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JCI online ahead of print table of contents for May 16, 2014
Date:5/16/2014

d as well as or better than the vaccine. Further investigations revealed that vaccine alone induced higher numbers of myeloid-derived suppressor cells (MDSCs), which suppress the CD8+ T cell-mediated anti-viral response. Additionally, MDSC levels positively correlated with set-point viral loads, indicating that these cells critically affect vaccine efficacy. In the accompanying commentary, Sallie Permar and Herman Staats of Duke University discuss how these findings new finding may benefit future HIV vaccine design.

TITLE: Vaccine-induced myeloid cell population dampens protective immunity to SIV

AUTHOR CONTACT: Yongjun Sui
NCI, Bethesda, MD, USA
Phone: 301-435-8350; E-mail: suiy@mail.nih.gov

Or

Jay A. Berzofsky
NCI, Bethesda, MD, USA
Phone: 301.496.6874; Fax: 301.480.0681; E-mail: berzofsj@mail.nih.gov

View this article at: http://www.jci.org/articles/view/73518

ACCOMPANYING COMMENTARY TITLE: Which comes first: the antigen or the adjuvant?

AUTHOR CONTACT: Sallie Permar
Duke University, Durham, NC, USA
Phone: 919-684-6335; E-mail: sallie.permar@duke.edu

View this article at: http://www.jci.org/articles/view/76263


Enhancing efficacy of the cancer drug cetuximab

Cetuximab is a monoclonal antibody that targets EGFR, which is frequently mutated in various forms of cancer. Currently, cetuximab is FDA approved to treat colorectal cancer (CRC) and head and neck squamous cell carcinoma (HNSCC); however, only 10-20% of patients respond to cetuximab alone. The anti-tumor effects of cetuximab are mediated in part by antibody-
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Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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