that, as the body becomes ... dieter uncertain of how to reset the metabolism to return ... Diet Doc developed their all-inclusive diet plans that ...
(Date:12/22/2014)... York, New York (PRWEB) December 22, 2014 ... are a staple of the season. Many may be thinking ... in a span of a few weeks. Health Republic Insurance ... help of Registered Dietitian, Andrea Chernus, to provide some smart ... eat and stay healthy. , 1)    Avoid arriving at a holiday ...
(Date:12/22/2014)... 2014 The Bob Woodruff Foundation ... invested more than $5 million in programs and ... their families. , This includes $1.3 million in ... helping with: veteran entrepreneurship; community impact; vocational training; ... severely injured veterans. , “The needs of those ...
(Date:12/22/2014)... 2014 In recognition of Veteran’s Day, ... Hero Reward, a local organization that provides services to ... , Located on a couple hundred acres in the ... lodging, world class fishing, hunting, hiking, horseback riding, 4-wheeling, ... several years ago to support U.S. Service men and ...
(Date:12/22/2014)... TX (PRWEB) December 22, 2014 TheHardwareCity.com ... work glove with many useful features. Customers of the ... can have the new gloves delivered to their home ... gear and hand tools that incorporate heavy duty magnets, ... Magnetic Glove allows workers to store metal parts on ...
Breaking Medicine News(10 mins):Health News:Diet Doc Announces the Difference Between Fad Diets and Real Weight Loss Programs to Help Dieters Make the Best Choice 2Health News:Diet Doc Announces the Difference Between Fad Diets and Real Weight Loss Programs to Help Dieters Make the Best Choice 3Health News:Diet Doc Announces the Difference Between Fad Diets and Real Weight Loss Programs to Help Dieters Make the Best Choice 4Health News:Health Republic Insurance of New York Offers Five Simple Tips to Eat Healthy During the Holidays 2Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 2Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 3Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 4Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 5Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 6Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 7Health News:Discount Labels Donates Portion of November Sales to Hero Reward Program 2Health News:MagnoGrip Pro Utility Magnetic Gloves on Sale at TheHardwareCity.com 2
... Sciences' Institute of Medicine released a report recommending ... the school environment, such as a la carte ... National Dairy Council (NDC) applauds the overall recommendations ... of nonfat and low-fat dairy products, fruits, vegetables ...
... are blind to the perils of imported eye cosmetics//. ... such eye makeup products known as kajal, kohl and surma ... These products used traditionally by ladies to beautify the eyes ... toxin. Lead poisoning can lead to cognitive ...
... most comprehensive look at genetic risk factors for type ... close collaboration with two other groups, has identified// at ... of diabetes and confirmed existence of another six. The ... the online edition of the journal Science, boost to ...
... a cure for the dreaded elephantiasis, Finnish scientists say. Finnish ... elephantiasis. And if only they could check the spread of ... a lasting cure for the dreaded elephantiasis. They ... than 100 km from the Arctic Circle. "From trying to ...
... Researchers from MetroHealth Medical Center and Case Western Reserve ... who have had previous spontaneous preterm births with 17 ... another preterm birth would consequently reduce both short-term and ... year. The results of their study are reported in ...
... Despite widespread capacity to provide prescription medication labels in ... do so and as a result//, limited-English patients face ... by The New York Academy of Medicine presented today ... Internal Medicine (SGIM) in Toronto, Ontario. ,"Imagine, ...
Cached Medicine News:Health News:National Academy of Sciences' Institute of Medicine Report Calls for More Dairy Foods at School 2Health News:Researchers Identify New Genetic Risk Factors for Type 2 Diabetes 2Health News:Researchers Identify New Genetic Risk Factors for Type 2 Diabetes 3Health News:Researchers Identify New Genetic Risk Factors for Type 2 Diabetes 4Health News:Researchers Identify New Genetic Risk Factors for Type 2 Diabetes 5Health News:Researchers Identify New Genetic Risk Factors for Type 2 Diabetes 6Health News:Reindeers Could Hold the Key to Elephantiasis Cure 2Health News:Reindeers Could Hold the Key to Elephantiasis Cure 3Health News:Drug Therapy can Reduce Preterm Births and Decrease Lifetime Medical Costs 2Health News:Many NYC Pharmacies Fail to Translate Prescription Labels for Patients Who Don't Understand English 2Health News:Many NYC Pharmacies Fail to Translate Prescription Labels for Patients Who Don't Understand English 3
(Date:12/19/2014)... , Dec. 19, 2014 You,re visiting ... checkup and cleaning when he or she says you ... probably heard before, you may have several questions and ... be relieved to know it,s nothing to worry about. ... patients, questions and alleviate any anxiety the public may ...
(Date:12/19/2014)... , Dec. 19, 2014   Hospira, Inc. ... provider of injectable drugs and infusion technologies, today announced ... 33rd Annual Healthcare Conference on Wednesday, Jan. 14, 2015, ... is scheduled to begin at 10:30 a.m. Pacific time ... to all interested parties through a live audiocast accessible ...
(Date:12/19/2014)... 19, 2014  Monarch America Inc. (OTCQB: CANK) ("Monarch ... pleased to provide this review of the Company,s recent ... "Over this past year, we achieved many ... extremely proud to say that Monarch America is in ... has ever been," stated Eric Hagen , CEO ...
Breaking Medicine Technology:Root Canals Have Become More Routine 2Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 2Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 3
... Mass., Sept. 16, 2011 Hologic, Inc. (Hologic or ... developer, manufacturer and supplier of premium diagnostic products, medical ... healthcare needs of women, will focus on two new, ... International Papillomavirus Conference & Clinical Workshop (IPV) ...
... Siemens has appointed Kurt D. Bettenhausen Senior Vice ... research & development (R&D) division. Siemens Corporate Research ... emerging technologies, including new imaging processes that allow ... efficiency to reduce building energy consumption, and renewable ...
Cached Medicine Technology:Hologic Launches Automated Cervical Cancer Screening Solutions at IPV Meeting in Berlin 2Hologic Launches Automated Cervical Cancer Screening Solutions at IPV Meeting in Berlin 3Hologic Launches Automated Cervical Cancer Screening Solutions at IPV Meeting in Berlin 4Siemens Appoints New R&D Head for the U.S. 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: