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JCI online ahead of print table of contents for March 18, 2014
Date:3/18/2014

ail: Heiko.Hermeking@med.uni-muenchen.de

View this article at: http://www.jci.org/articles/view/73531

ACCOMPANYING COMMENTARY TITLE: Microenvironment-dependent cues trigger miRNA-regulated feedback loop to facilitate the EMT/MET switch

AUTHOR CONTACT: Raghu Kalluri
University of Texas MD Anderson Cancer Center, Houston, TX, USA
Phone: 713-792-8586; E-mail: rkalluri@mdanderson.org

View this article at: http://www.jci.org/articles/view/75239?key=e516522eb60efe2d4b40


Insulin resistance in bone disrupts whole-body glucose homeostasis

Insulin signaling in osteoblasts mediates the activation of osteocalcin, which promotes insulin secretion in the pancreas and insulin sensitivity in other tissues. It is unknown if insulin resistance develops in bone in response to a high fat diet (HFD) and contributes to the disruption of glucose metabolism associated with the development of type 2 diabetes. In thie issue of the Journal of Clinical Investigation, Gerard Karsenty and colleagues of Columbia University determined that insulin resistance does develop in osteoblasts of mice fed a HFD and that this insulin resistance in bone cells contribute to the development of whole-body glucose intolerance through decreased circulation of active osteocalcin. Osteoblast-specific insulin resistance resulted, in part, from increased ubiquitination and degradation of the insulin receptor in response to saturated fatty acids. In the accompanying Commentary, Ryan Riddle and Thomas Clemens of Johns Hopkins University indicate that understanding the interplay between the skeletal system and whole-body metaboli
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Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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