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JCI online early table of contents: April 11, 2011
Date:4/12/2011

EDITOR'S PICK Protein could improve recovery from heart attacks

Angiogenesis, the development of new blood vessels, is required during embryonic development and wound healing, as well as during disease processes such as tumor growth. The signals that direct angiogensis are incompletely understood, but could represent novel targets for the development of therapies that promote or inhibit this process.

In this paper, Young-Guen Kwon and colleagues, of Yonsei University in Seoul, Korea, investigated the role of two related proteins- DKK1 and DKK2- in angiogenesis. These proteins are known to have similar functions in inhibiting a particular cell signaling pathway, but Kwon and colleagues found that they played opposite roles in directing angiogenesis. Remarkably, they discovered that injection of DKK2 improved vascular regeneration in a mouse model of myocardial infarction (heart attack). The researchers are hopeful that pharmacological manipulation of DKK1 and DKK2 could be used to treat various vascular diseases.

TITLE: The WNT antagonist Dickkopf2 promotes angiogenesis in rodent and human endothelial cells

AUTHOR CONTACT:
Young-Guen Kwon
Yonsei University, Seoul, KOR
Phone: 82-2-2123-5697; Fax: ; E-mail: ygkwon@yonsei.ac.kr
View this article at: http://www.jci.org/articles/view/42556?key=b7440cf00827bc4f983f


METABOLISM Mouse model reveals multiple roads to control blood sugar

Diabetes is a disease of uncontrolled blood sugar levels that results from absolute or relative insufficiency of the hormone insulin. Other hormones contribute to the regulation of blood sugar control and insulin release, and can also be dysregulated in diabetic patients. One of these is glucagon; diabetic patients display disordered glucagon signaling, and drugs that inh
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Contact: Kathryn Claiborn
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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