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JCI early table of contents for Sept. 9, 2013

Study identifies fibroblast growth factor 18 as an ovarian cancer biomarker

Ovarian cancer is one of the leading causes of cancer-related death in women and is often not detected until the later stages of disease, which contributes to poor prognosis. Biomarkers that can be used for early diagnosis and outcome have been identified; however, many of these have not been evaluated at the biological and clinical levels. In this issue of the Journal of Clinical Investigation, Michael Birrer and colleagues at Massachusetts General Hospital identify fibroblast growth factor 18 (FGF18) as a predictive marker for poor overall survival in ovarian cancer patients. Overexpression of the gene encoding FGF18 was associated with enhanced tumor blood vessel formation and expression of cancer promoting cytokines. These data indicate that further studies on the predictive potential FGF18 and its use as a therapeutic target in ovarian cancer are warranted.

TITLE: FGF18 as a prognostic and therapeutic biomarker in ovarian cancer

AUTHOR CONTACT: Michael Birrer
Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Phone: 617-724-4800; E-mail:

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Insulin secretion disrupted by increased fatty acids

Patients with type 2 diabetes have increased levels of circulating glucose and fatty acids, which lead to disease complications. In healthy individuals, β cells within pancreatic islets release insulin in response to glucose and incretins, which are gastrointestinal hormones. Coordination between β cells is predicted to be important for insulin release. In this issue of the Journal of Clinical Investigation, David Hodson and colleagues at Imperial College London demonstrate that β cell-β cell interactions are important for insulin secretion in human islets and that these interactions are regulated by incretins. The authors found that increased fatty acid levels suppressed incretin-associated insulin release. These findings indicate that therapies aimed at maintaining β cell connectivity may be useful for restoring glucose balance in type 2 diabetes.

TITLE: Lipotoxicity disrupts incretin-regulated human β cell connectivity

Imperial College London, London, , GBR
Phone: 447812029560; E-mail:

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TITLE: Proximal Tubule H-Ferritin Mediates Iron Trafficking in Acute Kidney Injury

AUTHOR CONTACT: Anupam Agarwal
U of Alabama @Birmingham, Birmingham, AL, USA
Phone: 2059966670; E-mail:

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TITLE: Retinal angiogenesis suppression through small molecule activation of p53

The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Phone: 2168490437; E-mail:

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TITLE: Thrombospondin-1 mediates oncogenic Ras-induced senescence in pre-malignant lung tumors

University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Phone: 215-573-5857; Fax: 215-573-2014; E-mail:

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TITLE: Perturbation of NK cell peripheral homeostasis accelerates prostate carcinoma metastasis

University of Washington, Seattle, WA, USA
Phone: (206)3415349; Fax: (206)3415302; E-mail:

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Contact: Corinne Williams
Journal of Clinical Investigation

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