Navigation Links
JCI online ahead of print contents for June 9, 2014

Clinical trial evaluates ex vivo cultured cord blood

Umbilical cord blood (UCB) is a rich source of hematopoietic stem and progenitor cells (HSPCs) that can be used for bone marrow transplantation; however, UCB transplantation is hampered by low numbers of HSPCs per donation, which delays engraftment and immune reconstitution. In this issue of the Journal of Clinical Investigation, Mitchell Horwitz and colleagues at Duke University Medical Center conducted a phase I clinical trial to test the long term engraftment capability of UCB HSPCs that were expanded ex vivo for 21 days in the presence of nicotinamide and then combined with the non-cultured T cell fraction of the UCB (NiCord). Eleven adults with hematological malignancies received 1 unit of NiCord and a second unit of un-manipulated UCB following myeloablative bone marrow conditioning. Eight patients exhibited complete or partial engraftment of the NiCord unit and achieved earlier hematopoietic recovery compared to historical controls. These results indicate that further clinical study of NiCord is warranted.

TITLE: Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment

AUTHOR CONTACT: Mitchell Horwitz
Duke University Medical Center, Durham, NC, USA
Phone: 919-668-1045; E-mail:

View this article at:

Murine model of Ewing's sarcoma reveals tumor origins

Ewing's sarcoma is a rare pediatric bone tumor that results from a genetic translocation that results in an EWS-ETS fusion. The tumor can have both mesodermal and ectodermal features, making it difficult to determine the cellular origin. In this issue of the Journal of Clinical Investigation, Takuro Nakamura and colleagues at the Japanese Foundation for Cancer Research developed a murine model of Ewing's sarcoma by introducing EWS-ETS fusion genes into a late gestational cell fraction enriched for osteochondrogenic progenitors from the embryonic superficial zone (eSZ) of the long bones The model tumors shared a gene expression profile with human Ewing's sarcoma and both murine and human tumors exhibited upregulated of WNT/β-catenin and EGF signaling. Finally, inhibitors of the WNT/β-catenin pathway attenuated murine tumor growth. This model provides a tool to evaluate potential therapies for treatment of this rare disease.

TITLE: Ewing's sarcoma precursors are highly enriched in embryonic osteochondrogenic progenitors

AUTHOR CONTACT: Takuro Nakamura
The Cancer Institute, Tokyo, JPN
Phone: 81-3-3570-0462; Fax: 81-3-3570-0463; E-mail:

View this article at:



TITLE: Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging

AUTHOR CONTACT: Dmitry Bulavin
Institute Of Molecular And Cellular Biology, Singapore, SGP
Phone: 65-65869589; E-mail:

View this article at:


TITLE: Vitamin B12dependent taurine synthesis regulates growth and bone mass

Wellcome Trust Sanger Institute, Cambridge, GBR
Phone: +44-01223-496948; E-mail:

View this article at:


TITLE: Hypomorphic PCNA mutation underlies a human DNA repair disorder

University of Exeter Medical School, Exeter, GBR
Phone: +44 (0)1392 408302; E-mail:

View this article at:


TITLE: Characterization of pandemic influenza immune memory signature after vaccination or infection

AUTHOR CONTACT: Behazine Combadiere
INSERM UMR 1135, Paris, , FRA
Phone: +33140779888; Fax: +33140779734; E-mail:

View this article at:

TITLE: Immune activation alters cellular and humoral responses to yellow fever 17D vaccine

AUTHOR CONTACT: Lydie Trautmann
Vaccine and Gene Therapy Institute-Florida, Port Saint Lucie, FL, USA
Phone: 772-345-5671; Fax: 772-345-0625; E-mail:

View this article at:


TITLE: Missense dopamine transporter mutations associate with adult parkinsonism and ADHD

University of Copenhagen, DK-2200 Copenhagen N, Denmark
Phone: 45.2384.0089; Fax: 45.3532.7610; E-mail:

View this article at:


TITLE: CRIPTO1 expression in EGFR-mutant NSCLC elicits intrinsic EGFR-inhibitor resistance

AUTHOR CONTACT: Giuseppe Giaccone
Georgetown University, Washington, DC, USA
Phone: 202.687.7072; Fax: 202.687.0313;


Yisong Wang
Georgetown University, Washington, DC, USA
Phone: 202.687.4738; Fax: 202.687.0313;

View this article at:

TITLE: MicroRNA-205 signaling regulates mammary stem cell fate and tumorigenesis

AUTHOR CONTACT: Chun-Ju (Alice) Chang
Purdue University, West Lafayette, USA
Phone: 7654942648; E-mail:

View this article at:


Contact: Corinne Williams
Journal of Clinical Investigation

Related medicine news :

1. New online portal, app provide information on tsunami zones in the Northwest
2. Being Ignored Feels Just as Bad Online
3. Online Tool Could Diagnose Autism Quickly, Developers Say
4. Online Dating Scams Can Take Emotional, Financial Toll
5. Annals of Internal Medicine tip sheet for May 8, 2012, online issue
6. Data release from the Allen Institute for Brain Science expands online atlas offerings
7. Vendors in Nevada, Michigan, & Illinois to be Featured on the Online Network
8. Annals of Internal Medicine tip sheet for June 19, 2012, online issue
9. Online weight loss programs that feature successful dieters may help
10. DotComSecrets’ Russell Brunson Is Revealing Online Money Making Secrets in Free Webinars for Students
11. Celebrates Its Second Successful Year in Online Skin Care
Post Your Comments:
(Date:11/27/2015)... ... November 27, 2015 , ... Intellitec Solutions ... SL User Group (MSDSLUG). Recognized as Microsoft’s official group for end users of ... SL software users, partners, industry experts and representatives. Intellitec Solutions’ membership status demonstrates ...
(Date:11/27/2015)... ... November 27, 2015 , ... The men and women ... healthcare organizations in the country. They have overseen financial turnarounds, shown commitment to ... the healthcare industry as a whole through their advocacy and professional efforts. , ...
(Date:11/26/2015)... ... November 26, 2015 , ... Inevitably when people think Thanksgiving, ... choose to buy during the Black Friday and Cyber Monday massage chair sales ... search the Internet high and low to find the best massage chair deals, they ...
(Date:11/26/2015)... (PRWEB) , ... November 26, 2015 , ... PRMA Plastic ... November 19, 2015, our surgeons performed their 6,000th free flap breast reconstruction surgery! , ... wake up every day excited to rebuild lives and it’s an honor to have ...
(Date:11/25/2015)... OAK BROOK, Ill. (PRWEB) , ... November 25, ... ... sometimes larger and potentially more aggressive than those found on mammography, according to ... cases MRI findings of additional cancers not seen on mammography may necessitate a ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... DUBLIN , Nov. 26, 2015 ... the addition of the "2016 Future Horizons ... Monitoring (TDM) Market: Supplier Shares, Country Segment Forecasts, ... offering. --> ... comprehensive analysis of the Italian therapeutic drug monitoring ...
(Date:11/25/2015)... , Nov. 26, 2015  The total global healthcare ... 7% over 2015-2016. Latin America has ... , (excluding Japan ), is second ... continues to face increased healthcare expenditure. In 2013-2014, total ... declined from 43.5% in 2008-2009 to 41.2% in 2013-2014. In ...
(Date:11/25/2015)... , Nov. 25, 2015 AAIPharma Services ... investment of at least $15.8  Million to expand ... Wilmington, NC . The expansion will provide ... meet the growing demands of the pharmaceutical and ... site expansion will provide up to 40,000 square ...
Breaking Medicine Technology: