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JCI online ahead of print table of contents for Feb. 24, 2014

etween healthy and malignant cells. In this issue of the , Stephan von Gunten and colleagues at the University of Bern determined that ligands of the inhibitory sialic acid-binding lectins Siglec-7 and Siglec-9 are expressed on the surface of multiple tumor cell types, and that expression of these ligands protects tumor cells from NK cell responses. Evaluation of NK cells in healthy donors revealed the presence of a Siglec-9-expressing cytotoxic NK cell population with enhanced chemotactic potential. Interestingly, the Siglec-9-expressing NK cell population was reduced in peripheral blood from patients with colon adenocarcinoma and malignant melanoma. These data suggest that targeting Siglec-7 and Siglec-9 ligands may enhance NK cell-based cancer therapies.

Interactions between Siglec-7/9 receptors and ligands influence NK celldependent tumor immunosurveillance

Stephan von Gunten
University of Bern, Bern, CHE
Phone: +41 31 632 32 98; Fax: +41 31 632 49 92; E-mail:

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IL-7 receptor blockade following T cell depletion promotes long-term allograft survival

Hoa-Le Mai
Phone: 33240087410; Fax: 33240087411; E-mail:

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Pegylated IFN-α regulates hepatic gene expression through transient Jak/STAT activation

Contact: JCI Media Contact
Journal of Clinical Investigation

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