Navigation Links
JCI online ahead of print table of contents for May 16, 2014
Date:5/16/2014

dependent cell-mediated cytotoxicity (ADCC) in which the IgG1 constant fragment of cetuximab binds FcγR on NK cells to trigger degranulation. In this issue of the Journal of Clinical Investigation, Holbrook Kohrt and colleagues at Stanford University sought to identify inducible costimulatory molecules on NK cells that enhanced ADCC in an attempt to identify strategies to enhance the efficacy of cetuximab. The athours found that CD137 was upregulated after exposure to cetuximab-bound cancer cells. Using murine models of CRC and HNSCC, Kohrt and colleagues demonstrated that administration of cetuximab followed by an agonistic anti-CD137 antibody had a synergistic effect on NK cell degranulation and tumor-specific cytotoxicity, leading to prolonged survival. In an accompanying commentary, Julie Baumann and Jennifer Grandis of the University of Pittsburg discuss how strategies to enhance secondary immune responses to tumor-targeted antibodies might translate to the clinic.

TITLE: Targeting CD137 enhances the efficacy of cetuximab

AUTHOR CONTACT: Holbrook Kohrt
Stanford University, Stanford, CA, USA
Phone: 650 725-2988; Fax: 650 724-6182; E-mail: kohrt@stanford.edu

View this article at: http://www.jci.org/articles/view/73014

ACCOMPANYING COMMENTARY TITLE: Targeting secondary immune responses to cetuximab: CD137 and the outside story

AUTHOR CONTACT: Julie E. Bauman
Cancer Institute. University of Pittsburgh, Pittsburgh, PA, USA
Phone: 412-623-7833; Fax: 412-648-6579; E-mail: baumanje@upmc.edu

View this article at: http://www.jci.org/articles/view/76264


ALSO IN THIS ISSUE:

'/>"/>

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. New online portal, app provide information on tsunami zones in the Northwest
2. Being Ignored Feels Just as Bad Online
3. Online Tool Could Diagnose Autism Quickly, Developers Say
4. Online Dating Scams Can Take Emotional, Financial Toll
5. Annals of Internal Medicine tip sheet for May 8, 2012, online issue
6. Data release from the Allen Institute for Brain Science expands online atlas offerings
7. Vendors in Nevada, Michigan, & Illinois to be Featured on the PartyPOP.com Online Network
8. Annals of Internal Medicine tip sheet for June 19, 2012, online issue
9. Online weight loss programs that feature successful dieters may help
10. DotComSecrets’ Russell Brunson Is Revealing Online Money Making Secrets in Free Webinars for Students
11. DermaShoppe.com Celebrates Its Second Successful Year in Online Skin Care
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... 2014 (HealthDay News) -- Although there is mounting ... most middle-aged and older adults in the United ... according to new research. Less than one-quarter ... set by the Department of Health and Human ... essential for promoting health and fitness and staying ...
(Date:9/19/2014)... (PRWEB) September 19, 2014 The ... important partnership with the National Fire Protection Association ... The collaboration, formalized today in a Memorandum of ... Members, factories, workers and other stakeholders with information, ... help protect the health and safety of workers ...
(Date:9/19/2014)... to treat and cure disease is a hugely ... by the inability of doctors and scientists to effectively ... in patients without resorting to invasive procedures, like tissue ... the online journal Magnetic Resonance in Medicine , ... of Medicine, University of Pittsburgh and elsewhere describe the ...
(Date:9/19/2014)... 2014) - New research published today in the online ... could reach 6,800 in West Africa by the end ... enacted. , Arizona State University and Harvard University ... of rise in cases significantly increased in August in ... quarantine was put in place, indicating that the mass ...
(Date:9/19/2014)... Researchers at Jacksonville,s campus of Mayo Clinic have ... say contributes to both overproduction of toxic protein in ... well as loss of communication between neurons both ... study, in the online issue of Neuron ... defect with drugs "may rejuvenate or rescue this pathway," ...
Breaking Medicine News(10 mins):Health News:Adults Over 45 Not Meeting U.S. Muscle Strengthening Guidelines, Study Says 2Health News:Alliance for Bangladesh Worker Safety and NFPA Sign Memorandum of Understanding to Strengthen Safety in Bangladesh Garment Factories 2Health News:Alliance for Bangladesh Worker Safety and NFPA Sign Memorandum of Understanding to Strengthen Safety in Bangladesh Garment Factories 3Health News:A better way to track emerging cell therapies using MRIs 2Health News:Research predicts possible 6,800 new Ebola cases this month 2Health News:Mayo researchers reveal pathway that contributes to Alzheimer's disease 2
... Self-Funding,Healthcare Conference and Expo will provide employers and health ... both carriers and,brokers during a June 1-3, 2009 conference ... The conference is unique, as it is designed and ... Karrie Andes, Director of Human,Resources for Deffenbaugh Industries, ...
... (Nasdaq: DYNT ) today announced that a ... the SEC, gives the company until approximately June 28, ... bid rule."We are pleased that NASDAQ has further extended ... market environment," stated Kelvyn H. Cullimore Jr., chairman and ...
... tumors seen in mouse study , , MONDAY, Dec. 29 ... phosphates found in many natural and processed foods accelerated ... researchers report. , "Our study suggests that dietary regulation ... treatment as well as prevention," Myung-Haing Cho, lead author ...
... widespread media attention given to studies that have indicated ... new study shows just one-third of children who are ... pediatrician. The study, led by researchers at The ... Medicine in Cleveland, also stresses that this failure to ...
... Technology,Inc. ("Versus" or the "Company") announced revenues of ... compared to revenues of $5,566,000 for fiscal,year 2007. ... 31, 2008, were,$1,748,000 compared to revenues of $2,012,000 ... can vary significantly depending on the timing and,delivery ...
... MANHATTAN, KSThe Centers for Disease Control and Prevention and ... 30 minutes of moderate-intensity physical activity on most days ... optimal health. This recommendation is especially important for older ... requirement, yet are more at risk for chronic diseases ...
Cached Medicine News:Health News:Spending Too Much on Healthcare? This Employer-Designed Conference Will Inspire! 2Health News:NASDAQ Gives Dynatronics a Second Three-Month Extension for Minimum Bid Price Compliance 2Health News:Food Phosphates Might Spur Lung Cancer 2Health News:Food Phosphates Might Spur Lung Cancer 3Health News:Can't chalk it up to 'baby fat' 2Health News:Versus Technology Announces Fiscal Year Results 2Health News:Versus Technology Announces Fiscal Year Results 3Health News:Versus Technology Announces Fiscal Year Results 4Health News:Versus Technology Announces Fiscal Year Results 5Health News:Versus Technology Announces Fiscal Year Results 6Health News:Versus Technology Announces Fiscal Year Results 7Health News:Another reason to get your hands dirty 2
(Date:9/19/2014)... -- Five MinuteClinic walk-in medical clinics are opening inside select CVS/pharmacy ... clinics opened in Memphis and ... added in Springfield on September 24 and ... to open October 22.  MinuteClinic is the largest and fastest growing ... . The Memphis -area clinics ...
(Date:9/19/2014)... 19, 2014 According to ... (Benchtop, Mobile, Industrial, & Laboratory), Industry (Food, Pharmaceutical, ... & Rotary) & Geography - Global Trends & ... segments the lyophilization market on the basis of ... projections of the market size of each of ...
(Date:9/19/2014)... Mass. , Sept. 19, 2014  Pressure ... today announced it has received and approved all ... HT48 instruments and has begun to manufacture the ... first instrument will be ready for shipment by ... built and released at a rate of about ...
Breaking Medicine Technology:MinuteClinic Walk-in Medical Clinics Opening in Memphis 2MinuteClinic Walk-in Medical Clinics Opening in Memphis 3Lyophilization Market Worth $5,121.5 Million by 2019 2Lyophilization Market Worth $5,121.5 Million by 2019 3Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 2Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 3
BD Vacutainer® Heparin Tubes are spray-coated with either lithium heparin or sodium heparin and are used for plasma determinations in chemistry....
VACUETTE paediatric tubes have decreased sample volumes and are ideal for small childrens' veins and geriatric patients....
... Coagulation tubes contain a buffered ... available with a citrate concentration ... 0.129 mol/l (3.8%). The mixing ... solution to 9 parts blood. ...
... are available in two versions. ... a clotting activator and is ... serum is required for testing ... is suitable where the testing ...
Medicine Products: