Navigation Links
JCI online early table of contents: April 13, 2009
Date:4/13/2009

s, they developed atherosclerotic lesions with massive nanoparticle accumulation. The authors therefore conclude from these results that targeting lipoprotein pintocytosis should be considered when developing novel atherosclerotic therapies that prevent macrophage uptake of lipoproteins.

TITLE: Fluorescent pegylated nanoparticles demonstrate fluid-phase pinocytosis by macrophages in mouse atherosclerotic lesions

AUTHOR CONTACT:
Howard S. Kruth
NHLBI, National Institutes of Health, Bethesda, Maryland, USA.
Phone: (301) 496-4826; Fax: (301) 402-4359; E-mail: kruthh@nhlbi.nih.gov.

View the PDF of this article at: https://www.the-jci.org/article.php?id=35548


METABOLIC DISEASE: Adding insight into nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease associated with conditions such as obesity, type 2 diabetes, and high blood pressure. It covers a spectrum of disease states, beginning with hepatic steatosis, which leads to steatohepatitis, cirrhosis, and ultimately liver cancer. Fabienne Foufelle and colleagues, at INSERM UMRS 872, Paris, have now provided new insight into the mechanisms underlying hepatic steatosis in obese insulin-resistant rodents. Specifically, they find that ER stress activates the protein SREBP-1c, which is intimately involved in hepatic lipogenesis (and thereby hepatic steatosis), explaining why ER stress has a role in hepatic steatosis. Further, they show that overexpression of the protein GRP78 inhibits both insulin and ER stressinduced activation of SREBP-1c.

TITLE: GRP78 expression inhibits insulin and ER stressinduced SREBP-1c activation and reduces hepatic steatosis in mice

AUTHOR CONTACT:
Fabienne Foufelle
INSERM UMR-S 872, Centre de Recherche des Cordeliers, Paris, France.
Ph
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6

Related medicine news :

1. HIV denialists spread misinformation online -- consequences could be deadly; and more
2. Consequences of online HIV denial; and more
3. Online Epidemic Gives Clues to Bird Flu Spread
4. MedHelp to Add Top Stanford Surgeons and Specialized Forums to Online Health Community
5. Online Celebrity Shoe Charity Auction for Womens Heart Health Opens Bidding
6. Syndicom to Launch Online Community for DePuy Spine
7. Elder Caregiving Site ShirleyBOARD.com Wins WebAward for Outstanding Online Community
8. Peer-Reviewed, Online Database Showcases Local, County and State Pandemic Planning
9. CIGNA Behavioral Health Offers Members Online Provider Profiles
10. Dynamic Energy Systems Goes Online and On-Demand
11. North Shore-LIJ Health System Begins Online Posting of Hospital Infection Rates, Other Performance Information
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Butler Mobility has recently updated the paint color choices ... Previously the two standard colors were beige and brown. ... as standard colors at no additional charge! These colors ... enhance the beauty of the stairway. Homeowners will find ... individual décor. , The new selection of standard colors is: ...
(Date:7/11/2014)... HealthDay Reporter THURSDAY, July 10, ... who was thought to be cured by immediate and aggressive ... of the AIDS-causing virus in her bloodstream, disappointed federal officials ... old, had remained virus-free even though she stopped taking HIV ... her remission would open the door to a functional cure ...
(Date:7/11/2014)... July 11, 2014 As part ... Bernstein Liebhard LLP has been closely monitoring the ... Administration’s (FDA) Obstetrics and Gynecology Devices Panel, ... mitigate the cancer risks associated with the use ... According to a report published by Dow Jones ...
(Date:7/11/2014)... 2014 Datalogic brings a new and ... hospital wide. With their new Gryphon GD4400 ... like the devastating MRSA, which claimed 5,500 lives, becomes ... 2D and the Gryphon GM4400-HC 2D readers can ... even read barcodes off of troublesome LCD monitors, smartphones, ...
(Date:7/11/2014)... 11, 2014 (HealthDay News) -- In people with sex ... similar to that seen in drug addicts as they ... clear differences in brain activity between patients who have ... those of drug addicts," study author Dr. Valerie Voon, ... a university news release. Voon,s research involved 19 ...
Breaking Medicine News(10 mins):Health News:Butler Mobility Products Announces Five New Standard Colors for Their Inclined Platform Lifts 2Health News:Mississippi Girl Thought Cured of HIV Shows Signs of Infection 2Health News:Mississippi Girl Thought Cured of HIV Shows Signs of Infection 3Health News:Morcellator Lawsuit News: Bernstein Liebhard LLP Notes Financial Ties Between FDA Advisory Panel Members and Manufacturers of Power Morcellators 2Health News:Morcellator Lawsuit News: Bernstein Liebhard LLP Notes Financial Ties Between FDA Advisory Panel Members and Manufacturers of Power Morcellators 3Health News:Morcellator Lawsuit News: Bernstein Liebhard LLP Notes Financial Ties Between FDA Advisory Panel Members and Manufacturers of Power Morcellators 4Health News:Stop Spreading Disease with the New Disinfectant-Ready Bar Code Scanner 2Health News:Stop Spreading Disease with the New Disinfectant-Ready Bar Code Scanner 3Health News:Brains of Sex Addicts May Be Wired Like Those of Drug Addicts, Study Finds 2
... publication in The Endocrine Society,s Journal of Clinical Endocrinology ... the diabetes drug metformin may prevent or delay the development ... affects 7 to 10 percent of women of childbearing age ... estimated 5 to 6 million women in the United States, ...
... HealthDay Reporter , TUESDAY, June 28 (HealthDay News) -- A ... shows some promise, while another designed to alter insulin production ... The results of both studies were slated to be presented ... Diego. Type 1 diabetes often appears early in life ...
... Md. - Four Mid-Atlantic States are teaming up to ... at replacing old, highly polluting trucks. Led by ... Management Association (MARAMA), the new program will target the ... ports, warehouses and local stores. The effort ...
... Doheny HealthDay Reporter , TUESDAY, June 28 (HealthDay ... than most experts have long believed, according to a new, ... of nearly three decades -- the longest ever -- the ... as the decades roll on. In fact, most of ...
... Health & Science University have discovered a naturally occurring disease ... humans a discovery that could have a major impact ... The disease that the researchers discovered in monkeys at ... herpes virus that could give significant clues into how multiple ...
... 28 (HealthDay News) -- Analyzing the genomes of Tasmanian ... contagious cancer, according to scientists. Tasmanian devils are ... Australian island of Tasmania. They,re being decimated by Devil ... causes death from starvation or suffocation within months. The ...
Cached Medicine News:Health News:Diabetes drug may prevent or delay development of polycystic ovary syndrome 2Health News:Trials of Type 1 Diabetes Vaccines Bring Mixed Results 2Health News:Trials of Type 1 Diabetes Vaccines Bring Mixed Results 3Health News:Mid-Atlantic states' unique plan to replace region's dirtiest trucks 2Health News:Mid-Atlantic states' unique plan to replace region's dirtiest trucks 3Health News:Longest Trial Ever Confirms Mammograms' Benefits 2Health News:Longest Trial Ever Confirms Mammograms' Benefits 3Health News:Researchers at Oregon Health & Science University discover MS-like disease in monkeys 2Health News:Genome Map May Help Save Tasmanian Devils 2
(Date:7/11/2014)... July 11, 2014  Kindred Hospital Houston Northwest, ... the opening of its new outpatient wound healing ... to people with chronic, hard to heal wounds. ... lead to amputation, lower leg wounds related to ... closure, and traumatic injury wounds which are complex ...
(Date:7/11/2014)... York , July 11, 2014 ... Transparency Market Research "Endoscopy Devices Market (Endoscopes, Endoscopic Operative ... Share, Growth, Trends and Forecast, 2013-2019" the global endoscopy ... 2012 and is expected to grow at a CAGR ... estimated value of USD 36.9 billion in 2019. ...
(Date:7/11/2014)... 2014 Show organisers ... Health Expo 2014 were a brand new ... London , plus a 10% ...        (Logo: http://photos.prnewswire.com/prnh/20130723/629764-a) ...      (Photo: http://photos.prnewswire.com/prnh/20140711/696892-b ...
Breaking Medicine Technology:Kindred Hospital Houston Northwest, With Wound Care Specialists, Opens Outpatient Wound Healing And Hyperbaric Center 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 3Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 4Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 5Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 6UK's Flagship Health & Safety Event Has Successful Inaugural Year in London 2UK's Flagship Health & Safety Event Has Successful Inaugural Year in London 3UK's Flagship Health & Safety Event Has Successful Inaugural Year in London 4
... MRI Medical Inc. is changing its name to Xeridiem ... plan. "Although we,re changing our name, we ... superior design, development, and manufacturing services that we,ve provided ... Devices, Inc.,s President. "Our mission remains the same - to ...
... Aerotel Medical Systems , a leading global supplier ... showcase its mobile health (mHealth) and other telemedicine solutions at ... Spain from February 14-17 at Hall 2, booth 2C12. ... healthcare providers around the world to reduce costs and improve ...
Cached Medicine Technology:MRI Medical Inc. Changing Name to Xeridiem Medical Devices, Inc. 2Aerotel to Present Mobile Health and Telemedicine Solutions at Mobile World Congress 2011 2
Comfort Wrist Immobilizer with thumb abduction. 8"L, soft, padded comfort-type wrist immobilizer with dorsal metal stay. The thumb is held in abduction and splintered with a short metal stay....
... Splint immobilizes and positions the elbow at ... less prominent. Restricts full extension and flexion ... and helps prevent pain and irritation due ... and post-cast removal. Rigid, high-density beige polyethylene ...
... is constructed of a durable heat moldable thermoplastic ... tendons of the hand and fingers from stress ... the later stages of the healing process. , ... and positions the wrist at 30° of flexion, ...
Combination Oppenheimer with Knuckle Bender - to dorsiflex wrist and flex MCP joints; includes two attachments to extend/flex distal finger joints....
Medicine Products: