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JCI online early table of contents: April 6, 2009
Date:4/6/2009

dward E.S. Nieuwenhuis
Erasmus Medical Center, Rotterdam, The Netherlands.
Phone: 31-10-7037093; Fax: 31-10-7036811; E-mail: e.nieuwenhuis@erasmusmc.nl.

View the PDF of this article at: https://www.the-jci.org/article.php?id=36509


PHYSIOLOGY: A link between low oxygen levels and intestinal iron absorption

The only way for iron, which is an essential nutrient, to be taken up by the body is for it to be absorbed by the intestine. Low iron levels can lead to anemia, which is characterized by weakness and fatigue and, in severe cases, heart failure. In a new study, Carole Peyssonnaux and her colleagues at Universit Paris Descartes, France, have identified a link between one of the HIF proteins that help cells adapt to low oxygen levels (hypoxia) and iron absorption in the small intestine, which they found was hypoxic. Using transgenic mice, they showed that HIF-2-alpha (but not HIF-1-alpha) helped maintain iron levels in the intestine by regulating expression of the primary iron transporter gene. Furthermore, mice lacking HIF-2-alpha displayed low levels of iron in the blood and liver. The authors therefore conclude that strategies targeting HIF-2-alpha may be useful in treating patients with iron disorders.

TITLE: HIF-2-alpha, but not HIF-1-alpha, promotes iron absorption in mice

AUTHOR CONTACT:
Carole Peyssonnaux
Universit Paris Descartes, CNRS (UMR 8104), Paris, France.
Phone: 33-1-44-41-24-52; Fax: 33-1-44-41-24-21; E-mail: carole.peyssonnaux@inserm.fr.

View the PDF of this article at: https://www.the-jci.org/article.php?id=38499


NEPHROLOGY: Fragmenting mitochondria underlie acute kidney failure

Damage to kidney cells known
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Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

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