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JCI online ahead of print table of contents for May 16, 2014
Date:5/16/2014

differences in therapeutic responses should be taken into consider for both treatment options and clinical trial design.

TITLE: PDE5 inhibitor efficacy is estrogen dependent in female heart disease

AUTHOR CONTACT: Eiki Takimoto
Johns Hopkins University School of Medicine, Baltimore, MD, USA
Phone: 410-955-4813; Fax: 410-502-2558; E-mail: etakimo1@jhmi.edu

View this article at: http://www.jci.org/articles/view/70731

ACCOMPANYING COMMENTARY TITLE: Sex, drugs, and trial design: sex influences the heart and drug responses

AUTHOR CONTACT: Elizabeth Murphy
NHLBI, NIH, Bethesda, MD, USA
Phone: 301.496.5828; E-mail: murphy1@nhlbi.nih.gov

View this article at: http://www.jci.org/articles/view/76262


Vaccine-induced cell population inhibits SIV vaccine efficacy

The development of an efficacious HIV vaccine has been challenging. Adjuvants are a critical addition to vaccines to help target and potentiate vaccine-induced immune responses, and several have been used in an attempt to boost HIV-specific immune response with limited success. In this issue of the Journal of Clinical Investigation, Yongjun Sui, Jay Berzofsky, and colleagues at the National Cancer institute examined the effect of different combinations of molecular adjuvants in an SIV vaccine that has previously been shown to provide some protection against rectal SIV challenge in macaques. Adjuvants included components that promote viral protection, improve T cell anti-viral responses, and also inhibit negative immune regulators. The vaccine with the full complement of adjuvants reduced viral load; however, adjuvant alone performe
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Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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