Navigation Links
JCI online ahead of print table of contents for May 8, 2014

Leptin-dependent regulation of reproduction

Individuals that lack the adipose-derived hormone leptin fail to complete puberty and are infertile. Leptin-deficient mice recapitulate human phenotypes; however, it is not clear how leptin and leptin signaling impact the reproductive axis. In this issue of the Journal of Clinical Investigation, Vincent Prevot and colleagues at INSERM U837 evaluated leptin deficient animals and determined that leptin acts directly on neurons in the preoptic region of the hypothalamus that synthesize nitric oxide to regulate peripheral levels of leutinizing hormone (LH), which is essential for reproduction. Administration of leptin increased neuronal production of nitric oxide synthase, while deletion or pharmacological inhibition of NOS blocked leptin-induced LH release in mice. Mathematical models indicated that leptin action in the preoptic region leads to a build-up of NO that reaches a level that is critical for the induction and release of gonadotropin-releasing hormone (GnRH) and subsequent LH secretion by the pituitary gland. This study demonstrates that leptin communicates the status of peripheral energy stores to GnRH-releasing neurons via the preoptic hypothalamus to regulate fertility.

TITLE: Leptin-dependent neuronal NO signaling in the preoptic hypothalamus facilitates reproduction

AUTHOR CONTACT: Vincent Prevot Inserm U837, Lille, FRA Phone: +33 612-90-38-76; E-mail:

View this article at:

Female susceptibility to CNS autoimmunity linked to sphingosine-1 phosphate receptor

Relapsing-remitting multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) that is defined by extensive neuronal demyelination and enhanced blood brain barrier (BBB) permeability. There is a strong sex bias in MS patients, with 3 to 4 female patients for every affected male. The female bias is recapitulated in SLJ mice with experimental autoimmune encephalitis (EAE), a commonly used MS model. In this issue of the Journal of Clinical Investigation, Robyn Klein and colleagues at Washington University performed whole transcriptome analysis of transcripts collected from EAE-susceptible CNS regions in nave SJL mice and determined that female SJL mice express dramatically higher levels of the sphingosine-1 phosphate receptor S1PR2 compared to male animals. Expression and activity of S1PR2 were associated with endothelial barrier dysfunction, which enhanced BBB permeability and the loss of immune privilege. Pharmacological inactivation of S1PR2 signaling attenuated BBB permeability and EAE severity. Importantly, female MS patients also exhibited increased expression of S1PR2 in the CNS vasculature during periods of MS-associated CNS autoimmunity, indicating that S1PR2 may be a suitable therapeutic target in humans.

TITLE: Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility

AUTHOR CONTACT: Robyn S. Klein Washington University, Saint Louis, MO, USA Phone: 314 286 2140; E-mail:

View this article at:


TITLE: Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells

AUTHOR CONTACT: David A. Hafler Yale School of Medicine, New Haven, CT, USA Phone: 2037856351; E-mail:


David M. Kofler Yale School of Medicine, New Haven, CT, USA Phone: 203.785.5947; Fax: 203.785.2238; E-mail:

View this article at:


TITLE: Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction

AUTHOR CONTACT: Thorsten Mempel Massachusetts General Hospital & Harvard Medical School, Charlestown, MA, USA Phone: 617-724-4596; E-mail:

View this article at:

TITLE Inhibition of ER stressassociated IRE-1/XBP-1 pathway reduces leukemic cell survival

AUTHOR CONTACT: Chih-Chi Andrew Hu H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA Phone: 813-745-4167; E-mail:


Juan R. Del Valle H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA Phone: 813.745.4167; Fax: 813.745.1328; Email:

View this article at:

TITLE: Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm

AUTHOR CONTACT: Jing Zhang University of Wisconsin School of Medicine and Public Health, Madison, WI, USA Phone: 608-263-1147; E-mail:

View this article at:


TITLE: KLF4-dependent epigenetic remodeling modulates podocyte phenotypes and attenuates proteinuria

AUTHOR CONTACT: Hiroyuki Sasamura Keio University, Tokyo, JPN Phone: 81-3-5363-3796; Fax: 81-3-3359-2745; E-mail:

View this article at:


TITLE: Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1induced pruritus

AUTHOR CONTACT: Martin Steinhoff UCD (University College Dublin), Dublin, IRL Phone: +353 1 716 6261; Fax: +353 1 716 6265; E-mail:

View this article at:


Contact: Corinne Williams
Journal of Clinical Investigation

Related medicine news :

1. New online portal, app provide information on tsunami zones in the Northwest
2. Being Ignored Feels Just as Bad Online
3. Online Tool Could Diagnose Autism Quickly, Developers Say
4. Online Dating Scams Can Take Emotional, Financial Toll
5. Annals of Internal Medicine tip sheet for May 8, 2012, online issue
6. Data release from the Allen Institute for Brain Science expands online atlas offerings
7. Vendors in Nevada, Michigan, & Illinois to be Featured on the Online Network
8. Annals of Internal Medicine tip sheet for June 19, 2012, online issue
9. Online weight loss programs that feature successful dieters may help
10. DotComSecrets’ Russell Brunson Is Revealing Online Money Making Secrets in Free Webinars for Students
11. Celebrates Its Second Successful Year in Online Skin Care
Post Your Comments:
(Date:11/25/2015)... ... 2015 , ... The holiday season is jam-packed with family ... of attendees is of the utmost importance. Whether you are cooking at home ... recipes a try this holiday season. , Turkey Croquettes ,     Ingredients: ...
(Date:11/25/2015)... ... November 25, 2015 , ... Medical ... once again for its stellar workplace culture with the company’s Cincinnati office being ... Medical Solutions’ Cincinnati office was named a finalist in Cincinnati Business Courier’s 13th ...
(Date:11/25/2015)... (PRWEB) , ... November 25, 2015 , ... Dr. John ... to learn more about hair loss treatment with the Capillus272™ Pro laser therapy cap. ... solution for thicker and fuller hair, without the need for surgery, prescription pills, or ...
(Date:11/25/2015)... ... November 25, 2015 , ... On November 10, 2015, Bohrer ... Court of Connecticut on behalf of a home health care worker who provided companionship ... former home health care workers employed by Humana, Inc., Humana at Home, Inc., and ...
(Date:11/25/2015)... (PRWEB) , ... November 25, 2015 , ... According to ... surgical robot is being more and more widely heralded as a breakthrough for performing ... Vinci method has over traditional laparoscopic surgery is that it can greatly reduce the ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... 25, 2015 Allergan plc (NYSE: ... Rugen Therapeutics, a start-up  biotechnology company focused on ... disorders and funded by the F-Prime Biomedical Research ... into an exclusive collaboration to support the discovery ... Disorders (ASD) and Obsessive Compulsive disorders (OCD). ...
(Date:11/25/2015)... 2015 USP 800 applies to all ... pharmacists, pharmacy technicians, nurses, physicians, physician assistants, home ... also covers all entities which store, prepare, transport, ... healthcare institutions, patient treatment clinics, physicians, practice facilities, ... --> What is the purpose of ...
(Date:11/25/2015)... 2015 Asia -based ... BioLight and the New Investors will make a direct ... a private placement. The financing will help IOPtima to ... used in the treatment of glaucoma, as well as ... IOPtimate™ system with the U.S. Food and Drug Administration, ...
Breaking Medicine Technology: