Navigation Links
JCI online early table of contents: Aug. 1, 2008
Date:8/1/2008

EDITOR'S PICK: Overcoming inhibitors of cell death improves cancer therapy efficacy

Individuals with glioblastoma multiforme (GBM), one of the most aggressive types of brain tumor, have an extremely poor prognosis. Although pre-clinical studies indicated therapeutics inhibiting a group of proteins known as receptor tyrosine kinases (RTKs) would likely be beneficial to individuals with GBM, these RTK inhibitors have met with limited clinical success only a small proportion of patients respond to such treatment and most subsequently relapse after only a short time. New data, generated by Andrew Kung and colleagues, at the Dana-Farber Cancer Institute, Boston, have now provided insight into the mechanism by which GBM cells become resistant to RTK inhibitors and have suggested a way to improve the efficacy of RTK inhibitors in this clinical setting.

In the study, human GBM cells exposed in vitro to an inhibitor of the RTK PDGFR activated a cellular pathway that usually induces cells to undergo a form of cell death known as apoptosis, but the final steps of the pathway were not completed, meaning that the cells did not die. Further analysis revealed that the final steps of this pathway were blocked by a group of proteins known as IAPs. Consistent with this, if the PDGFR inhibitor was combined with an IAP inhibitor the GBM cells underwent apoptosis. Further, this drug combination showed enhanced efficacy at inhibiting tumor growth in an orthotopic mouse model of GBM. The authors therefore suggest that combining drugs targeting IAPs with RTK inhibitors might prove beneficial to individuals with GBM.

TITLE: Resistance of human glioblastoma multiforme cells to growth factor inhibitors is overcome by blockade of inhibitor of apoptosis proteins

AUTHOR CONTACT:
Andrew L. Kung
Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Phone: (617) 632-5731; Fax: (617) 582-8096; E-mail:

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. HIV denialists spread misinformation online -- consequences could be deadly; and more
2. Consequences of online HIV denial; and more
3. Online Epidemic Gives Clues to Bird Flu Spread
4. MedHelp to Add Top Stanford Surgeons and Specialized Forums to Online Health Community
5. Online Celebrity Shoe Charity Auction for Womens Heart Health Opens Bidding
6. Syndicom to Launch Online Community for DePuy Spine
7. Elder Caregiving Site ShirleyBOARD.com Wins WebAward for Outstanding Online Community
8. Peer-Reviewed, Online Database Showcases Local, County and State Pandemic Planning
9. CIGNA Behavioral Health Offers Members Online Provider Profiles
10. Dynamic Energy Systems Goes Online and On-Demand
11. North Shore-LIJ Health System Begins Online Posting of Hospital Infection Rates, Other Performance Information
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... 12, 2014 The Passenger Information System ... 2013 to $20,341.36 million by 2019, at an expected ... 2019. , The public transport infrastructure in North America ... available in almost every corner of the region. The ... of public transport service providers are driving the North ...
(Date:7/12/2014)... The rise in the number of mobility devices ... architectures to suit the upsurge. Virtualization has become a ... storage technologies. The data traffic has increased by several ... has resulted in larger and more complex networks. These ... SDN market. , The North American (NA) region is ...
(Date:7/12/2014)... Thompson HealthDay Reporter SATURDAY, ... guarantee that a surgical technique used to grind up uterine ... risk of spreading cancer to other parts of a woman,s ... to the Food and Drug Administration also said that women ... -- should sign a written consent stating that they understand ...
(Date:7/12/2014)... 12, 2014 In this ... ‘cognitive assessment and training’ is defined as ... train, or enhance cognitive functions. These solutions ... in dementia screening, clinical trials, driver’s safety, ... self assessment, brain training, and employers’ assessment ...
(Date:7/12/2014)... The Security Analytics market is estimated to grow ... 2019, at an expected CAGR of 9.7% for the ... the increasing number of security breaches, continued line of ... in organizations are enormous. Vendors in the security analytics ... to develop better and more secure systems. , There ...
Breaking Medicine News(10 mins):Health News:North America Passenger Information System (ICT) Market worth $5,486.88 Million by 2019 - New Report by MicroMarket Monitor 2Health News:North America Passenger Information System (ICT) Market worth $5,486.88 Million by 2019 - New Report by MicroMarket Monitor 3Health News:North America Passenger Information System (ICT) Market worth $5,486.88 Million by 2019 - New Report by MicroMarket Monitor 4Health News:North America Software Defined Network (SDN) Market Worth $1,443.8 Million by 2019 - New Report by MicroMarket Monitor 2Health News:North America Software Defined Network (SDN) Market Worth $1,443.8 Million by 2019 - New Report by MicroMarket Monitor 3Health News:North America Software Defined Network (SDN) Market Worth $1,443.8 Million by 2019 - New Report by MicroMarket Monitor 4Health News:North America Software Defined Network (SDN) Market Worth $1,443.8 Million by 2019 - New Report by MicroMarket Monitor 5Health News:FDA Advisers Weigh Risks of Procedure for Removal of Uterine Fibroids 2Health News:FDA Advisers Weigh Risks of Procedure for Removal of Uterine Fibroids 3Health News:Global Cognitive Assessment & Training Market: 27.3% CAGR to 2018 Says a New Research Report Available at LifeScienceIndustryResearch.com 2Health News:Global Cognitive Assessment & Training Market: 27.3% CAGR to 2018 Says a New Research Report Available at LifeScienceIndustryResearch.com 3Health News:Global Cognitive Assessment & Training Market: 27.3% CAGR to 2018 Says a New Research Report Available at LifeScienceIndustryResearch.com 4Health News:Global Cognitive Assessment & Training Market: 27.3% CAGR to 2018 Says a New Research Report Available at LifeScienceIndustryResearch.com 5Health News:North America Security Analytics Market Worth $1,215.2 Million by 2019 - New Report by MicroMarket Monitor 2Health News:North America Security Analytics Market Worth $1,215.2 Million by 2019 - New Report by MicroMarket Monitor 3Health News:North America Security Analytics Market Worth $1,215.2 Million by 2019 - New Report by MicroMarket Monitor 4
... market most aggressively to physicians and patients tend to offer ... phenomenon described as the "inverse benefit law" in a paper ... Published online Thursday, Jan. 13 in the American ... of blockbuster drugs due to safety concerns and finds a ...
... By Amanda Gardner HealthDay Reporter , THURSDAY, Jan. ... heartening medical progress continued to arrive Thursday, five days after ... an assassin,s bullet. Giffords, doctors at University Medical Center ... keep her eyes open for up to 15 minutes at ...
... (HealthDay News) -- Differences in income, gender and race ... prematurely, a federal government report released Thursday shows. ... live healthy lives, disparities persist, according to the U.S. ... low-income people have five to 11 times fewer healthy ...
... from training programs that put them behind the wheelin a ... skills. That,s the conclusion of a new article published in ... the Association for Psychological Science. Older people are ... Some states and provinces test older drivers, hoping to get ...
... AMES, Iowa Advancements in understanding rotational motion in ... causes of deadly diseases, such as Alzheimer,s, according to ... of Energy,s Ames Laboratory and faculty member at Iowa ... article entitled "Resolving Rotational Motions of Nano-objects in Engineered ...
... Virginia Tech-Wake Forest University Center for Injury Biomechanics ( ... from the U.S. Army Medical Research and Materiel Command ... brain and eye injuries in military personnel. Specifically, blast ... computational models. Given improvements in helmet design and body ...
Cached Medicine News:Health News:Inverse benefits due to drug marketing undermine patient safety and public health 2Health News:Inverse benefits due to drug marketing undermine patient safety and public health 3Health News:Rep. Giffords Continues to Recover From Gunshot Wound 2Health News:Rep. Giffords Continues to Recover From Gunshot Wound 3Health News:Health Disparities Persist in U.S., Report Shows 2Health News:Driving simulators help older adults improve their road skills 2Health News:New tool for cell research may help unravel secrets of disease 2Health News:US Department of Defense supports study of brain, eye injuries in military personnel 2
(Date:7/10/2014)... July 10, 2014  BC Technical, the largest nationwide, ... America , Inc., a leading provider of Siemens Nuclear ... long-term agreement naming BC Technical as the authorized provider ... MiE and BC Technical announced today that the ... BC Technical as the service and systems provider for ...
(Date:7/10/2014)... BURLINGTON, Mass. , July 10, 2014 /PRNewswire/ ... three-quarters of surveyed infectious disease (ID) specialists are ... Medicines Company,s Orbactiv (oritavancin) for use as OPAT, ... to prescribe these agents to their hospital inpatients. ... percent) of OPAT patients are initiated on OPAT ...
(Date:7/10/2014)... , July 10, 2014 Decision Resources ... awareness of the U.S. Food and Drug Administration,s (FDA) ... phosphate binder Velphoro, which was approved by the FDA ... chronic kidney disease (CKD) patients on dialysis. ... TreatmentTrends: Nephrology (US) Q2 2014 : ...
Breaking Medicine Technology:BC Technical Partners With MiE America To Be Authorized Provider Of Systems & Service 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 3Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 2Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 3
... STEVENSVILLE, Md., July 13, 2011 Vapotherm, a privately held ... announced today that it has received approval from the Medical ... device which will be launched later this year in the ... Flow Specialty Gas Program. "We are pleased ...
... 2011 The U.S. Food and Drug Administration today ... and patients that surgical placement of mesh through the ... to greater risk than other surgical options. ... communication also says that with the exposure to greater ...
Cached Medicine Technology:Vapotherm Announces Approval in Canada for New High Flow Device Designed for Heliox 2FDA: Surgical Placement of Mesh to Repair Pelvic Organ Prolapse Poses Risks 2FDA: Surgical Placement of Mesh to Repair Pelvic Organ Prolapse Poses Risks 3FDA: Surgical Placement of Mesh to Repair Pelvic Organ Prolapse Poses Risks 4
Ambion's barrier tips prevent cross-contamination of samples by means of an aerosol filter. They are RNase- and DNase-free and are ideal for handling RNA, PCR applications, and for working with radio...
10 L, Bulk Recommended for 5 and 10 L pipettes. Ideal for pipetting into long, narrow tubes or deep well plates....
This extended 10 L tip additionally combats contamination by keeping your pipettor out of 1.5 L and 2.0 L tubes....
1000 L, Bulk Recommended for 500 and 1000 L pipettes....
Medicine Products: