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JCI online ahead of print table of contents for April 24, 2014
Date:4/24/2014

Ex vivo expansion of hematopoietic stem cells from cord blood

Compared to hematopoietic stem cells (HSCs) isolated from adults, HSCs isolated from cord blood (CB) have enhanced proliferative potential and can lead to hematological reconstitution when engrafted in children with hematological malignancies or genetic defects. Unfortunately, small numbers of HSCs are present in single CB collections, limiting their use as grafts for adults. For several decades investigators have used a variety of strategies to expand the numbers of CB HSC ex vivo with limited success. Evidence indicates that accumulation of epigenetic modifications influences preservation of stem cell characteristics in HSC daughter cells; therefore, in this issue of the Journal of Clinical Investigation, Pratima Chaurasia and colleagues at Mount Sinai School of Medicine expanded CB HSCs in the presence of histone deacetylase inhibitors (HDACIs) and evaluated their characteristics. Valproic acid (VPA)-treated CB HSCs produced greater numbers of HSCs that expressed several pluripotency genes. Compared to conventionally expanded CB HSCs, VPA-treated HSCs were more efficient in repopulating the bone marrow and establishing hematopoietic populations in immune deficient mice. In an accompanying Commentary, Hal Broxmeyer of the Indiana University School of Medicine discusses how these findings enhance our understanding of HSC function and could provide clinical benefit.

TITLE: Epigenetic reprogramming induces the expansion of cord blood stem cells

AUTHOR CONTACT: Ronald Hoffman
Mount Sinai School of Medicine, New York, NY, USA
Phone: 212-241-1948; Fax: 212-876-5276; E-mail: ronald.hoffman@mssm.edu

OR

Pratima Chaurasia
Mount Sinai School of Medicine, New York, NY, USA
Phone: 212.241.1766; Fax: 212.876.5276; E-mail: pratima
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Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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