Navigation Links
JCI online ahead of print table of contents for May 8, 2014
Date:5/8/2014

hanced blood brain barrier (BBB) permeability. There is a strong sex bias in MS patients, with 3 to 4 female patients for every affected male. The female bias is recapitulated in SLJ mice with experimental autoimmune encephalitis (EAE), a commonly used MS model. In this issue of the Journal of Clinical Investigation, Robyn Klein and colleagues at Washington University performed whole transcriptome analysis of transcripts collected from EAE-susceptible CNS regions in nave SJL mice and determined that female SJL mice express dramatically higher levels of the sphingosine-1 phosphate receptor S1PR2 compared to male animals. Expression and activity of S1PR2 were associated with endothelial barrier dysfunction, which enhanced BBB permeability and the loss of immune privilege. Pharmacological inactivation of S1PR2 signaling attenuated BBB permeability and EAE severity. Importantly, female MS patients also exhibited increased expression of S1PR2 in the CNS vasculature during periods of MS-associated CNS autoimmunity, indicating that S1PR2 may be a suitable therapeutic target in humans.

TITLE: Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility

AUTHOR CONTACT: Robyn S. Klein Washington University, Saint Louis, MO, USA Phone: 314 286 2140; E-mail: rklein@dom.wustl.edu

View this article at: http://www.jci.org/articles/view/73408


IMMUNOLOGY

TITLE: Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells

AUTHOR CONTACT: David A. Hafler Yale School of Medicine, New Haven, CT, USA Phone: 2037856351; E-mail: david.hafler@yale.edu

Or

David M. Kofler Yale School of Medicine, New Haven, CT, USA
'/>"/>

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. New online portal, app provide information on tsunami zones in the Northwest
2. Being Ignored Feels Just as Bad Online
3. Online Tool Could Diagnose Autism Quickly, Developers Say
4. Online Dating Scams Can Take Emotional, Financial Toll
5. Annals of Internal Medicine tip sheet for May 8, 2012, online issue
6. Data release from the Allen Institute for Brain Science expands online atlas offerings
7. Vendors in Nevada, Michigan, & Illinois to be Featured on the PartyPOP.com Online Network
8. Annals of Internal Medicine tip sheet for June 19, 2012, online issue
9. Online weight loss programs that feature successful dieters may help
10. DotComSecrets’ Russell Brunson Is Revealing Online Money Making Secrets in Free Webinars for Students
11. DermaShoppe.com Celebrates Its Second Successful Year in Online Skin Care
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... Angeles, California (PRWEB) October 22, 2014 Hay ... 2.0: Move Beyond Addiction and Upgrade Your Life (Paperback; $10.82) ... field of Yoga & Recovery. This book is meant ... thrive in a life of recovery. , Recovery 2.0 ... the 12 Steps; Recovery 2.0 is a guide for what ...
(Date:10/22/2014)... October 22, 2014 Losing Weight Your Body’s ... is staring you in the face, it certainly can be ... do your body an extra favor by doing it the ... crash diets. Instead, listen to your body, exercise regularly, and ... is essential to losing weight; you need to exercise more ...
(Date:10/22/2014)... By Steven Reinberg ... -- Infants who quickly add weight and length may be ... study suggests. In adults, certain genes have been linked ... promote proportionate gains in fat and lean muscle, the researchers ... be heavier and taller. By ages 2 and 3, however, ...
(Date:10/22/2014)... TUESDAY, Oct. 21, 2014 (HealthDay News) -- Measures taken ... plantation in Ebola-ravaged Liberia may have limited the spread ... researchers report. The Firestone Natural Rubber Co. provides ... and residents of nearby densely populated communities. Between ... and suspected Ebola cases among those 80,000 people. That ...
(Date:10/20/2014)... Allegheny General Hospital’s (AGH) Cardiovascular Institute is offering ... a damaged mitral valve as the heart continues to ... Abbott Vascular , is designed to treat degenerative ... which the heart’s mitral valve leaflets fail to close ... left ventricle into the left atrium. The heart must ...
Breaking Medicine News(10 mins):Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 2Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 3Health News:ReductionGuruMD Presents Ways to Improve Your Weight Loss Results 2Health News:Tall, Heavy 1-Year-Olds May Be at Risk for Obesity Later, Study Finds 2Health News:Tire Company Sets Standard for Ebola Care in Liberia: CDC 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 3
... Pioneer Surgical Technology, Inc., a leading innovator in the ... has named Thomas J. McLeer as its new Chief Marketing ... 2009. , , Mr. McLeer, who had been Vice ... in charge of managing and directing all of Pioneer,s spinal ...
... Uganda was the first country in sub-Saharan Africa to register ... however, remains serious as approximately one million Ugandans are HIV ... cost and powerful weapon against new HIV infections: voluntary medical ... and South Africa have demonstrated that male circumcision reduces the ...
... , HARRISBURG, Pa., July 10 Hunters will see similar ... of which open Sept. 1, as part of Pennsylvania,s 2009-10 ... Director Carl G. Roe. , , Dove hunters, once ... season. During the first season (Sept. 1-26), hunting will start ...
... J. Raab, M.D., head of Dermatology & Cosmetic Skin Surgery, ... filler for the correction of smile lines, to treat patients ... Raab has treated over 150 patients with Artefill the past ... the correction of wrinkles. , , "Artefill is ...
... Today, Earvin "Magic" Johnson, Chairman and Founder of ... annual Taylor Michaels Scholarship Program Life Skills Leadership Conference ... 150 deserving scholarship students attending. They come from all ... to educate, entertain and empower. The Taylor Michaels Scholarship ...
... July 10 Sysmex America, Inc., a leading ... today announced the appointment of Jim Cusack as ... Ralph Taylor, Vice President of Marketing & Medical ... key role in managing the company,s existing business ...
Cached Medicine News:Health News:Pioneer Surgical Technology, Inc. Names Thomas J. McLeer as Chief Marketing Officer and General Manager of Spinal Operations 2Health News:Ugandan Medical Male Circumcision Program Launched to Prevent HIV Transmission 2Health News:Dove and Early Canada Goose Seasons to Begin Sept. 1; Game Commission Posts Avian Influenza Information on Website 2Health News:Dove and Early Canada Goose Seasons to Begin Sept. 1; Game Commission Posts Avian Influenza Information on Website 3Health News:Dove and Early Canada Goose Seasons to Begin Sept. 1; Game Commission Posts Avian Influenza Information on Website 4Health News:Dove and Early Canada Goose Seasons to Begin Sept. 1; Game Commission Posts Avian Influenza Information on Website 5Health News:Dove and Early Canada Goose Seasons to Begin Sept. 1; Game Commission Posts Avian Influenza Information on Website 6Health News:Dove and Early Canada Goose Seasons to Begin Sept. 1; Game Commission Posts Avian Influenza Information on Website 7Health News:Dr. Benjamin Raab of Naperville, IL Selects Artefill to Meet Growing Patient Demand for a Longer Lasting Dermal Filler 2Health News:Dr. Benjamin Raab of Naperville, IL Selects Artefill to Meet Growing Patient Demand for a Longer Lasting Dermal Filler 3Health News:Earvin 'Magic' Johnson and the Magic Johnson Foundation Give Students their 'Blueprint for Success' at Annual Leadership Conference 2Health News:Sysmex America Names Industry Veteran to Business Development Post 2
(Date:10/22/2014)... Investor-Edge has initiated coverage on the following ... Progenics Pharmaceuticals Inc. (NASDAQ: PGNX ), Threshold ... Inc. (NASDAQ: IDRA ), and Merrimack Pharmaceuticals ... can be accessed at: http://investor-edge.com/register . ... at 4,419.48, up 2.40%, the Dow Jones Industrial Average ...
(Date:10/22/2014)... RPh, of Vernak Farms Pharmacy in Skaneateles, ... Roentsch Scholarship by the Professional Compounding Centers of America ... during PCCA,s International Seminar, held October 8-10, ... pharmacist and PCCA member who embodies the innovative and ... pharmacist in the compounding community. George ...
(Date:10/22/2014)... , Oct. 22, 2014 Moms are ... health trackers for themselves and their kids, according to ... Report: Health & Fitness Go Mobile for Moms, the ... Series. BabyCenter, the number 1 pregnancy and parenting web ... that 55 percent of moms surveyed say they can,t ...
Breaking Medicine Technology:Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 2Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 3Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 4Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 5PCCA Awards Charlene Vernak, RPh, the George Roentsch Scholarship 2BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 2BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 3BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 4
... 12 Alfacell Corporation,(Nasdaq: ACEL ) today ... deaths) have occurred in the Phase IIIb clinical ... of patients with unresectable,malignant mesothelioma. The number of ... total events in the study had reached 316. ...
... Simultaneously Identify Staphylococcus Aureus and Methicillin-Resistant ... 11 BD Diagnostics, a segment,of BD (Becton, Dickinson ... it,has made a 510(k) submission to the U.S. Food ... GeneOhmTM StaphSR assay. This will,be the first assay for ...
Cached Medicine Technology:Alfacell Updates Status of ONCONASE(R) Phase III Clinical Program 2Alfacell Updates Status of ONCONASE(R) Phase III Clinical Program 3BD Announces FDA 510(K) Submission of Rapid Molecular Test to Identify Patients Carrying Staph Superbug Prior to Surgery 2BD Announces FDA 510(K) Submission of Rapid Molecular Test to Identify Patients Carrying Staph Superbug Prior to Surgery 3
... Bird and Cronin, ... manufacturer of Patient Footwear, ... Patient Care Products. Our ... highest quality and available ...
... PneumaticWalker incorporates a unique combination of support, ... helps support the limb and provides full-shell ... plantar pressures. Lining the shell are four ... The aircells can be custom inflated using ...
... cost-effective walking brace that provides full-shell protection ... durable, semi-rigid shell that supports the limb ... helps reduce plantar pressures. Housed within the ... support at the malleoli. Each aircell can ...
... This Sarmiento style Patella-Tendon-Bearing brace is designed ... the tibia and fibula. The tibial crest ... intra medullary nailing and removal of internal ... movement of joints above and below the ...
Medicine Products: