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JCI online early table of contents: April 13, 2009
Date:4/13/2009

one: 33-1-42-34-69-23; Fax: 33-1-40-51-85-86; E-mail: fabienne.foufelle@crc.jussieu.fr.

View the PDF of this article at: https://www.the-jci.org/article.php?id=37007


METABOLIC DISEASE: New role for immune system in hardening of the arteries

Atherosclerosis, or hardening of the arteries, is a chronic inflammatory disease of the major arterial blood vessels that is a common cause of heart attack and stroke. New insight into the role of the immune system in atherosclerosis has now been provided through the study of mice and humans by a team of researchers, at the University of California at San Diego, La Jolla, and the Medical University of Vienna, Austria.

The team, led by Joseph Witztum and Christoph Binder, found that immune factors known as natural Abs (NAbs) from both mice and humans recognize portions of lipoproteins, molecules that accumulate in regions of blood vessels affected by atherosclerosis. Detailed analysis in mice indicated that NAbs that bind lipoproteins also bind atherosclerotic regions of blood vessels and cells that have died by a process known as apoptosis. The authors therefore suggest that future studies should determine the role of NAbs in the development of atherosclerosis.

TITLE: Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice

AUTHOR CONTACT:
Joseph L. Witztum
University of California at San Diego, La Jolla, California, USA.
Phone: (858) 534-4347; Fax: (858) 534-2005; E-mail: jwitztum@ucsd.edu.

Christoph J. Binder
Medical University of Vienna, Vienna, Austria.
Phone: 43-1-40400-6441; Fax: 43-1-40400-2097; E-mail: christoph.binder@meduniwien.ac.at.

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Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

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