Navigation Links
JCI early table of contents for Sept. 9, 2013
Date:9/9/2013

Study identifies fibroblast growth factor 18 as an ovarian cancer biomarker

Ovarian cancer is one of the leading causes of cancer-related death in women and is often not detected until the later stages of disease, which contributes to poor prognosis. Biomarkers that can be used for early diagnosis and outcome have been identified; however, many of these have not been evaluated at the biological and clinical levels. In this issue of the Journal of Clinical Investigation, Michael Birrer and colleagues at Massachusetts General Hospital identify fibroblast growth factor 18 (FGF18) as a predictive marker for poor overall survival in ovarian cancer patients. Overexpression of the gene encoding FGF18 was associated with enhanced tumor blood vessel formation and expression of cancer promoting cytokines. These data indicate that further studies on the predictive potential FGF18 and its use as a therapeutic target in ovarian cancer are warranted.

TITLE: FGF18 as a prognostic and therapeutic biomarker in ovarian cancer

AUTHOR CONTACT: Michael Birrer
Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Phone: 617-724-4800; E-mail: mbirrer@partners.org

View this article at: http://www.jci.org/articles/view/70625?key=0daf1c1350c8820558ad


Insulin secretion disrupted by increased fatty acids

Patients with type 2 diabetes have increased levels of circulating glucose and fatty acids, which lead to disease complications. In healthy individuals, β cells within pancreatic islets release insulin in response to glucose and incretins, which are gastrointestinal hormones. Coordination between β cells is predicted to be important for insulin release. In this issue of the Journal of Clinical Investigation, David Hodson and colleagues at Imperial College London demonstrate that β cell-β cell interactions are important for insulin secretion in human islets and that these interactions are regulated by incretins. The authors found that increased fatty acid levels suppressed incretin-associated insulin release. These findings indicate that therapies aimed at maintaining β cell connectivity may be useful for restoring glucose balance in type 2 diabetes.

TITLE: Lipotoxicity disrupts incretin-regulated human β cell connectivity

AUTHOR CONTACT: David Hodson
Imperial College London, London, , GBR
Phone: 447812029560; E-mail: d.hodson@imperial.ac.uk

View this article at: http://www.jci.org/articles/view/68459?key=b5c05d603bada96f2ee1


ALSO IN THIS ISSUE

TITLE: Proximal Tubule H-Ferritin Mediates Iron Trafficking in Acute Kidney Injury

AUTHOR CONTACT: Anupam Agarwal
U of Alabama @Birmingham, Birmingham, AL, USA
Phone: 2059966670; E-mail: agarwal@uab.edu

View this article at: http://www.jci.org/articles/view/67867?key=d327ac1d4de2473f2135

TITLE: Retinal angiogenesis suppression through small molecule activation of p53

AUTHOR CONTACT: Sai Chavala
The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Phone: 2168490437; E-mail: schavala@med.unc.edu

View this article at: http://www.jci.org/articles/view/67315?key=6b395836741fc796cd8e

TITLE: Thrombospondin-1 mediates oncogenic Ras-induced senescence in pre-malignant lung tumors

AUTHOR CONTACT: Sandra Ryeom
University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Phone: 215-573-5857; Fax: 215-573-2014; E-mail: sryeom@upenn.edu

View this article at: http://www.jci.org/articles/view/67465?key=df1a3976bda4a6a3ad15

TITLE: Perturbation of NK cell peripheral homeostasis accelerates prostate carcinoma metastasis

AUTHOR CONTACT: Jennifer Wu
University of Washington, Seattle, WA, USA
Phone: (206)3415349; Fax: (206)3415302; E-mail: wuj@u.washington.edu

View this article at: http://www.jci.org/articles/view/69369?key=022f7a3c4c93862b248c


'/>"/>

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Related medicine news :

1. KORT Physical Therapy and Healthcare Reform: Early Intervention Drives Costs Down for Patients, Insurance Companies
2. Covance and the Indiana CTSI to collaborate on early clinical research
3. New method for early detection of colon cancer
4. Diet Doc Medical Weight Loss Plans Now Helps Women Lose Weight Fast Before Early Pregnancy to Reduce Risks of Premature Death for their Children
5. Diet Doc Weight Loss Plans Reveals New Fat Loss Diet Pills to Eliminate Fat Before Early Pregnancy Weight Can Affect Future Offspring
6. Early Detection Services at Dedicated Breast Center
7. New screening strategy may catch ovarian cancer at early stages
8. CA-125 change over time shows promise as screening tool for early detection of ovarian cancer
9. PearlyPenilePapules.co.uk Launches an Effective Pearly Penile Papules Removal Service
10. San Diego Dermatologist Discusses Most Effective Treatment for Pearly Penile Papules (PPP)
11. Use of tPA for ischemic stroke nearly doubled from 2003 to 2011
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... ... that offers insurance and financial preparation services, is providing an update on a ... organization. , Rock City Rescue is a locally recognized nonprofit that provides shelter ...
(Date:10/13/2017)... Las Vegas, Nevada (PRWEB) , ... October 13, 2017 , ... ... of 7® Hemp CBD Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum ... CBD dose required and providing a CBD form that can be easily incorporated into ...
(Date:10/13/2017)... ... 13, 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills is ... vendors and unique items from across the nation, this holiday-themed event will raise funds ... by the VNA. The boutique will be open Saturday, November 4 (10:00 a.m. ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader in agile ... a contract by the Center for Medicare and Medicaid Services (CMS). The Enterprise ... use of Agile methodologies in a consistent and high value manner across CMS ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... Planet Fitness, ... the U.S., announced today its plans to open a flagship location in Covington, LA ... the former Rooms To Go store next to Office Depot in the Holiday Square ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2017 The Rebound mobile app is poised to ... the tide of prescription drug addiction. The app empowers users ... and stepping down their dosage in a safe, controlled manner ... 2017; the first 100,000 people to sign up will enjoy ... ...
(Date:9/27/2017)... and NEW YORK , Sept. 27, 2017  DarioHealth ... and big data solutions, today announced that its MyDario product is expected ... local TV listings for when The Dr. Oz Show airs in your ... The nine-time Emmy ... ...
(Date:9/22/2017)... Md. , Sept. 22, 2017  As the ... Republican Senators Bill Cassidy (R-LA) and ... Information notes that the medical device industry is in ... medical device tax, the 2.3% excise tax on medical ... But they also want covered patients, increased visits and ...
Breaking Medicine Technology: