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JCI online ahead of print table of contents for May 16, 2014
Date:5/16/2014

dependent cell-mediated cytotoxicity (ADCC) in which the IgG1 constant fragment of cetuximab binds FcγR on NK cells to trigger degranulation. In this issue of the Journal of Clinical Investigation, Holbrook Kohrt and colleagues at Stanford University sought to identify inducible costimulatory molecules on NK cells that enhanced ADCC in an attempt to identify strategies to enhance the efficacy of cetuximab. The athours found that CD137 was upregulated after exposure to cetuximab-bound cancer cells. Using murine models of CRC and HNSCC, Kohrt and colleagues demonstrated that administration of cetuximab followed by an agonistic anti-CD137 antibody had a synergistic effect on NK cell degranulation and tumor-specific cytotoxicity, leading to prolonged survival. In an accompanying commentary, Julie Baumann and Jennifer Grandis of the University of Pittsburg discuss how strategies to enhance secondary immune responses to tumor-targeted antibodies might translate to the clinic.

TITLE: Targeting CD137 enhances the efficacy of cetuximab

AUTHOR CONTACT: Holbrook Kohrt
Stanford University, Stanford, CA, USA
Phone: 650 725-2988; Fax: 650 724-6182; E-mail: kohrt@stanford.edu

View this article at: http://www.jci.org/articles/view/73014

ACCOMPANYING COMMENTARY TITLE: Targeting secondary immune responses to cetuximab: CD137 and the outside story

AUTHOR CONTACT: Julie E. Bauman
Cancer Institute. University of Pittsburgh, Pittsburgh, PA, USA
Phone: 412-623-7833; Fax: 412-648-6579; E-mail: baumanje@upmc.edu

View this article at: http://www.jci.org/articles/view/76264


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Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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