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JCI online early table of contents: April 11, 2011
Date:4/12/2011

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In new research, Dontscho Kerjaschki and colleagues, of the Medical University of Vienna in Austria studied samples from human breast cancer patients, and found that in order to move into new lymph nodes, tumors cells first invade the lymphatic vessels that connect them. They further found evidence in model systems that this invasion requires that tumor cells generate an enzyme called 15-lipoxygenase. The researchers believe that this work suggests that inhibition of 15-lipoxygenase and related enzymes might be an effective strategy to prevent tumor spread.

TITLE: Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse

AUTHOR CONTACT:
Dontscho Kerjaschki
Medical University Vienna, A-1090 Vienna, AUSTRIA
Phone: +43-1-40400-5176; Fax: +43-1-40400-5193; E-mail: dontscho.kerjaschki@meduniwien.ac.at
View this article at: http://www.jci.org/articles/view/44751?key=d597507d4135d2004e46


ONCOLOGY Autoimmune reaction could help fight melanoma

One potential approach to fighting cancer involves directing the T cells of the immune system to recognize molecules produced by tumor cells (antigens) and then attack those cells, a method called immunotherapy. However, the antigens produced by tumor cells may be identical to molecules produced by non-cancerous cells, and T cell recognition of these can result in an undesirable autoimmune attack. A naturally-occurring example of this is melanoma-associated vitiligo, in which immune cells directed against a skin cancer lesion also attack healthy melanocytes, resulting destruction of those cells and patches of skin that lack normal pigmentation.

In this paper, Mary Jo Turk and colleagues, of Dartmouth Medical School and the D
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Contact: Kathryn Claiborn
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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