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JCI online early table of contents: April 11, 2011
Date:4/12/2011

re-existing thyroid gland disorders could help improve the outcome of individuals who suffer from multiple diseases. Increased levels of cell signaling molecules called cytokines, particularly Interleukin-6 (IL-6), are also associated with NTIS, but how these contribute to changes in T3 levels is not understood.

In this paper, Ana Maia and colleagues, of the Universidade Federal do Rio Grande do Sul, in Porto Alegre, Brazil, examined the effect of IL-6 on the enzymes that process T3. They found that IL-6 suppressed the action of the enzymes that generate T3, and promoted the action of the enzyme that deactivates T3. In addition, the effect of IL-6 could be inhibited by antioxidants. The researchers believe that these results suggest that a state of oxidative stress, common to many acute and chronic illnesses, may underlie the activation of IL-6 and initiation of NTIS.

TITLE: IL-6 promotes nonthyroidal illness syndrome by blocking thyroxine activation while promoting thyroid hormone inactivation in human cells

AUTHOR CONTACT:
Ana Luiza Maia
Universidade Federal do Rio Grande do Sul, Porto Alegre, BRAZIL
Phone: 55-51-33598127; Fax: 55-51-33325188; E-mail: almaia@ufrgs.br
View this article at: http://www.jci.org/articles/view/44678?key=b51ab7b2bc4b4dc1b247


ONCOLOGY Research identifies pathway involved in breast cancer metastasis

In breast cancer, lymph node metastasis is a common occurrence, and the progression of the cancer in this way is a reliable predictor of patient survival. These metastases occur first in the lymph node close to the breast called the sentinel, and then progressively move to new lymph nodes. The mechanisms that control this movement of tumor cells are not well understood, but could represent novel targets to impede the progression of metastatic cance
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Contact: Kathryn Claiborn
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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