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JCI online ahead of print contents for June 9, 2014
Date:6/9/2014

Clinical trial evaluates ex vivo cultured cord blood

Umbilical cord blood (UCB) is a rich source of hematopoietic stem and progenitor cells (HSPCs) that can be used for bone marrow transplantation; however, UCB transplantation is hampered by low numbers of HSPCs per donation, which delays engraftment and immune reconstitution. In this issue of the Journal of Clinical Investigation, Mitchell Horwitz and colleagues at Duke University Medical Center conducted a phase I clinical trial to test the long term engraftment capability of UCB HSPCs that were expanded ex vivo for 21 days in the presence of nicotinamide and then combined with the non-cultured T cell fraction of the UCB (NiCord). Eleven adults with hematological malignancies received 1 unit of NiCord and a second unit of un-manipulated UCB following myeloablative bone marrow conditioning. Eight patients exhibited complete or partial engraftment of the NiCord unit and achieved earlier hematopoietic recovery compared to historical controls. These results indicate that further clinical study of NiCord is warranted.

TITLE: Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment

AUTHOR CONTACT: Mitchell Horwitz
Duke University Medical Center, Durham, NC, USA
Phone: 919-668-1045; E-mail: mitchell.horwitz@duke.edu

View this article at: http://www.jci.org/articles/view/74556


Murine model of Ewing's sarcoma reveals tumor origins

Ewing's sarcoma is a rare pediatric bone tumor that results from a genetic translocation that results in an EWS-ETS fusion. The tumor can have both mesodermal and ectodermal features, making it difficult to determine the cellular origin. In this issue of the Journal of Clinical Investigation, Takuro Nakamura an
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Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
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