Navigation Links
JCI early table of contents for Sept. 16, 2013
Date:9/16/2013

Researchers identify a metabolite as a biomarker of diabetes risk

Type 2 diabetes (T2D) is the most common form of diabetes and is associated with many complications. T2D is preventable through weight control and exercise; however, many individuals are unaware that they are at risk and do not change their lifestyle in time to avoid disease. In this issue of the Journal of Clinical Investigation, Robert Gerszten and colleagues at Massachusetts General Hospital identify the metabolite 2-aminoadipic acid (2-AAA) as a biomarker for T2D diabetes risk. Individuals with increased levels of 2-AAA had a much greater risk of developing diabetes than individuals with lower 2-AAA levels. The authors found that this metabolite was present in at-risk individuals up to 12 years before to T2D onset. Additionally, addition of 2-AAA to isolated pancreatic cells from both mice and humans enhanced insulin secretion. This study provides a biomarker of T2D risk that is a potential therapeutic target for the regulation of glucose homeostasis.

TITLE: 2-Aminoadipic acid is a biomarker for diabetes risk

AUTHOR CONTACT: Robert E. Gerszten
Massachusetts General Hospital, Charlestown, MA, USA
Phone: 617-724-8322; Fax: 617-726-1544; E-mail: RGERSZTEN@PARTNERS.ORG

View this article at: http://www.jci.org/articles/view/64801?key=174fdbca12771be4333b


Genotype influences muscle performance

Elite endurance athletes commonly have mutations that result in the loss of the protein α-actinin-3, which is a major component of fast-twitch muscle fibers. Loss of α-actinin-3 is associated with reduced power, increased endurance capacity, and enhanced response to endurance training. In this issue of the Journal of Clinical Investigation<
'/>"/>

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Early Registration Deadline on Monday for U.S. Conference on Rare Diseases and Orphan Products
2. After Taking Diabetes Drug Actos for Nearly Seven Years, Florida Man Developed Bladder Cancer, Alleges Lawsuit Filed by Parker Waichman LLP
3. Contract Research Organization WCCT Global Announces Acquisition of Early Phase Ophthalmology and Aesthetics Capabilities
4. Medicaid pays for nearly half of all births in the United States
5. JCI early table of contents for Sept. 9, 2013
6. KORT Physical Therapy and Healthcare Reform: Early Intervention Drives Costs Down for Patients, Insurance Companies
7. Covance and the Indiana CTSI to collaborate on early clinical research
8. New method for early detection of colon cancer
9. Diet Doc Medical Weight Loss Plans Now Helps Women Lose Weight Fast Before Early Pregnancy to Reduce Risks of Premature Death for their Children
10. Diet Doc Weight Loss Plans Reveals New Fat Loss Diet Pills to Eliminate Fat Before Early Pregnancy Weight Can Affect Future Offspring
11. Early Detection Services at Dedicated Breast Center
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... Dallas, Texas (PRWEB) July 13, 2014 ... of aGVHD in the 6MM, from 8,062 diagnosed incident ... 2023, at an Annual Growth Rate (AGR) of 4.35%, ... have the highest number of diagnosed incident cases of ... whereas Spain will have the lowest number of diagnosed ...
(Date:7/13/2014)... 13, 2014 According to the Kidney Disease ... step by step guide on what to do to eliminate ... quickly. Vkool writes in its review that readers can easily ... to revitalize their kidney health. Vkool also informs in its ... reverse their damaged kidney functions naturally. The book consists of ...
(Date:7/13/2014)... Hills, California (PRWEB) July 13, 2014 ... Danny Musico has formed a promotional partnership with Aqua ... plant based Omega-3 EPA supplement . The collaboration ... is a celebrity fitness trainer , actor, model, ... Hollywood’s go-to trainer for A-List celebrities, he has prepared ...
(Date:7/13/2014)... Ann Arbor, MI (PRWEB) July 13, 2014 ... online learning program he has just launched at http://www.HealthYourself101.com ... management of visceral obesity. , Power has set out ... and its ill effects that’s actually – dare we say ... , “The program,” says Power, “aims to engage the remote ...
(Date:7/13/2014)... Recently, iFitDress.com, one of the most ... outfits, has added a new selection of beautiful ... has launched a promotion for these evening gowns. Now, ... is now providing thousands of graceful gowns in its ... Britain, America, France, Italy and many other countries. They ...
Breaking Medicine News(10 mins):Health News:Graft-Versus-Host Disease Market (GVHD) Growing at 4.35% AGR to 2023 Says a New Report Available at ReportsnReports.com 2Health News:Graft-Versus-Host Disease Market (GVHD) Growing at 4.35% AGR to 2023 Says a New Report Available at ReportsnReports.com 3Health News:Graft-Versus-Host Disease Market (GVHD) Growing at 4.35% AGR to 2023 Says a New Report Available at ReportsnReports.com 4Health News:Kidney Disease Solution Book Review Exposes Duncan Capicchiano's Newly Updated Kidney Disease Treatment Plan – Vkool.com 2Health News:Kidney Disease Solution Book Review Exposes Duncan Capicchiano's Newly Updated Kidney Disease Treatment Plan – Vkool.com 3Health News:Celebrity Fitness Expert Supports Revolutionary New Health Supplement 2Health News:Retired Ann Arbor Physician and Professor Wields New Media to Teach Health Science 2Health News:Retired Ann Arbor Physician and Professor Wields New Media to Teach Health Science 3Health News:Retired Ann Arbor Physician and Professor Wields New Media to Teach Health Science 4Health News:New and Beautiful Evening Dresses Unveiled by iFitDress.com 2
... , , MILWAUKEE, July 16 ... the nation in two different specialties, according to US News and ... same publication, St. Luke,s and Aurora Sinai Medical Center were recognized by ... , , (Logo: ...
... American Association for Homecare Applauds ,Medicare Home Oxygen ... Confusion, Service Disruption, and Reduced Access to Care for More than ... ARLINGTON, Va., July 16 The American Association for Homecare ... the Medicare Home Oxygen Therapy Act of 2009, which would protect ...
... CAMBRIDGE, Mass., July 16 Biopure Corporation (Nasdaq: ... petition for relief under Chapter 11 of the United States Bankruptcy ... Massachusetts. Biopure will continue to manage and operate its businesses ... the supervision of the Bankruptcy Court. , , ...
... , NORCROSS, Ga., July 16 Immucor, ... providing automated instrument-reagent systems to the blood transfusion industry, today ... and Chief Operating Officer. , , ... have worldwide responsibility for manufacturing and distribution as well as ...
... of problems right away, study notes , THURSDAY, July 16 ... soldiers from the Iraq and Afghanistan wars seen at VA ... a new study shows. , Curiously, the researchers from the ... diagnoses were not made in the first year that a ...
... , , NEW YORK and LOS ANGELES, July ... The Cleaner , with Benjamin Bratt starring as ... show,s co-executive producer Warren Boyd. What,s encouraging about The Cleaner ... the nature of addictive behavior. With more than 23 million Americans ...
Cached Medicine News:Health News:Aurora's Milwaukee Hospitals Recognized in US News and World Report 2Health News:Congressmen Mike Ross and Kendrick Meek Introduce Bill to Protect Medicare Patients Who Require Medical Oxygen Therapy at Home 2Health News:Congressmen Mike Ross and Kendrick Meek Introduce Bill to Protect Medicare Patients Who Require Medical Oxygen Therapy at Home 3Health News:Immucor Appoints Chief Operating Officer 2Health News:Many Veterans Need Mental Health Care 2Health News:Many Veterans Need Mental Health Care 3Health News:Many Veterans Need Mental Health Care 4Health News:Coming Clean About The Cleaner - Phoenix House's Chief Clinical Officer David Deitch on Intervention, and the Recovery Process That Follows 2Health News:Coming Clean About The Cleaner - Phoenix House's Chief Clinical Officer David Deitch on Intervention, and the Recovery Process That Follows 3
(Date:7/11/2014)... ANGELES , July 11, 2014 /PRNewswire-iReach/ -- ... e-liquid, a vegetable-glycol solution for use in portable ... of the active ingredients in cannabis, cannabidiol offers ... personal vaporizer devices, and other vaporizer technology. ... Cannabis naturally contains 483 different compounds which ...
(Date:7/11/2014)... -- Research and Markets has announced the ... Film Industry Report 2014" report to their offering. ... Global And Chinese Medical X-Ray Film Industry Report 2014 ... state of the Global medical X-ray film industry with ... provides a basic overview of the industry including definitions, ...
(Date:7/11/2014)... , July 11, 2014  Australian drug delivery company, ... it has raised A$19.3 million via a placement of ... , the U.S., Asia ... from a share purchase plan (SPP) to be offered ... be made in two tranches. "This capital ...
Breaking Medicine Technology:VAPETEK Releases CBD-Infused eLiquid For The Consumer Market 2Global and Chinese Medical X-ray Film Industry Report 2014 2Phosphagenics' A$19.3 million Capital Raising 2Phosphagenics' A$19.3 million Capital Raising 3
... Inc. ( www.spirusmed.com ), a leading developer of diagnostic ... of pan-endoscopies in an average time of 60 minutes, ... power a single use spiral component. The initial clinical ... ability to navigate the intestinal tract. ...
... Cantel Medical Corp. (NYSE: CMN ), announced ... medical face masks - the SecureFit™ series by Crosstex ... of medical face masks. The SecureFit™ series of masks ... as a major hindrance to their effectiveness.  Medical face ...
Cached Medicine Technology:Recent Patient Series Demonstrates Spirus Medical's Power Spiral Endoscope Enables Unprecedented Access to GI Tract 2Recent Patient Series Demonstrates Spirus Medical's Power Spiral Endoscope Enables Unprecedented Access to GI Tract 3Cantel Medical Corp. Launches New Medical Face Mask Addressing Issue of Fit 2Cantel Medical Corp. Launches New Medical Face Mask Addressing Issue of Fit 3
Inquire...
Legionella provides rapid, accurate results that aid in the presumptive diagnosis of Legionella infection (Legionnaires' Disease)....
... The advanced design of the ... its sleek, modern configuration, now ... color to complement any office ... designed to integrate into existing ...
The AP250 Auto Projector is a remote-controlled, programmable, random-access, high-resolution, ophthalmic projector....
Medicine Products: