Navigation Links
JCI online ahead of print contents for June 9, 2014

Clinical trial evaluates ex vivo cultured cord blood

Umbilical cord blood (UCB) is a rich source of hematopoietic stem and progenitor cells (HSPCs) that can be used for bone marrow transplantation; however, UCB transplantation is hampered by low numbers of HSPCs per donation, which delays engraftment and immune reconstitution. In this issue of the Journal of Clinical Investigation, Mitchell Horwitz and colleagues at Duke University Medical Center conducted a phase I clinical trial to test the long term engraftment capability of UCB HSPCs that were expanded ex vivo for 21 days in the presence of nicotinamide and then combined with the non-cultured T cell fraction of the UCB (NiCord). Eleven adults with hematological malignancies received 1 unit of NiCord and a second unit of un-manipulated UCB following myeloablative bone marrow conditioning. Eight patients exhibited complete or partial engraftment of the NiCord unit and achieved earlier hematopoietic recovery compared to historical controls. These results indicate that further clinical study of NiCord is warranted.

TITLE: Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment

AUTHOR CONTACT: Mitchell Horwitz
Duke University Medical Center, Durham, NC, USA
Phone: 919-668-1045; E-mail:

View this article at:

Murine model of Ewing's sarcoma reveals tumor origins

Ewing's sarcoma is a rare pediatric bone tumor that results from a genetic translocation that results in an EWS-ETS fusion. The tumor can have both mesodermal and ectodermal features, making it difficult to determine the cellular origin. In this issue of the Journal of Clinical Investigation, Takuro Nakamura and colleagues at the Japanese Foundation for Cancer Research developed a murine model of Ewing's sarcoma by introducing EWS-ETS fusion genes into a late gestational cell fraction enriched for osteochondrogenic progenitors from the embryonic superficial zone (eSZ) of the long bones The model tumors shared a gene expression profile with human Ewing's sarcoma and both murine and human tumors exhibited upregulated of WNT/β-catenin and EGF signaling. Finally, inhibitors of the WNT/β-catenin pathway attenuated murine tumor growth. This model provides a tool to evaluate potential therapies for treatment of this rare disease.

TITLE: Ewing's sarcoma precursors are highly enriched in embryonic osteochondrogenic progenitors

AUTHOR CONTACT: Takuro Nakamura
The Cancer Institute, Tokyo, JPN
Phone: 81-3-3570-0462; Fax: 81-3-3570-0463; E-mail:

View this article at:



TITLE: Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging

AUTHOR CONTACT: Dmitry Bulavin
Institute Of Molecular And Cellular Biology, Singapore, SGP
Phone: 65-65869589; E-mail:

View this article at:


TITLE: Vitamin B12dependent taurine synthesis regulates growth and bone mass

Wellcome Trust Sanger Institute, Cambridge, GBR
Phone: +44-01223-496948; E-mail:

View this article at:


TITLE: Hypomorphic PCNA mutation underlies a human DNA repair disorder

University of Exeter Medical School, Exeter, GBR
Phone: +44 (0)1392 408302; E-mail:

View this article at:


TITLE: Characterization of pandemic influenza immune memory signature after vaccination or infection

AUTHOR CONTACT: Behazine Combadiere
INSERM UMR 1135, Paris, , FRA
Phone: +33140779888; Fax: +33140779734; E-mail:

View this article at:

TITLE: Immune activation alters cellular and humoral responses to yellow fever 17D vaccine

AUTHOR CONTACT: Lydie Trautmann
Vaccine and Gene Therapy Institute-Florida, Port Saint Lucie, FL, USA
Phone: 772-345-5671; Fax: 772-345-0625; E-mail:

View this article at:


TITLE: Missense dopamine transporter mutations associate with adult parkinsonism and ADHD

University of Copenhagen, DK-2200 Copenhagen N, Denmark
Phone: 45.2384.0089; Fax: 45.3532.7610; E-mail:

View this article at:


TITLE: CRIPTO1 expression in EGFR-mutant NSCLC elicits intrinsic EGFR-inhibitor resistance

AUTHOR CONTACT: Giuseppe Giaccone
Georgetown University, Washington, DC, USA
Phone: 202.687.7072; Fax: 202.687.0313;


Yisong Wang
Georgetown University, Washington, DC, USA
Phone: 202.687.4738; Fax: 202.687.0313;

View this article at:

TITLE: MicroRNA-205 signaling regulates mammary stem cell fate and tumorigenesis

AUTHOR CONTACT: Chun-Ju (Alice) Chang
Purdue University, West Lafayette, USA
Phone: 7654942648; E-mail:

View this article at:


Contact: Corinne Williams
Journal of Clinical Investigation

Related medicine news :

1. New online portal, app provide information on tsunami zones in the Northwest
2. Being Ignored Feels Just as Bad Online
3. Online Tool Could Diagnose Autism Quickly, Developers Say
4. Online Dating Scams Can Take Emotional, Financial Toll
5. Annals of Internal Medicine tip sheet for May 8, 2012, online issue
6. Data release from the Allen Institute for Brain Science expands online atlas offerings
7. Vendors in Nevada, Michigan, & Illinois to be Featured on the Online Network
8. Annals of Internal Medicine tip sheet for June 19, 2012, online issue
9. Online weight loss programs that feature successful dieters may help
10. DotComSecrets’ Russell Brunson Is Revealing Online Money Making Secrets in Free Webinars for Students
11. Celebrates Its Second Successful Year in Online Skin Care
Post Your Comments:
(Date:6/27/2016)... Brooklyn, NY (PRWEB) , ... June 27, 2016 ... ... is using cutting edge technology to revolutionize the emergency ambulance transport experience for ... Many are aware of how Uber has disrupted the taxi industry through the ...
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A ... 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the ... history as home to some of the world’s leading providers of cereal and other ...
(Date:6/26/2016)... ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is ... a fitness app. The fitness app plans to fix the two major problems leading the ... one size fits all type program , They don’t eliminate all the reasons ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... Austin residents ... the American College of Mohs Surgery and to Dr. Russell Peckham for medical and ... highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed ...
(Date:6/25/2016)... , ... June 25, 2016 , ... First Choice ... States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm ... Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016  MedSource announced today ... its e-clinical software solution of choice.  This latest ... possible value to their clients by offering a ... preferred relationship establishes nowEDC as the EDC platform ... MedSource,s full-service clients.  "nowEDC has long been a ...
(Date:6/23/2016)... 23, 2016  In a startling report released today, National ... by lacking a comprehensive, proven plan to eliminate prescription opioid overdoses. ... of how states are tackling the worst drug crisis in recorded ... – Kentucky , New Mexico ... . Of the 28 failing states, three – Michigan ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... their offering. The current ... environment for MedImmune to enter. The US ageing population creates ... drive considerable growth for effective anti-influenza medications. The introduction of ... but development is still in its infancy. ...
Breaking Medicine Technology: