Navigation Links
JCI online early table of contents: April 6, 2009
Date:4/6/2009

EDITOR'S PICK: Separating the beneficial effects of a drug from the adverse side effects

Nicotinic acid is one of the most effective drugs for raising levels of "good" cholesterol and lowering levels of "bad" cholesterol and other lipids (fats), thereby reducing the risk of heart attack. However, patients often stop taking the drug due to one specific side effect, flushing of the skin that often includes an intense burning and itching sensation. A way to separate the beneficial effects of nicotinic acid from the flushing response has now been elucidated in mice by Robert Lefkowitz and colleagues, at Duke University Medical Center, Durham.

In the study, analysis of human cell lines determined a signaling pathway by which nicotinic acid could initiate the flushing response. This pathway involved the recruitment of beta-arrestin proteins to the GPR109A receptor to which nicotinic acid binds. Interestingly, mice lacking beta-arrestin1 showed a decreased flushing response when treated with nicotinic acid, but the drug retained its beneficial effects on the levels of lipids in the blood. The authors therefore suggest that designing a drug that binds GPR109A but does not stimulate the recruitment of beta-arrestin1 might result in a therapeutic that has beneficial effects on lipid levels without the side effect of flushing.

TITLE: Beta-Arrestin1 mediates nicotinic acidinduced flushing, but not its antilipolytic effect, in mice

AUTHOR CONTACT:
Robert J. Lefkowitz
Duke University Medical Center, Durham, North Carolina, USA.
Phone: (919) 684-3755; Fax: (919) 684-8875; E-mail: lefko001@receptor-biol.duke.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=36806

ONCOLOGY: Harnessing immune cells to target skin cancer

One subset of immune c
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

1

GOOD

Page: 1 2 3 4 5

Related medicine news :

1. Penn Foster Launches Online High School Diploma Program with a Healthcare Career Focus
2. Deloitte Survey Finds Healthy Consumer Demand For Electronic Health Records, Online Tools and Services
3. Medical Doctor Enhances Health Awareness through Online Blogging
4. Rxonlinetoday Launch Cyber Shop for FDA Approved Medicines
5. Thousands of Health Care Providers Enhance Online Profiles
6. CardioCareLive.com, First Ever Online Cardiometabolic Conference, Revolutionizes Continuing Medical Education for Cardiovascular Healthcare Professionals
7. PennDOT: Fast, Easy Online Organ Donor Registration Could Help Save a Life
8. An Online Guide to Cope With Recession-Related Stress
9. New Online Program Helps Parents Tackle Childhood Obesity
10. HealthForumOnline Offers New Online CE Course on Working with Transgender Individuals
11. 23andMe Launches Free Online Community for Moms and Moms-to-Be
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/14/2009)... Dec. 14 The National Organization for Rare ... immediate end to lifetime and annual health insurance caps. ... a newspaper distributed widely on Capitol Hill, NORD ... that would allow caps to continue for most Americans, ... supports health care reform and welcomes the promises made ...
(Date:12/14/2009)... replaced tube watching , , MONDAY, Dec. 14 (HealthDay News) ... of television a week until he enrolled in a ... in half. , During his enforced period of deprivation, ... necessarily through strenuous exercise, although he did find his ... was spent reading and working on the computer, said ...
(Date:12/14/2009)... Dec. 14 Skilled nursing facilities (SNFs) in ... in order to deal with a 92 percent increase ... from $6.25 to $12.01 per bed per day, scheduled ... average facility will pay an additional $17,520 to the ... total tax of $438,365 yearly. ,, Nearly 96 percent ...
(Date:12/14/2009)... WASHINGTON, Dec. 14 The Hemophilia Federation ... ongoing labor issues involving the Teamsters Local 929 ... Jersey. The national blood system depends on skilled ... The blood is distilled into products such as ... von Willebrand disease. ,, The Division of ...
(Date:12/14/2009)... be linked to scans performed in 2007 , , MONDAY, ... exposing patients to far more radiation than previously thought and ... a year, two new studies claim. , Based on the ... Archives of Internal Medicine , the study authors, joined by ... on clinicians to limit radiation exposure to patients. , "CT ...
Breaking Medicine News(10 mins):Health News:NORD Calls for Immediate End to Lifetime Insurance Caps 2Health News:Cutting TV Time Burns More Calories 2Health News:Survey Shows Tax Increase Forcing Ohio Skilled Nursing Facilities to Make Cuts 2Health News:Survey Shows Tax Increase Forcing Ohio Skilled Nursing Facilities to Make Cuts 3Health News:HFA Voices Blood Safety Concerns 2Health News:Studies Quantify Cancer Risks From CT Scans 2Health News:Studies Quantify Cancer Risks From CT Scans 3Health News:Studies Quantify Cancer Risks From CT Scans 4
... refusal of surgery to known smokers is all set ... debating the issue in this week’s BMJ//. The issue ... trust last year to remove smokers from the waiting ... is from Concord Repatriation General Hospital in Australia feels ...
... Centre for Disease Control and Prevention (CDC) Atlanta's Division ... US changed its guidelines// and made TB tests mandatory ... have been residing there. ,Tuberculosis can only ... are tested and, if necessary, treated for latent TB ...
... published study shows that more people were at risk of ... Tom Daschle's office than previously known//. On the other hand, ... to be highly effective against the disease. ,The ... The Journal of Infectious Diseases, now available online. ...
... fight pandemic avian flu in humans could actually lead ... to avoid––drug-resistant strains of the virus in wild birds. ... in Oxford have released findings in the January 2007 ... Tamiflu’s persistence in wastewater and river water could affect ...
... Delhi: There is definitely more to it than what meets ... marriage and outside of marriage// according to the findings of ... sexes are ill informed about HIV/AIDS and protective measures, with ... wrong information. Among the sexes, boys were seen to ...
... UK, will be dishing out 7000 pounds by way of ... a magic cream supposed// to cure skin diseases. , ... Clobetasol Propionate, a prescription steroid drug, used to treat severe ... and Healthcare Products Regulatory Agency (MHRA- a government watchdog body ...
Other Medicine News:Health News:Refusal of Surgery for Smokers – To Be or Not to Be 2Health News:All Foreign-born Nationals In US To Be Tested For TB 2Health News:Anthrax Attack - Greater Potential Threat Than Thought 2Health News:Ramifications of Widespread Use of Tamiflu 2
(Date:12/14/2009)... STAMFORD, Conn., Dec. 14 Zargis Medical ... SPDE ) and a spin-off from Siemens ... today that it has begun selling its award-winning ... retailer. ,, Cardioscan and its accompanying Bluetooth®-enabled electronic ... magazine,s "2009 Innovation of the Year." ...
(Date:12/14/2009)... Southridge LLC ("Southridge"), an investment firm that provides ... announce that its affiliated fund has closed a private ... equity financing to Imaging Diagnostic Systems, Inc. (OTCBB: IMDS). ... growth of Imaging Diagnostic Systems, Southridge has paved a ... the field of early breast cancer detection," said Stephen ...
(Date:12/14/2009)... DIEGO, Dec. 14 Cardium Therapeutics (NYSE ... "Phase 2b Study of GAM501 (Ad5PDGF-B/Collagen) in the ... Wound Healing: Science and Industry Conference held December ... The conference is attended by top industry ... advanced wound healing. Dr. Barbara K. Sosnowski, ...
Breaking Medicine Technology:Zargis Cardioscan 'The Intelligent Stethoscope' Now Available on Amazon.com 2Southridge LLC Provides Funding Through Private Equity Agreement with Imaging Diagnostic Systems, Inc. 2Cardium Presents at Tenth Annual Wound Healing: Science and Industry Conference on Matrix Wound Healing Clinical Development 2Cardium Presents at Tenth Annual Wound Healing: Science and Industry Conference on Matrix Wound Healing Clinical Development 3Cardium Presents at Tenth Annual Wound Healing: Science and Industry Conference on Matrix Wound Healing Clinical Development 4Women faring well in hiring process for science faculty jobs at research universities 8695 1Women faring well in hiring process for science faculty jobs at research universities 8695 2Women faring well in hiring process for science faculty jobs at research universities 8695 3Women faring well in hiring process for science faculty jobs at research universities 8695 4Aluminum oxide nanopore beats other materials for DNA analysis 8692 1Aluminum oxide nanopore beats other materials for DNA analysis 8692 2Innovia Receives FDA Clearance For The InnoPort 28TM 29 47637 1Innovia Receives FDA Clearance For The InnoPort 28TM 29 47637 2
... Radiologists, Outpatient Procedure Uses Heat to Destroy,Lung ... ablation,(RFA) -- an interventional treatment that "cooks" ... greatly improves survival time from primary or,metastatic ... released today at,the Society of Interventional Radiology,s ...
... 17 Cardium Therapeutics,(Amex: CXM ) and ... the Phase 2b MATRIX clinical study has been ... the U.S., including television news,features in Florida, Pennsylvania, ... the safety and efficacy of Excellarate(TM) for,the potential ...
Other Medicine Technology:Treatment Gives Lung Cancer Patients With Inoperable Tumors Two Years or More 2Treatment Gives Lung Cancer Patients With Inoperable Tumors Two Years or More 3Treatment Gives Lung Cancer Patients With Inoperable Tumors Two Years or More 4Cardium and Tissue Repair Company's Excellarate Candidate for Healing Diabetic Wounds Gains Media Focus in Multiple Regions Across U.S. 2Cardium and Tissue Repair Company's Excellarate Candidate for Healing Diabetic Wounds Gains Media Focus in Multiple Regions Across U.S. 3Cardium and Tissue Repair Company's Excellarate Candidate for Healing Diabetic Wounds Gains Media Focus in Multiple Regions Across U.S. 4Cardium and Tissue Repair Company's Excellarate Candidate for Healing Diabetic Wounds Gains Media Focus in Multiple Regions Across U.S. 5Cardium and Tissue Repair Company's Excellarate Candidate for Healing Diabetic Wounds Gains Media Focus in Multiple Regions Across U.S. 6
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: