Navigation Links
JCI online early table of contents: April 6, 2009
Date:4/6/2009

EDITOR'S PICK: Separating the beneficial effects of a drug from the adverse side effects

Nicotinic acid is one of the most effective drugs for raising levels of "good" cholesterol and lowering levels of "bad" cholesterol and other lipids (fats), thereby reducing the risk of heart attack. However, patients often stop taking the drug due to one specific side effect, flushing of the skin that often includes an intense burning and itching sensation. A way to separate the beneficial effects of nicotinic acid from the flushing response has now been elucidated in mice by Robert Lefkowitz and colleagues, at Duke University Medical Center, Durham.

In the study, analysis of human cell lines determined a signaling pathway by which nicotinic acid could initiate the flushing response. This pathway involved the recruitment of beta-arrestin proteins to the GPR109A receptor to which nicotinic acid binds. Interestingly, mice lacking beta-arrestin1 showed a decreased flushing response when treated with nicotinic acid, but the drug retained its beneficial effects on the levels of lipids in the blood. The authors therefore suggest that designing a drug that binds GPR109A but does not stimulate the recruitment of beta-arrestin1 might result in a therapeutic that has beneficial effects on lipid levels without the side effect of flushing.

TITLE: Beta-Arrestin1 mediates nicotinic acidinduced flushing, but not its antilipolytic effect, in mice

AUTHOR CONTACT:
Robert J. Lefkowitz
Duke University Medical Center, Durham, North Carolina, USA.
Phone: (919) 684-3755; Fax: (919) 684-8875; E-mail: lefko001@receptor-biol.duke.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=36806


ONCOLOGY: Harnessing immune cells to target skin cancer

One subset of immune c
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Penn Foster Launches Online High School Diploma Program with a Healthcare Career Focus
2. Deloitte Survey Finds Healthy Consumer Demand For Electronic Health Records, Online Tools and Services
3. Medical Doctor Enhances Health Awareness through Online Blogging
4. Rxonlinetoday Launch Cyber Shop for FDA Approved Medicines
5. Thousands of Health Care Providers Enhance Online Profiles
6. CardioCareLive.com, First Ever Online Cardiometabolic Conference, Revolutionizes Continuing Medical Education for Cardiovascular Healthcare Professionals
7. PennDOT: Fast, Easy Online Organ Donor Registration Could Help Save a Life
8. An Online Guide to Cope With Recession-Related Stress
9. New Online Program Helps Parents Tackle Childhood Obesity
10. HealthForumOnline Offers New Online CE Course on Working with Transgender Individuals
11. 23andMe Launches Free Online Community for Moms and Moms-to-Be
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/4/2015)... 04, 2015 Rocket Builders’ “Ready to ... companies that have the best prospect for growth according ... we choose the Ready to Rocket companies, we are ... innovation with market opportunity. Prizm Media Inc. is an ... customers at the right time,” said Reg Nordman, Managing ...
(Date:3/4/2015)... (PRWEB) March 04, 2015 The medical ... companies whose management forgot – or ignored or didn't ... Validate the market based on physician input before proceeding ... – more specifically, founders – become so enamored of ... key question: Will physicians use the device?” says ...
(Date:3/3/2015)... Centerville, MA (PRWEB) March 04, 2015 ... and educational facilities design and construction event for ... Hotel Boston Massachusetts announced key building envelope related ... credits. , Workshops include: , Curtain ... installed in many health care and laboratory facilities ...
(Date:3/3/2015)... 03, 2015 Anik Singal's ... program for ambitious online marketers has become the ... community. Widespread media attention surrounding the course's general ... reporter Tiffany Hendricks, prompting her to review the ... , "One of the biggest keys to success ...
(Date:3/3/2015)... NOVAtime Technology, Inc. ( http://www.novatime.com ... Attendance / Workforce Management solutions, announced that Innovative ... Workforce Management / Time and Attendance system ... , Since 2004, Innovative Services’ mission has been ... best quality of life. The company is committed ...
Breaking Medicine News(10 mins):Health News:Healthcare Lead Generation Leader Prizm Media Inc. is “Ready to Rocket” 2Health News:Healthcare Lead Generation Leader Prizm Media Inc. is “Ready to Rocket” 3Health News:Want to Succeed in Medical Technology? Don't Innovate in a Vacuum 2Health News:Want to Succeed in Medical Technology? Don't Innovate in a Vacuum 3Health News:Building Envelope Code and Regulation Sessions at MED-Ed Facilities 2Health News:Building Envelope Code and Regulation Sessions at MED-Ed Facilities 3Health News:Building Envelope Code and Regulation Sessions at MED-Ed Facilities 4Health News:Building Envelope Code and Regulation Sessions at MED-Ed Facilities 5Health News:Building Envelope Code and Regulation Sessions at MED-Ed Facilities 6Health News:Anik Singal's Profit Academy - Review Of New IM Training Program Released 2Health News:Innovative Services, Inc. Successfully Migrates to Cloud-Based NOVAtime Workforce Management Solution to Support Growth and Improve Payroll Processing Time 2Health News:Innovative Services, Inc. Successfully Migrates to Cloud-Based NOVAtime Workforce Management Solution to Support Growth and Improve Payroll Processing Time 3
... Dynamics Company,Ltd.) (TSX: IDL), the global leader in ... that it has been awarded a contract by,the ... India for,five X-Series 1600 DR systems with X4C ... placed for DR equipment by the government in,India ...
... not be the major cause of hyperactivity in children. Genetics, ... just as important. , A review ... actually affected by what they eat. A combination of food, ... with no single factor to blame. , Foods which ...
... Transplant,Foundation (MTF) will provide military hospitals with special ... for injured servicemen and,women., Military hospitals and ... for cartilage transplantation and meniscus grafts used for,joint ... tissue are in high,demand for U.S. servicemen and ...
... has awarded one of 14 Clinical and Translational Science ... Boston University Medical (BUMC) and Charles River Campuses and ... CTSAs awarded in 2007, and 12 awarded in 2006, ... a national consortium of select centers that will transform ...
... H. Antman, MD, provost of Boston University Medical Campus ... be honored with the Distinguished Service Award for Scientific ... at their annual meeting in Chicago this weekend. Antman, ... cancer, is widely recognized for her development of a ...
... a Useful Tool in Detection, as Sensitive as MRI ... Invasive Cancers and Perhaps More So for DCIS, NEWPORT ... June issue of Radiology, researchers at The George Washington,University Medical ... is highly sensitive in detecting the,presence of cancer. The researchers ...
Cached Medicine News:Health News:IDC awarded India's largest state government contract for digital radiography systems 2Health News:IDC awarded India's largest state government contract for digital radiography systems 3Health News:Children's diet not the main cause of ADHD 2Health News:BUMC, BMC receives Clinical and Translational Science Award from NIH 2Health News:BUMC provost, BUSM dean, to be honored at world's largest meeting of oncology professionals 2Health News:Breast-Specific Gamma Imaging (BSGI) Found to Be Highly Sensitive for Early Stage Breast Cancer 2
(Date:3/3/2015)... 3, 2015  Columbia Laboratories, Inc. (Nasdaq: ... Company"), a specialty pharmaceutical company focused on pharmaceuticals for ... the 27th Annual ROTH Conference, which will take place ... Dana Point, California . Management,s presentation ... a.m. Pacific Time (12:00 p.m. Eastern Time) in the ...
(Date:3/3/2015)... 2015  Web Industries, Inc., a leading provider ... Medical Device, Advanced Composites, Consumer Products, and Wire ... Medical Specialties Preferred Converter by 3M,s Medical Specialties ... to streamline their supply chains by using Web ... materials, intermediate converting services, and contract manufacturing and ...
(Date:3/3/2015)... 2015 Research and Markets ( ... "Global Ultrasound Equipment Market 2015-2019" report ... The Global Ultrasound Equipment market to grow at ... Ultrasound equipment are used to examine ... extensively used by cardiologists, radiologists, surgeons, obstetricians, and ...
Breaking Medicine Technology:Web Industries Receives 3M Preferred Converter Status 2Global Ultrasound Equipment Market 2015-2019: Rise in Number of MI Diagnostic Procedures with GE Healthcare, Phillips Healthcare, Siemens Healthcare & Toshiba Medical Systems Dominating 2
... (OTC Bulletin Board: AEMD ), the pioneer in ... announced today that its Chairman and Chief Executive Officer, Jim ... Investment Conference at 3:40 p.m. EDT on September 14, 2010. ... Hotel in New York City from September 12-15, 2010. Additional ...
... Aug. 30 Brothers blow the numbers away. ... short years ago and have never looked back. ... (Logo:   http://photos.prnewswire.com/prnh/20100817/INC5000LOGO ) (Logo:  http://www.newscom.com/cgi-bin/prnh/20100817/INC5000LOGO) ... provider of low cost ultrasound systems in the ...
Cached Medicine Technology:Aethlon Medical to Present at Rodman & Renshaw Annual Global Investment Conference 2Aethlon Medical to Present at Rodman & Renshaw Annual Global Investment Conference 3Aethlon Medical to Present at Rodman & Renshaw Annual Global Investment Conference 4Aethlon Medical to Present at Rodman & Renshaw Annual Global Investment Conference 5National Ultrasound Makes the Inc 5000 List for Third Year in a Row 2
... Vitrectomy Lenses are a family of single-use direct ... of a particular region of the retinal surface ... less than 1 gram and is formed and ... of a human cornea. Lenses come in boxes ...
... The AFX Lens is a ... use in an air-filled eye. ... as a primary air-fluid exchange ... and sutureless design make it ...
... The Chalam 30° Prism ... pathologies and are recommended for ... etc.) and Rhegmatogenus retinal detachment. ... panretinal photocoagulation and other midperipheral ...
... The 45° Prism ... fundus pathologies and are ... detachments (PDR, BRVO etc.) ... They can be used ...
Medicine Products: