Navigation Links
JCI online ahead of print table of contents for May 8, 2014
Date:5/8/2014

Leptin-dependent regulation of reproduction

Individuals that lack the adipose-derived hormone leptin fail to complete puberty and are infertile. Leptin-deficient mice recapitulate human phenotypes; however, it is not clear how leptin and leptin signaling impact the reproductive axis. In this issue of the Journal of Clinical Investigation, Vincent Prevot and colleagues at INSERM U837 evaluated leptin deficient animals and determined that leptin acts directly on neurons in the preoptic region of the hypothalamus that synthesize nitric oxide to regulate peripheral levels of leutinizing hormone (LH), which is essential for reproduction. Administration of leptin increased neuronal production of nitric oxide synthase, while deletion or pharmacological inhibition of NOS blocked leptin-induced LH release in mice. Mathematical models indicated that leptin action in the preoptic region leads to a build-up of NO that reaches a level that is critical for the induction and release of gonadotropin-releasing hormone (GnRH) and subsequent LH secretion by the pituitary gland. This study demonstrates that leptin communicates the status of peripheral energy stores to GnRH-releasing neurons via the preoptic hypothalamus to regulate fertility.

TITLE: Leptin-dependent neuronal NO signaling in the preoptic hypothalamus facilitates reproduction

AUTHOR CONTACT: Vincent Prevot Inserm U837, Lille, FRA Phone: +33 612-90-38-76; E-mail: vincent.prevot@inserm.fr

View this article at: http://www.jci.org/articles/view/65928


Female susceptibility to CNS autoimmunity linked to sphingosine-1 phosphate receptor

Relapsing-remitting multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) that is defined by extensive neuronal demyelination and enhanced blood brain barrier (BBB) permeability. There is a strong sex bias in MS patients, with 3 to 4 female patients for every affected male. The female bias is recapitulated in SLJ mice with experimental autoimmune encephalitis (EAE), a commonly used MS model. In this issue of the Journal of Clinical Investigation, Robyn Klein and colleagues at Washington University performed whole transcriptome analysis of transcripts collected from EAE-susceptible CNS regions in nave SJL mice and determined that female SJL mice express dramatically higher levels of the sphingosine-1 phosphate receptor S1PR2 compared to male animals. Expression and activity of S1PR2 were associated with endothelial barrier dysfunction, which enhanced BBB permeability and the loss of immune privilege. Pharmacological inactivation of S1PR2 signaling attenuated BBB permeability and EAE severity. Importantly, female MS patients also exhibited increased expression of S1PR2 in the CNS vasculature during periods of MS-associated CNS autoimmunity, indicating that S1PR2 may be a suitable therapeutic target in humans.

TITLE: Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility

AUTHOR CONTACT: Robyn S. Klein Washington University, Saint Louis, MO, USA Phone: 314 286 2140; E-mail: rklein@dom.wustl.edu

View this article at: http://www.jci.org/articles/view/73408


IMMUNOLOGY

TITLE: Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells

AUTHOR CONTACT: David A. Hafler Yale School of Medicine, New Haven, CT, USA Phone: 2037856351; E-mail: david.hafler@yale.edu

Or

David M. Kofler Yale School of Medicine, New Haven, CT, USA Phone: 203.785.5947; Fax: 203.785.2238; E-mail: david.kofler@yale.edu

View this article at: http://www.jci.org/articles/view/72973

ONCOLOGY

TITLE: Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction

AUTHOR CONTACT: Thorsten Mempel Massachusetts General Hospital & Harvard Medical School, Charlestown, MA, USA Phone: 617-724-4596; E-mail: tmempel@mgh.harvard.edu

View this article at: http://www.jci.org/articles/view/66375

TITLE Inhibition of ER stressassociated IRE-1/XBP-1 pathway reduces leukemic cell survival

AUTHOR CONTACT: Chih-Chi Andrew Hu H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA Phone: 813-745-4167; E-mail: chih-chi.hu@moffitt.org

Or

Juan R. Del Valle H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA Phone: 813.745.4167; Fax: 813.745.1328; Email: Juan.DelValle@moffitt.org

View this article at: http://www.jci.org/articles/view/73448

TITLE: Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm

AUTHOR CONTACT: Jing Zhang University of Wisconsin School of Medicine and Public Health, Madison, WI, USA Phone: 608-263-1147; E-mail: zhang@oncology.wisc.edu

View this article at: http://www.jci.org/articles/view/74182

NEPHROLOGY

TITLE: KLF4-dependent epigenetic remodeling modulates podocyte phenotypes and attenuates proteinuria

AUTHOR CONTACT: Hiroyuki Sasamura Keio University, Tokyo, JPN Phone: 81-3-5363-3796; Fax: 81-3-3359-2745; E-mail: sasamura@a8.keio.jp

View this article at: http://www.jci.org/articles/view/69557

NEUROSCIENCE

TITLE: Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1induced pruritus

AUTHOR CONTACT: Martin Steinhoff UCD (University College Dublin), Dublin, IRL Phone: +353 1 716 6261; Fax: +353 1 716 6265; E-mail: Martin.Steinhoff@ucd.ie

View this article at: http://www.jci.org/articles/view/67323


'/>"/>

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Related medicine news :

1. New online portal, app provide information on tsunami zones in the Northwest
2. Being Ignored Feels Just as Bad Online
3. Online Tool Could Diagnose Autism Quickly, Developers Say
4. Online Dating Scams Can Take Emotional, Financial Toll
5. Annals of Internal Medicine tip sheet for May 8, 2012, online issue
6. Data release from the Allen Institute for Brain Science expands online atlas offerings
7. Vendors in Nevada, Michigan, & Illinois to be Featured on the PartyPOP.com Online Network
8. Annals of Internal Medicine tip sheet for June 19, 2012, online issue
9. Online weight loss programs that feature successful dieters may help
10. DotComSecrets’ Russell Brunson Is Revealing Online Money Making Secrets in Free Webinars for Students
11. DermaShoppe.com Celebrates Its Second Successful Year in Online Skin Care
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2017)... ... August 22, 2017 , ... “Glimpses Of Light”: is a unique ... Of Light” is the creation of published author, J.M. Shepherd, a writer, teacher, traveler, ... to life’s perplexing mysteries. , Shepherd shares, “Love is one of the least understood ...
(Date:8/21/2017)... St. Louis, MO (PRWEB) , ... August 22, 2017 , ... ... and career fairs to help healthcare employers connect with physicians and advanced practitioners like ... of virtual career fairs in August through November of this year. The ...
(Date:8/21/2017)... ... 21, 2017 , ... SportsEngine, Inc. , a division ... Partner of North Country Region Volleyball and will power registration, scheduling, and competition ... providing sport management software to their member clubs. , SportsEngine provides ...
(Date:8/21/2017)... ... ... PIXACORE , an independent full-service agency with a decade of experience ... year by MM&M. , This is the first time PIXACORE has made the Top ... PIXACORE’s newfound recognition reflects its steady trajectory of growth and recent strategic transformation. ...
(Date:8/20/2017)... ... ... total solar eclipse will occur across the U.S. on Monday, August 21, causing ... sun and Earth. This rare event will be magnificent to witness, but what does it ... the road during the total eclipse of the sun. , 1. Plan ahead. The eclipse’s ...
Breaking Medicine News(10 mins):
(Date:8/17/2017)... Laboratories, LLC Chief Science Officer, Dr. Adam Elhofy , will be ... Cell-Ess® Universal Titer Boost at the 9 th annual ... The Bioprocessing Summit convenes more than 1,000 international bioprocess professionals to share ... Cell-Ess ... Cell-Ess is the world,s ...
(Date:8/15/2017)... Aug. 15, 2017 Diplomat Pharmacy, Inc. (NYSE: ... Michigan residents. Naloxone is ... retail pharmacy, G-3320 Beecher Road. ... Food and Drug Administration, is intended to block or ... breathing, and loss of consciousness. The medication is often ...
(Date:8/15/2017)... N.C. , Aug. 15, 2017 AccuGenomics, ... NC , today announced that the company has ... the University of North Carolina at Chapel Hill and ... is designed to characterize and quantify HIV reservoir and ... after pharmacological intervention. The HIV Cure Center is a ...
Breaking Medicine Technology: