Navigation Links
JCI early table of contents for Sept. 9, 2013
Date:9/9/2013

Study identifies fibroblast growth factor 18 as an ovarian cancer biomarker

Ovarian cancer is one of the leading causes of cancer-related death in women and is often not detected until the later stages of disease, which contributes to poor prognosis. Biomarkers that can be used for early diagnosis and outcome have been identified; however, many of these have not been evaluated at the biological and clinical levels. In this issue of the Journal of Clinical Investigation, Michael Birrer and colleagues at Massachusetts General Hospital identify fibroblast growth factor 18 (FGF18) as a predictive marker for poor overall survival in ovarian cancer patients. Overexpression of the gene encoding FGF18 was associated with enhanced tumor blood vessel formation and expression of cancer promoting cytokines. These data indicate that further studies on the predictive potential FGF18 and its use as a therapeutic target in ovarian cancer are warranted.

TITLE: FGF18 as a prognostic and therapeutic biomarker in ovarian cancer

AUTHOR CONTACT: Michael Birrer
Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Phone: 617-724-4800; E-mail: mbirrer@partners.org

View this article at: http://www.jci.org/articles/view/70625?key=0daf1c1350c8820558ad


Insulin secretion disrupted by increased fatty acids

Patients with type 2 diabetes have increased levels of circulating glucose and fatty acids, which lead to disease complications. In healthy individuals, β cells within pancreatic islets release insulin in response to glucose and incretins, which are gastrointestinal hormones. Coordination between β cells is predicted to be important for insulin release. In this issue of the Journal of Clinical Investigation, David Hodson and colleagues at Imperial College London demonstrate that β cell-β cell interactions are important for insulin secretion in human islets and that these interactions are regulated by incretins. The authors found that increased fatty acid levels suppressed incretin-associated insulin release. These findings indicate that therapies aimed at maintaining β cell connectivity may be useful for restoring glucose balance in type 2 diabetes.

TITLE: Lipotoxicity disrupts incretin-regulated human β cell connectivity

AUTHOR CONTACT: David Hodson
Imperial College London, London, , GBR
Phone: 447812029560; E-mail: d.hodson@imperial.ac.uk

View this article at: http://www.jci.org/articles/view/68459?key=b5c05d603bada96f2ee1


ALSO IN THIS ISSUE

TITLE: Proximal Tubule H-Ferritin Mediates Iron Trafficking in Acute Kidney Injury

AUTHOR CONTACT: Anupam Agarwal
U of Alabama @Birmingham, Birmingham, AL, USA
Phone: 2059966670; E-mail: agarwal@uab.edu

View this article at: http://www.jci.org/articles/view/67867?key=d327ac1d4de2473f2135

TITLE: Retinal angiogenesis suppression through small molecule activation of p53

AUTHOR CONTACT: Sai Chavala
The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Phone: 2168490437; E-mail: schavala@med.unc.edu

View this article at: http://www.jci.org/articles/view/67315?key=6b395836741fc796cd8e

TITLE: Thrombospondin-1 mediates oncogenic Ras-induced senescence in pre-malignant lung tumors

AUTHOR CONTACT: Sandra Ryeom
University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Phone: 215-573-5857; Fax: 215-573-2014; E-mail: sryeom@upenn.edu

View this article at: http://www.jci.org/articles/view/67465?key=df1a3976bda4a6a3ad15

TITLE: Perturbation of NK cell peripheral homeostasis accelerates prostate carcinoma metastasis

AUTHOR CONTACT: Jennifer Wu
University of Washington, Seattle, WA, USA
Phone: (206)3415349; Fax: (206)3415302; E-mail: wuj@u.washington.edu

View this article at: http://www.jci.org/articles/view/69369?key=022f7a3c4c93862b248c


'/>"/>

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Related medicine news :

1. KORT Physical Therapy and Healthcare Reform: Early Intervention Drives Costs Down for Patients, Insurance Companies
2. Covance and the Indiana CTSI to collaborate on early clinical research
3. New method for early detection of colon cancer
4. Diet Doc Medical Weight Loss Plans Now Helps Women Lose Weight Fast Before Early Pregnancy to Reduce Risks of Premature Death for their Children
5. Diet Doc Weight Loss Plans Reveals New Fat Loss Diet Pills to Eliminate Fat Before Early Pregnancy Weight Can Affect Future Offspring
6. Early Detection Services at Dedicated Breast Center
7. New screening strategy may catch ovarian cancer at early stages
8. CA-125 change over time shows promise as screening tool for early detection of ovarian cancer
9. PearlyPenilePapules.co.uk Launches an Effective Pearly Penile Papules Removal Service
10. San Diego Dermatologist Discusses Most Effective Treatment for Pearly Penile Papules (PPP)
11. Use of tPA for ischemic stroke nearly doubled from 2003 to 2011
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/23/2017)... , ... August 23, 2017 , ... Drs. Steven White ... in Cornelius, NC. By taking advantage of this offer, valued at more than ... regular six-month hygiene cleaning from the dentist, patients receive a complimentary professional whitening procedure. ...
(Date:8/23/2017)... ... August 23, 2017 , ... ... to prove the safety and efficacy of HBOT in treating and helping to ... US, points to research showing the similarities of the wounds to the brain ...
(Date:8/23/2017)... (PRWEB) , ... August 23, 2017 , ... The Stevie® Awards have announced the winners ... Awards , the world’s premier business awards competition. , Nominees in the 2017 IBAs were ... by a points system based on the total number of awards won in the IBAs ...
(Date:8/23/2017)... ... August 23, 2017 , ... PreCheck, Inc., a ... 2017 Inc. 5000 with a three-year sales growth of 49 percent . The ... comprises the most comprehensive look at America’s independent entrepreneurs. This represents PreCheck’s fifth ...
(Date:8/23/2017)... ... August 23, 2017 , ... Arizona Spine ... nationally that earned the designation of High Performing Hospitals by U.S. News & World ... indicates a hospital was significantly better than the national average in a given ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... 7, 2017 Zimmer Biomet Holdings, Inc. (NYSE and ... that its Board of Directors has approved the payment of ... of 2017. The cash ... about October 27, 2017 to stockholders of record as of ... of dividends are subject to approval of the Board of ...
(Date:8/7/2017)... Inc. (NYSE: DPLO), the nation,s largest independent specialty pharmacy, announced ... comparisons, unless otherwise noted, are to the quarter ended June ... Quarter 2017 Highlights include: Revenue of ... Total prescriptions dispensed of 220,000, compared to ... Gross profit per prescription dispensed of ...
(Date:8/4/2017)... -- The search for test results that can be ... long been the goal of healthcare providers and the ... largest meeting of lab professionals and IVD firms this ... Kalorama Information.  The firm said scores of companies with ... and software were at the American Association for Clinical ...
Breaking Medicine Technology: