Navigation Links
JCI online ahead of print table of contents for May 8, 2014
Date:5/8/2014

Leptin-dependent regulation of reproduction

Individuals that lack the adipose-derived hormone leptin fail to complete puberty and are infertile. Leptin-deficient mice recapitulate human phenotypes; however, it is not clear how leptin and leptin signaling impact the reproductive axis. In this issue of the Journal of Clinical Investigation, Vincent Prevot and colleagues at INSERM U837 evaluated leptin deficient animals and determined that leptin acts directly on neurons in the preoptic region of the hypothalamus that synthesize nitric oxide to regulate peripheral levels of leutinizing hormone (LH), which is essential for reproduction. Administration of leptin increased neuronal production of nitric oxide synthase, while deletion or pharmacological inhibition of NOS blocked leptin-induced LH release in mice. Mathematical models indicated that leptin action in the preoptic region leads to a build-up of NO that reaches a level that is critical for the induction and release of gonadotropin-releasing hormone (GnRH) and subsequent LH secretion by the pituitary gland. This study demonstrates that leptin communicates the status of peripheral energy stores to GnRH-releasing neurons via the preoptic hypothalamus to regulate fertility.

TITLE: Leptin-dependent neuronal NO signaling in the preoptic hypothalamus facilitates reproduction

AUTHOR CONTACT: Vincent Prevot Inserm U837, Lille, FRA Phone: +33 612-90-38-76; E-mail: vincent.prevot@inserm.fr

View this article at: http://www.jci.org/articles/view/65928


Female susceptibility to CNS autoimmunity linked to sphingosine-1 phosphate receptor

Relapsing-remitting multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) that is defined by extensive neuronal demyelination and enhanced blood brain barrier (BBB) permeability. There is a strong sex bias in MS patients, with 3 to 4 female patients for every affected male. The female bias is recapitulated in SLJ mice with experimental autoimmune encephalitis (EAE), a commonly used MS model. In this issue of the Journal of Clinical Investigation, Robyn Klein and colleagues at Washington University performed whole transcriptome analysis of transcripts collected from EAE-susceptible CNS regions in nave SJL mice and determined that female SJL mice express dramatically higher levels of the sphingosine-1 phosphate receptor S1PR2 compared to male animals. Expression and activity of S1PR2 were associated with endothelial barrier dysfunction, which enhanced BBB permeability and the loss of immune privilege. Pharmacological inactivation of S1PR2 signaling attenuated BBB permeability and EAE severity. Importantly, female MS patients also exhibited increased expression of S1PR2 in the CNS vasculature during periods of MS-associated CNS autoimmunity, indicating that S1PR2 may be a suitable therapeutic target in humans.

TITLE: Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility

AUTHOR CONTACT: Robyn S. Klein Washington University, Saint Louis, MO, USA Phone: 314 286 2140; E-mail: rklein@dom.wustl.edu

View this article at: http://www.jci.org/articles/view/73408


IMMUNOLOGY

TITLE: Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells

AUTHOR CONTACT: David A. Hafler Yale School of Medicine, New Haven, CT, USA Phone: 2037856351; E-mail: david.hafler@yale.edu

Or

David M. Kofler Yale School of Medicine, New Haven, CT, USA Phone: 203.785.5947; Fax: 203.785.2238; E-mail: david.kofler@yale.edu

View this article at: http://www.jci.org/articles/view/72973

ONCOLOGY

TITLE: Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction

AUTHOR CONTACT: Thorsten Mempel Massachusetts General Hospital & Harvard Medical School, Charlestown, MA, USA Phone: 617-724-4596; E-mail: tmempel@mgh.harvard.edu

View this article at: http://www.jci.org/articles/view/66375

TITLE Inhibition of ER stressassociated IRE-1/XBP-1 pathway reduces leukemic cell survival

AUTHOR CONTACT: Chih-Chi Andrew Hu H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA Phone: 813-745-4167; E-mail: chih-chi.hu@moffitt.org

Or

Juan R. Del Valle H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA Phone: 813.745.4167; Fax: 813.745.1328; Email: Juan.DelValle@moffitt.org

View this article at: http://www.jci.org/articles/view/73448

TITLE: Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm

AUTHOR CONTACT: Jing Zhang University of Wisconsin School of Medicine and Public Health, Madison, WI, USA Phone: 608-263-1147; E-mail: zhang@oncology.wisc.edu

View this article at: http://www.jci.org/articles/view/74182

NEPHROLOGY

TITLE: KLF4-dependent epigenetic remodeling modulates podocyte phenotypes and attenuates proteinuria

AUTHOR CONTACT: Hiroyuki Sasamura Keio University, Tokyo, JPN Phone: 81-3-5363-3796; Fax: 81-3-3359-2745; E-mail: sasamura@a8.keio.jp

View this article at: http://www.jci.org/articles/view/69557

NEUROSCIENCE

TITLE: Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1induced pruritus

AUTHOR CONTACT: Martin Steinhoff UCD (University College Dublin), Dublin, IRL Phone: +353 1 716 6261; Fax: +353 1 716 6265; E-mail: Martin.Steinhoff@ucd.ie

View this article at: http://www.jci.org/articles/view/67323


'/>"/>

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Related medicine news :

1. New online portal, app provide information on tsunami zones in the Northwest
2. Being Ignored Feels Just as Bad Online
3. Online Tool Could Diagnose Autism Quickly, Developers Say
4. Online Dating Scams Can Take Emotional, Financial Toll
5. Annals of Internal Medicine tip sheet for May 8, 2012, online issue
6. Data release from the Allen Institute for Brain Science expands online atlas offerings
7. Vendors in Nevada, Michigan, & Illinois to be Featured on the PartyPOP.com Online Network
8. Annals of Internal Medicine tip sheet for June 19, 2012, online issue
9. Online weight loss programs that feature successful dieters may help
10. DotComSecrets’ Russell Brunson Is Revealing Online Money Making Secrets in Free Webinars for Students
11. DermaShoppe.com Celebrates Its Second Successful Year in Online Skin Care
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ... June 23, 2017 , ... Moore Insurance, an eastern ... access to asset protection and financial planning services, is teaming up with the ... lives of children with cancer and other chronic diseases. , The For A ...
(Date:6/22/2017)... IN (PRWEB) , ... June 22, 2017 , ... ... benefits advisory organization, is pleased to welcome Whipple & Company as its newest ... the clear purpose of balancing their clients’ risk while tailoring optimized benefit packages ...
(Date:6/22/2017)... ... June 23, 2017 , ... Despite its pervasiveness, many physicians ... available that integrate basic science with clinical practice. Now, however, a timely review has ... clinicians with insight into the etiology of NeuP and educating preclinical scientists on its ...
(Date:6/22/2017)... ... 22, 2017 , ... A June 12 article in The Star ... apparent lack of oral hygiene by an aged parent who had recently suffered a ... a number of steps, including scheduling a dentist visit. Northridge Dental Works, a Los ...
(Date:6/20/2017)... ... June 20, 2017 , ... ... a Texas-based health system, will present how predictive analytics drive reimbursement optimization, with ... meeting in Orlando, June 25-28. , “The traditional approach to denied and ...
Breaking Medicine News(10 mins):
(Date:6/9/2017)... , June 9, 2017 More than 400 ... effort to help spread lessons learned from clinical research ... Diabetes Federation (IDF) and Eli Lilly and Company (NYSE: ... second phase of the Bringing Research in Diabetes to ... commitment to helping people with diabetes effectively manage their ...
(Date:6/7/2017)... -- Endo International plc (NASDAQ: ENDP ) ... Joseph R. Goodwin , U.S. District Court Judge for ... , entered a case management order in MDL 2325, ... Litigation (the "MDL") that includes a provision requiring plaintiffs ... on specific causation within one hundred twenty (120) days ...
(Date:6/5/2017)... , June 5, 2017 Kohll,s Pharmacy ... the United States . The Raizer is ... a fallen person up to an almost-standing position ... and operated by one assistant and does not ... is simple enough that a child can operate it, ...
Breaking Medicine Technology: