Navigation Links
JCI early table of contents for Sept. 9, 2013

Study identifies fibroblast growth factor 18 as an ovarian cancer biomarker

Ovarian cancer is one of the leading causes of cancer-related death in women and is often not detected until the later stages of disease, which contributes to poor prognosis. Biomarkers that can be used for early diagnosis and outcome have been identified; however, many of these have not been evaluated at the biological and clinical levels. In this issue of the Journal of Clinical Investigation, Michael Birrer and colleagues at Massachusetts General Hospital identify fibroblast growth factor 18 (FGF18) as a predictive marker for poor overall survival in ovarian cancer patients. Overexpression of the gene encoding FGF18 was associated with enhanced tumor blood vessel formation and expression of cancer promoting cytokines. These data indicate that further studies on the predictive potential FGF18 and its use as a therapeutic target in ovarian cancer are warranted.

TITLE: FGF18 as a prognostic and therapeutic biomarker in ovarian cancer

AUTHOR CONTACT: Michael Birrer
Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Phone: 617-724-4800; E-mail:

View this article at:

Insulin secretion disrupted by increased fatty acids

Patients with type 2 diabetes have increased levels of circulating glucose and fatty acids, which lead to disease complications. In healthy individuals, β cells within pancreatic islets release insulin in response to glucose and incretins, which are gastrointestinal hormones. Coordination between β cells is predicted to be important for insulin release. In this issue of the Journal of Clinical Investigation, David Hodson and colleagues at Imperial College London demonstrate that β cell-β cell interactions are important for insulin secretion in human islets and that these interactions are regulated by incretins. The authors found that increased fatty acid levels suppressed incretin-associated insulin release. These findings indicate that therapies aimed at maintaining β cell connectivity may be useful for restoring glucose balance in type 2 diabetes.

TITLE: Lipotoxicity disrupts incretin-regulated human β cell connectivity

Imperial College London, London, , GBR
Phone: 447812029560; E-mail:

View this article at:


TITLE: Proximal Tubule H-Ferritin Mediates Iron Trafficking in Acute Kidney Injury

AUTHOR CONTACT: Anupam Agarwal
U of Alabama @Birmingham, Birmingham, AL, USA
Phone: 2059966670; E-mail:

View this article at:

TITLE: Retinal angiogenesis suppression through small molecule activation of p53

The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Phone: 2168490437; E-mail:

View this article at:

TITLE: Thrombospondin-1 mediates oncogenic Ras-induced senescence in pre-malignant lung tumors

University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Phone: 215-573-5857; Fax: 215-573-2014; E-mail:

View this article at:

TITLE: Perturbation of NK cell peripheral homeostasis accelerates prostate carcinoma metastasis

University of Washington, Seattle, WA, USA
Phone: (206)3415349; Fax: (206)3415302; E-mail:

View this article at:


Contact: Corinne Williams
Journal of Clinical Investigation

Related medicine news :

1. KORT Physical Therapy and Healthcare Reform: Early Intervention Drives Costs Down for Patients, Insurance Companies
2. Covance and the Indiana CTSI to collaborate on early clinical research
3. New method for early detection of colon cancer
4. Diet Doc Medical Weight Loss Plans Now Helps Women Lose Weight Fast Before Early Pregnancy to Reduce Risks of Premature Death for their Children
5. Diet Doc Weight Loss Plans Reveals New Fat Loss Diet Pills to Eliminate Fat Before Early Pregnancy Weight Can Affect Future Offspring
6. Early Detection Services at Dedicated Breast Center
7. New screening strategy may catch ovarian cancer at early stages
8. CA-125 change over time shows promise as screening tool for early detection of ovarian cancer
9. Launches an Effective Pearly Penile Papules Removal Service
10. San Diego Dermatologist Discusses Most Effective Treatment for Pearly Penile Papules (PPP)
11. Use of tPA for ischemic stroke nearly doubled from 2003 to 2011
Post Your Comments:
(Date:10/13/2017)... LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for care ... is the 90-day elimination period, when the family pays for care, is often waived, ...
(Date:10/13/2017)... NJ (PRWEB) , ... October 13, 2017 , ... Global ... at scenic Alexandria Park in Milford, NJ. This free event, sponsored by Global ... physical activity. The fun run is geared towards children of all ages; it ...
(Date:10/13/2017)... ... 13, 2017 , ... Coveros, a leader in agile coaching ... contract by the Center for Medicare and Medicaid Services (CMS). The Enterprise Agile ... of Agile methodologies in a consistent and high value manner across CMS programs. ...
(Date:10/12/2017)... WILMINGTON, Del. (PRWEB) , ... October 12, 2017 ... ... technology and advisory services for healthcare compliance program management, will showcase a range ... and National Association for Assisted Living (NCAL) Convention and Expo to be held ...
(Date:10/12/2017)... ... 2017 , ... The company has developed a suite of ... authorities worldwide. From Children’s to Adults 50+, every formula has been developed by ... , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, Non-Dairy*, Preservative ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... , Oct. 2, 2017  Eli Lilly and ... financial results for the third quarter of 2017 on ... conference call on that day with the investment community ... The conference call will begin at 9 ... can access a live webcast of the conference call ...
(Date:9/28/2017)... Hill-Rom Holdings, Inc. (NYSE: HRC), will host ... webcast on Friday, November 3, 2017, beginning at 7:00 ... approximately 8:30 a.m. (CDT) / 9:30 a.m. (EDT). ... performance and guidance for 2018, Hill-Rom executives will also ... performance, and long-range financial outlook through 2020. ...
(Date:9/25/2017)... , Sept. 25, 2017   Montrium ... Master File solutions, today—from the IQPC Trial Master ... , NL)—announced that EastHORN Clinical Services has ... clinical programs and TMF management. EastHORN, a leading ... eTMF platform to increase transparency to enable greater ...
Breaking Medicine Technology: