Navigation Links
JCI early table of contents for Sept. 9, 2013
Date:9/9/2013

Study identifies fibroblast growth factor 18 as an ovarian cancer biomarker

Ovarian cancer is one of the leading causes of cancer-related death in women and is often not detected until the later stages of disease, which contributes to poor prognosis. Biomarkers that can be used for early diagnosis and outcome have been identified; however, many of these have not been evaluated at the biological and clinical levels. In this issue of the Journal of Clinical Investigation, Michael Birrer and colleagues at Massachusetts General Hospital identify fibroblast growth factor 18 (FGF18) as a predictive marker for poor overall survival in ovarian cancer patients. Overexpression of the gene encoding FGF18 was associated with enhanced tumor blood vessel formation and expression of cancer promoting cytokines. These data indicate that further studies on the predictive potential FGF18 and its use as a therapeutic target in ovarian cancer are warranted.

TITLE: FGF18 as a prognostic and therapeutic biomarker in ovarian cancer

AUTHOR CONTACT: Michael Birrer
Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Phone: 617-724-4800; E-mail: mbirrer@partners.org

View this article at: http://www.jci.org/articles/view/70625?key=0daf1c1350c8820558ad


Insulin secretion disrupted by increased fatty acids

Patients with type 2 diabetes have increased levels of circulating glucose and fatty acids, which lead to disease complications. In healthy individuals, β cells within pancreatic islets release insulin in response to glucose and incretins, which are gastrointestinal hormones. Coordination between β cells is predicted to be important for insulin release. In this issue of the Journal of Clinical Investigation, David Hodson and colleagues at Imperial College London demonstrate that β cell-β cell interactions are important for insulin secretion in human islets and that these interactions are regulated by incretins. The authors found that increased fatty acid levels suppressed incretin-associated insulin release. These findings indicate that therapies aimed at maintaining β cell connectivity may be useful for restoring glucose balance in type 2 diabetes.

TITLE: Lipotoxicity disrupts incretin-regulated human β cell connectivity

AUTHOR CONTACT: David Hodson
Imperial College London, London, , GBR
Phone: 447812029560; E-mail: d.hodson@imperial.ac.uk

View this article at: http://www.jci.org/articles/view/68459?key=b5c05d603bada96f2ee1


ALSO IN THIS ISSUE

TITLE: Proximal Tubule H-Ferritin Mediates Iron Trafficking in Acute Kidney Injury

AUTHOR CONTACT: Anupam Agarwal
U of Alabama @Birmingham, Birmingham, AL, USA
Phone: 2059966670; E-mail: agarwal@uab.edu

View this article at: http://www.jci.org/articles/view/67867?key=d327ac1d4de2473f2135

TITLE: Retinal angiogenesis suppression through small molecule activation of p53

AUTHOR CONTACT: Sai Chavala
The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Phone: 2168490437; E-mail: schavala@med.unc.edu

View this article at: http://www.jci.org/articles/view/67315?key=6b395836741fc796cd8e

TITLE: Thrombospondin-1 mediates oncogenic Ras-induced senescence in pre-malignant lung tumors

AUTHOR CONTACT: Sandra Ryeom
University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Phone: 215-573-5857; Fax: 215-573-2014; E-mail: sryeom@upenn.edu

View this article at: http://www.jci.org/articles/view/67465?key=df1a3976bda4a6a3ad15

TITLE: Perturbation of NK cell peripheral homeostasis accelerates prostate carcinoma metastasis

AUTHOR CONTACT: Jennifer Wu
University of Washington, Seattle, WA, USA
Phone: (206)3415349; Fax: (206)3415302; E-mail: wuj@u.washington.edu

View this article at: http://www.jci.org/articles/view/69369?key=022f7a3c4c93862b248c


'/>"/>

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Related medicine news :

1. KORT Physical Therapy and Healthcare Reform: Early Intervention Drives Costs Down for Patients, Insurance Companies
2. Covance and the Indiana CTSI to collaborate on early clinical research
3. New method for early detection of colon cancer
4. Diet Doc Medical Weight Loss Plans Now Helps Women Lose Weight Fast Before Early Pregnancy to Reduce Risks of Premature Death for their Children
5. Diet Doc Weight Loss Plans Reveals New Fat Loss Diet Pills to Eliminate Fat Before Early Pregnancy Weight Can Affect Future Offspring
6. Early Detection Services at Dedicated Breast Center
7. New screening strategy may catch ovarian cancer at early stages
8. CA-125 change over time shows promise as screening tool for early detection of ovarian cancer
9. PearlyPenilePapules.co.uk Launches an Effective Pearly Penile Papules Removal Service
10. San Diego Dermatologist Discusses Most Effective Treatment for Pearly Penile Papules (PPP)
11. Use of tPA for ischemic stroke nearly doubled from 2003 to 2011
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... February 22, 2017 , ... Doctors on Liens is continuing ... ophthalmologist, Dr. Steven H. Rauchman, practicing at North Valley Eye Medical Group in ... liability, premise liability and other personal injury cases. These injuries have a major ...
(Date:2/22/2017)... ... February 22, 2017 , ... Using the power of the internet, IdrisArkette.com ... checklist. Over a period of just 24 months, thousands of individuals interested in a ... called T.A.D. , “The internet is not getting quieter. In fact it’s becoming noisier ...
(Date:2/22/2017)... , ... February 22, 2017 , ... ... contract to Quality Insights to help small practices in Delaware, New Jersey, Pennsylvania ... established by the Medicare Access and CHIP Reauthorization Act of 2015 (MACRA). ...
(Date:2/22/2017)... , ... February 22, 2017 , ... A product of ... seem to derive a heart-protective benefit from eating soy foods, while others do not, ... men who are able to produce equol—a substance made by some types of “good” ...
(Date:2/22/2017)... ... February 22, 2017 , ... The SeniorCare Investor will host an important ... February 23, 2017, at 1:00 PM ET. A recording of the webinar will also ... Webinar Series. , If you want to find out what really happened in the ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... , Colombie-Britannique, February 22, 2017 Des scanners sur ... vente en Europe , au Moyen-Orient et en Afrique  ... Clarius Mobile Health , ... Vancouver , au Canada , a annoncé ... des Scanners Échographiques Sans fil Clarius C3 et L7, destinés à être ...
(Date:2/22/2017)... NeuroVive Pharmaceutical AB (Nasdaq Stockholm: NVP, ... new research agreements and the appointment of Professor ... , MD, PhD, FRCP, as scientific advisors. The aim ... drug compounds in development for the treatment of NASH ... new collaboration with Philippe Gallay , the research ...
(Date:2/21/2017)... , Feb. 21, 2017 Mass ... report: http://www.reportlinker.com/p04711309-summary/view-report.html This report ... well as future prospects of the market globally. ... intermediaries engaged in the manufacture and commercialization of ... as new entrants planning to enter this market. ...
Breaking Medicine Technology: