Navigation Links
JCI online early table of contents: April 13, 2009
Date:4/13/2009

EDITOR'S PICK: Enhancing the effects of the drug used to treat chronic myeloid leukemia

Individuals with chronic myeloid leukemia (CML) are first treated with a drug known as imatinib mesylate. Although very effective, as the disease progresses it often becomes resistant to the drug. However, a team of researchers, at the University of Leicester, United Kingdom, and Thomas Jefferson University, Philadelphia, has identified a class of drugs that might enhance the therapeutic effects of imatinib mesylate and other drugs that target the same molecule.

The team, led by Paolo Salomoni and Bruno Calabretta, observed that for several different CML cell lines and primary cells, although imatinib mesylate killed the majority of cells, a marked proportion underwent a process known as autophagy. Consistent with studies indicating that the induction of autophagy can provide a mechanism of cellular survival, suppression of autophagy using either drugs or RNA interference enhanced imatinib mesylateinduced death of CML cell lines, primary CML cells, and CML stem cells. The authors therefore suggest that inhibitors of autophagy might be used with imatinib mesylate or other drugs that target the same molecule to enhance their therapeutic benefits.

AUTHOR CONTACT:
Paolo Salomoni
University of Leicester, Leicester, United Kingdom.
Phone: 44-116-2525568; Fax: 44-116-2525616; E-mail: ps90@le.ac.uk.

Bruno Calabretta
Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Phone: (215) 503-4522; Fax: (215) 923-0249; E-mail: bruno.calabretta@mail.jci.tju.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=35660


NEUROBIOLOGY: A novel zebrafish model for screening drugs for Alzheimer dise
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6

Related medicine news :

1. HIV denialists spread misinformation online -- consequences could be deadly; and more
2. Consequences of online HIV denial; and more
3. Online Epidemic Gives Clues to Bird Flu Spread
4. MedHelp to Add Top Stanford Surgeons and Specialized Forums to Online Health Community
5. Online Celebrity Shoe Charity Auction for Womens Heart Health Opens Bidding
6. Syndicom to Launch Online Community for DePuy Spine
7. Elder Caregiving Site ShirleyBOARD.com Wins WebAward for Outstanding Online Community
8. Peer-Reviewed, Online Database Showcases Local, County and State Pandemic Planning
9. CIGNA Behavioral Health Offers Members Online Provider Profiles
10. Dynamic Energy Systems Goes Online and On-Demand
11. North Shore-LIJ Health System Begins Online Posting of Hospital Infection Rates, Other Performance Information
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... off depression among retirees, particularly among those who live ... The Journals of Gerontology, Series B: Psychological Sciences and ... Use and Depression Among Retired Older Adults in the ... that Internet use reduced the probability of a depressed ... , Late-life depression affects between 5 and 10 million ...
(Date:4/17/2014)... ribbon representing a disease. A pink ribbon is well known ... think of with lung cancer?, Although white has been identified ... black may be the only one they think fits., A ... smokers between the ages of 51 to 79 years old, ... these patients, the emotional toll it can have and how ...
(Date:4/17/2014)... less than 40 years away from a food shortage ... according to a top scientist at the U.S. Agency ... history, food production will be limited on a global ... said Dr. Fred Davies, senior science advisor for the ... as politically destabilizing by 2050 as energy issues are ...
(Date:4/17/2014)... after they suffer a cardiac arrest outside of a ... according to new research conducted at St. Michael,s Hospital. ... cardiac arrest get adrenaline, which has been the drug ... Steve Lin, an emergency physician and trauma team leader ... long-term survival rates of patients who suffer a cardiac ...
(Date:4/17/2014)... LSTM have called for more research to be ... children in sub-Saharan Africa. In a paper in ... Russell Stothard, working with colleagues in the department ... University, in Cleveland Ohio, University of Cambridge and ... into the joint burden of HIV/AIDS and schistosomiasis ...
Breaking Medicine News(10 mins):Health News:Internet use may cut retirees' depression 2Health News:Unraveling the 'black ribbon' around lung cancer 2Health News:Food shortages could be most critical world issue by mid-century 2Health News:Adrenaline does little to increase patient's survival after cardiac arrest 2Health News:More research called for into HIV and schistosomiasis coinfection in African children 2
... By Amanda Gardner HealthDay Reporter , MONDAY, ... Monday detailed a slew of violations that included the ... two Iowa farms implicated in the recent egg recall ... from what should be happening," Michael Taylor, deputy commissioner ...
... greater clarity on the legal implications of testing incapacitated patients ... often done following staff needlestick injuries, in possible breach of ... of Anaesthesia , reports on the results of an ... Northern Ireland. It is accompanied by an editorial by ...
... Mo. As U.S. demographics continue to shift rapidly, the ... promoting diverse points of view within the MU community and ... recipients of $100,000 grants from the Ford Foundation Difficult Dialogues ... number of those original institutions to receive an additional $100,000 ...
... By Steven Reinberg HealthDay Reporter , MONDAY, Aug. ... the United States continues to rise and steps are needed ... 1996 to 2007 the rate of cesarean delivery climbed by ... are now being delivered by cesarean delivery," lead researcher Dr. ...
... with acute coronary syndromes initially treated with the anticoagulant ... angioplasty) and received a lower dose of the anticoagulant ... rate of major bleeding and vascular access site complications, ... September 22 issue of JAMA . The study ...
... landmark international study, coordinated by McMaster University, has ... called unfractionated heparin (UFH) during angioplasty did not ... dose UFH in patients initially treated with a ... the OASIS 5 trial, researchers from McMaster University ...
Cached Medicine News:Health News:FDA Finds Rodents, Manure Piles at Farms in Egg Recall 2Health News:FDA Finds Rodents, Manure Piles at Farms in Egg Recall 3Health News:Hospitals face legal dilemma if they test incapacitated patients after needle accidents 2Health News:Hospitals face legal dilemma if they test incapacitated patients after needle accidents 3Health News:Hospitals face legal dilemma if they test incapacitated patients after needle accidents 4Health News:Difficult Dialogues Initiative promotes diversity at MU, around country 2Health News:Almost 1 in 3 First-Time Deliveries Now Via C-Section 2Health News:Almost 1 in 3 First-Time Deliveries Now Via C-Section 3Health News:Almost 1 in 3 First-Time Deliveries Now Via C-Section 4Health News:Lower-dose heparin use during coronary procedure does not appear to reduce risk of major bleeding 2Health News:Lower-dose heparin use during coronary procedure does not appear to reduce risk of major bleeding 3Health News:Drug trial results refine treatment during angioplasty operations 2Health News:Drug trial results refine treatment during angioplasty operations 3
(Date:1/15/2014)... , Jan. 15, 2014 Reportlinker.com ... report is available in its catalogue: ... and Technologies for Advanced Drug Delivery ... Administration http://www.reportlinker.com/p01941928/Global-Markets-and-Technologies-for-Advanced-Drug-Delivery-Systems----Focus-on-Routes-of-Administration.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Drug_Delivery_Technology ...
(Date:1/14/2014)...  Luminex Corporation (Nasdaq: LMNX ) today announced that ... 2013 on Monday, February 3, 2014. A press release announcing ... trading. (Logo: http://photos.prnewswire.com/prnh/20100104/LUMINEXLOGO ) ... highlights and financial results for the fourth quarter and twelve ...
(Date:1/14/2014)... /PRNewswire-iReach/ -- Acumed,s new SLIC Screw System - a ... to place and insert the screw accurately - offers ... ligament) repair or reconstruction as it holds the bones ... http://photos.prnewswire.com/prnh/20140114/MN45636 ) The SLIC Screw ...
Breaking Medicine Technology:Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 16Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 2Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 3Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 2Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 3
... new recommendation from the U.S. Preventive Services Task Force (USPSTF) ... attacks and strokes among many adults, the head of Partnership ... reduces first heart attacks in men and first strokes in ... of 45 and 79 and to women 55 to 79. ...
... Eastern Time - SOUTH SAN FRANCISCO, Calif., March 16 ... a biopharmaceutical company focused on oncology, today reported financial ... 31, 2008, and provided a corporate update. "During the ... our goal of developing picoplatin as an oncology platform ...
Cached Medicine Technology:New Aspirin Recommendation Can Help Prevent Heart Attacks & Strokes, Says Partnership for Prevention 2Poniard Pharmaceuticals Reports Fourth Quarter and Year End 2008 Financial Results and Provides a Corporate Update 2Poniard Pharmaceuticals Reports Fourth Quarter and Year End 2008 Financial Results and Provides a Corporate Update 3Poniard Pharmaceuticals Reports Fourth Quarter and Year End 2008 Financial Results and Provides a Corporate Update 4Poniard Pharmaceuticals Reports Fourth Quarter and Year End 2008 Financial Results and Provides a Corporate Update 5Poniard Pharmaceuticals Reports Fourth Quarter and Year End 2008 Financial Results and Provides a Corporate Update 6Poniard Pharmaceuticals Reports Fourth Quarter and Year End 2008 Financial Results and Provides a Corporate Update 7Poniard Pharmaceuticals Reports Fourth Quarter and Year End 2008 Financial Results and Provides a Corporate Update 8Poniard Pharmaceuticals Reports Fourth Quarter and Year End 2008 Financial Results and Provides a Corporate Update 9
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: