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JCI online ahead of print contents for June 9, 2014
Date:6/9/2014

d colleagues at the Japanese Foundation for Cancer Research developed a murine model of Ewing's sarcoma by introducing EWS-ETS fusion genes into a late gestational cell fraction enriched for osteochondrogenic progenitors from the embryonic superficial zone (eSZ) of the long bones The model tumors shared a gene expression profile with human Ewing's sarcoma and both murine and human tumors exhibited upregulated of WNT/β-catenin and EGF signaling. Finally, inhibitors of the WNT/β-catenin pathway attenuated murine tumor growth. This model provides a tool to evaluate potential therapies for treatment of this rare disease.

TITLE: Ewing's sarcoma precursors are highly enriched in embryonic osteochondrogenic progenitors

AUTHOR CONTACT: Takuro Nakamura
The Cancer Institute, Tokyo, JPN
Phone: 81-3-3570-0462; Fax: 81-3-3570-0463; E-mail: takuro-ind@umin.net

View this article at: http://www.jci.org/articles/view/72399


ALSO IN THIS ISSUE

AGING

TITLE: Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging

AUTHOR CONTACT: Dmitry Bulavin
Institute Of Molecular And Cellular Biology, Singapore, SGP
Phone: 65-65869589; E-mail: dvbulavin@imcb.a-star.edu.sg

View this article at: http://www.jci.org/articles/view/73015

BONE BIOLOGY

TITLE: Vitamin B12dependent taurine synthesis regulates growth and bone mass

AUTHOR CONTACT: Vijay Yadav
Wellcome Trust Sanger Institute, Cambridge, GBR
Phone: +44-01223-496948; E-mail: vy1@sanger.ac.uk


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Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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