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JCI online early table of contents: April 11, 2011
Date:4/12/2011

ess, suggesting that this gene also plays a role in the nerve cells of the inner ear, though treatment with CoQ10 did not improve this defect. The researchers hope that by identifying the causitive mutations in NS patients, they may be better able to offer effective medical treatments.

TITLE: COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness

AUTHOR CONTACT:
Friedhelm Hildebrandt
University of Michigan, Ann Arbor, MI, USA
Phone: 1-734-615 7285; Fax: 1-734-615 1386; E-mail: fhilde@med.umich.edu
View this article at: http://www.jci.org/articles/view/45693?key=207094ccdba5f1be3a3a


IMMUNOLOGY Designing better CARs for cancer therapy

One new method of cancer treatment is the delivery of immune cells that have been genetically altered to express receptors that recognize tumor-specific molecules (so-called chimeric antigen receptors, CARs), and thus are directed to attack tumor cells. The addition of co-stimulatory molecules which enhance and sustain the immune response has improved the efficacy of this approach in pre-clinical studies. However, the precise design of CARs has been controversial, and it remains unclear whether they will be effective in human patients.

In new research, Gianpietro Dotti and colleagues, at Baylor College of Medicine in Houston, Texas, directly compared the efficacy of two CAR designs in patients with non-Hodgkin lymphoma. They found that the addition of the co-stimulatory molecule greatly enhanced the immune response, and made it more durable. The researchers hope that this clinical study will have far-reaching implications for the design of this type of immunotherapy.

TITLE: CD28 costimulation improves expansion and persistence of chimeric antigen receptormodified T cells in lymphoma patients

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Contact: Kathryn Claiborn
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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