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JCI online early table of contents: April 11, 2011
Date:4/12/2011

artmouth-Hitchcock Medical Center in Hanover, New Hampshire, investigated how vitiligo affected T cell responses to melanoma in mice. They found that destruction of melanocytes was required for tumor immunity, and further, that the T cells associated with vitiligo provided a lasting protection against tumor growth. The researchers believe that these data show that autoimmune destruction of normal tissues is a beneficial process that occurs as the body fights cancer, and propose that inducing vitiligo in melanoma patients might enhance their natural immune response.

TITLE: Autoimmune melanocyte destruction is required for robust CD8+ memory T cell responses to mouse melanoma

AUTHOR CONTACT:
Mary Jo Turk
Dartmouth Medical School, Lebanon, NH, USA
Phone: 603-653-3549; Fax: 603-653-9952; E-mail: mary.jo.turk@dartmouth.edu
View this article at: http://www.jci.org/articles/view/44849?key=774067605d0986435bf3


IMMUNOLOGY Targeting multiple pathways improves vaccine efficacy

One of the goals of vaccine design is to elicit strong reactions from multiple groups of immune cells, both those that confer an acute response to infection, and those that will provide a lasting immune memory. To achieve this, scientists have begun physically linking molecules that activate responses through different pathways. Researchers have previously immunized mice with proteins coupled to nucleic acids (so-called conjugate vaccines) so that they might stimulate both the adaptive and innate immune responses simultaneously. However, the mechanisms that explain the improved responses to these conjugate vaccines are not completely understood.

In this paper, Bob Seder and collaborators at the National Institutes of Health in Bethesda, Maryland, found that conjugating proteins to nucleic acids increased the
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Contact: Kathryn Claiborn
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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