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JCI online early table of contents: April 6, 2009
Date:4/6/2009

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View the PDF of this article at: https://www.the-jci.org/article.php?id=36022


GASTROENTEROLOGY: The protein Cd1d controls intestinal colonization with bacteria

The intestines of all mammals, including humans, are home to a large number of species of bacteria. The identity of these bacteria affects both the normal functioning of the intestines and the occurrence of immune-mediated intestinal diseases, such as inflammatory bowel disease. Despite the importance of these bacteria, little is known about the host factors that control their colonization of the intestines. However, Edward Nieuwenhuis and colleagues, at Erasmus Medical Center, The Netherlands, have now identified a role for the protein Cd1d in regulating intestinal colonization by bacteria in mice.

In the study, when analyzed under specific pathogenfree or germ-free conditions and compared with Cd1d-sufficient mice, Cd1d-deficient mice exhibited increased colonization of the small intestine following administration of a number of species of bacteria (Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, or Lactobacillus gasseri) into their stomachs. By contrast, activation of immune cells that bind Cd1d prevented intestinal colonization of specific pathogenfree Cd1d-sufficient mice with P. aeruginosa and E. coli. Further analysis revealed a role for Paneth cells, which are found only in the small intestine, in the process. The authors therefore conclude that Cd1d controls colonization of the intestines with bacteria via a mechanism that involves Paneth cells and suggest that manipulating Cd1d might provide a way to modulate the identity of the bacteria in the intestines.

TITLE: Cd1d-dependent regulation of bacterial colonization in the intestine of mice

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