Navigation Links
JCI early table of contents for Nov. 26, 2012
Date:11/26/2012

is a tightly regulated process that is sensitive to the balance of the proteins that form hemoglobin, heme and globin. The protein FLVCR1a is responsible for removing excess heme from cells and is essential for erythropoiesis. In this issue of the Journal of Clinical Investigation, researchers led by Emanuela Tolosano at the University of Torino in Italy identified another form of FLVCR1, FLVCR1b, that is responsible for exporting heme from the mitochondria of the cell, the location of heme production. By manipulating the expression of the FLVCR1 proteins in mice, Tolosano and colleagues found that FLVCR1b was required for erythropoiesis. FLVCR1a was not required for erythropoiesis, but was necessary to prevent excess bleeding, swelling, and skeletal abnormalities in the developing mouse embryo. These results indicate that mutations in the Flvcr1 gene may underlie diseases characterized by abnormal heme levels, such as Sideroblastic anemia. In a companion commentary, Mark Fleming of Children's Hospital Boston discusses the role of heme transport in human physiology and disease.

TITLE:
The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation

AUTHOR CONTACT:
Emanuela Tolosano
University of Torino, Torino, UNK, ITA
Phone: 39-011-670-6423; Fax: 39-011-670-6432; E-mail: emanuela.tolosano@unito.it

View this article at: http://www.jci.org/articles/view/62422?key=da4e860633582101d3cb

ACCOMPANYING COMMENTARY

TITLE:
Mitochondrial heme: an exit strategy at last

AUTHOR CONTACT:
Mark Fleming
Children's Hospital Boston, Boston, MA, USA
Phone: 617-919-2664; E-mail: mark.fleming@childrens.harvard.edu

View this article at:

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10

Related medicine news :

1. New Stool Test Might Aid in Early Detection of Colon Cancer
2. An Early Start for Your Child with Autism
3. Early Study Finds Some Promise for Lung Cancer Vaccine
4. Treat Rheumatoid Arthritis Early and Aggressively: Guidelines
5. JCI early table of contents for April 9, 2012
6. Eye Tremors May Aid Early Diagnosis of Parkinsons: Study
7. Nearly 1 in 4 grandparents store prescription medicines where children can easily find them
8. First contact: Early intervention key in diagnosis and treatment of serious mental illness
9. Brain Tumor Vaccine Shows Promise in Early Trial
10. Role of Screening, Monitoring in Early Kidney Disease Unclear
11. Detecting malaria early to save lives: New optical technique promises rapid and accurate diagnosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/21/2014)... FL (PRWEB) December 21, 2014 When families ... lice, who do they call? The new answer is ... Coral Gables FL 33134, their newest treatment center will be ... pest quickly, conveniently and without the use of harmful chemicals ... is scheduled for January 1, 2015. Like the company’s first ...
(Date:12/21/2014)... New York, New York (PRWEB) December 21, 2014 ... http://www.byettalawsuit2013.com/ ) and other product liability claims involving ... as incretin mimetics continue to move forward in ... District Court, Southern District of California, Bernstein Liebhard ... 17th, the Court has established a data cut-off ...
(Date:12/21/2014)... Recently, one of the best prom dresses online shops ... introduced its new collection of 2015 prom dresses, and ... its prom dresses & other fashionable designs, up to ... quality dress products and great customer services to its ... the best prom dresses online shops around the world ...
(Date:12/21/2014)... Muskegon, Mi (PRWEB) December 21, 2014 ... a child in need while at the same time helping ... is a non-profit community-based organization committed to serving those ... to meet their needs to improve the quality of life. ... would make an impact in the local community and he ...
(Date:12/21/2014)... Parker & Sons, Inc. a market leader ... other similar home contractor services announces a record number ... expert contracting services. The company is considered by many ... Arizona for well over 40 years. Parker and Sons ... quality customer service to the residents and business owners ...
Breaking Medicine News(10 mins):Health News:All-Natural Florida Lice Removal Company Opens New Lice Treatment Salon In South Florida 2Health News:Byetta Lawsuit News: New Order Issued in Federal Incretin Mimetics Litigation, Bernstein Liebhard LLP Report 2Health News:Byetta Lawsuit News: New Order Issued in Federal Incretin Mimetics Litigation, Bernstein Liebhard LLP Report 3Health News:Byetta Lawsuit News: New Order Issued in Federal Incretin Mimetics Litigation, Bernstein Liebhard LLP Report 4Health News:New Prom Dresses From One Of The Best Prom Dresses Online Shops, LunaDress Prom Shop 2Health News:AlignLife of Norton Shores Makes a Brighter Christmas for Kids in Muskegon 2Health News:Parker & Sons Announces Record Number Of Favorable Reviews In 2014 With Regard To Its Expert Contracting Services 2Health News:Parker & Sons Announces Record Number Of Favorable Reviews In 2014 With Regard To Its Expert Contracting Services 3
... Richard Gephardt and the Council for American Medical Innovation ... Chicago, featuring David Brennan, CEO of AstraZeneca, David Miller, ... CHICAGO, April 15 Today in Chicago, the "Best ... national leaders in academia, biotechnology and patient advocacy to ...
... experts call for Americans to go "Meatless" on MondaysNEW YORK, ... both in April, health and environmental advocates are calling on ... national "meatless" days, as three of his predecessors in office ... .Presidents Wilson, Truman and Roosevelt all instituted national meatless ...
... New web site provides help for growing mental health ... Feel Better Network (FBN) announces the ... , the premiere online resource for individuals who ... of emotional challenges. The FBN mission is to provide ...
... 16 issue of the journal "Neuron," was conducted by scientists ... University School of Medicine, who characterized their finding as "an ... ... (Vocus) April 15, 2009 -- Scientists are ...
... diagnose the disease, , , WEDNESDAY, April 15 (HealthDay ... improve the tracking of changes in cancer cells, ... of Medicine. , The technology uses specially designed ... in or on a single cell. , Current ...
... Tenn., April 15 The Harvard Business ... examines the growth and impact of Youth Villages, ... statewide in North Carolina and has become a ... health in the last decade. (Photo: ...
Cached Medicine News:Health News:Chicago's Top Minds Join National Business and Health Leaders in Addressing Medical Innovation, Highlighting Policies Needed to Maintain U.S. Competitiveness in Medical Science and Discovery 2Health News:Chicago's Top Minds Join National Business and Health Leaders in Addressing Medical Innovation, Highlighting Policies Needed to Maintain U.S. Competitiveness in Medical Science and Discovery 3Health News:Chicago's Top Minds Join National Business and Health Leaders in Addressing Medical Innovation, Highlighting Policies Needed to Maintain U.S. Competitiveness in Medical Science and Discovery 4Health News:Obama Urged to Bring Back National Meatless Program 2Health News:Feel Better Network Launches Web Site for Relief in Challenging Times 2Health News:UCSF, Stanford Study Reveals Neural Networks Targeted in Brain Diseases 2Health News:UCSF, Stanford Study Reveals Neural Networks Targeted in Brain Diseases 3Health News:UCSF, Stanford Study Reveals Neural Networks Targeted in Brain Diseases 4Health News:Harvard Business School Publishes Case Study on Youth Villages in North Carolina 2Health News:Harvard Business School Publishes Case Study on Youth Villages in North Carolina 3Health News:Harvard Business School Publishes Case Study on Youth Villages in North Carolina 4
(Date:12/19/2014)... , Dec. 18, 2014  RESMED INC. (NYSE: ... quarter of fiscal year 2015 results on Thursday, January 22, ... press release with ResMed,s results will be issued after 1:00 ... webcast to discuss operating results and future outlook. ... US Pacific Time and the live webcast of the call ...
(Date:12/19/2014)... China separating membrane market has witnessed robust development ... years, albeit as a later starter. In 2012, the size ... approximated RMB12 billion, with the proportion worldwide soaring to 16.3%. ... membrane market will continue its growth rate by around 20% ... will jump to roughly RMB25 billion. An integrated ...
(Date:12/17/2014)... , Dec. 17, 2014  Northstar Global ... Depository Trust Company (DTC) has made their final ... Chill on the Company,s stock effective December 15, ... common stock for depository and book entry transfer ... Company is now once again fully "DTC Eligible", ...
Breaking Medicine Technology:ResMed To Announce Second Quarter 2015 Results 2Separation Membranes Market (Company, Country & Application) Research Reports for Global and Chinese Regions 2Separation Membranes Market (Company, Country & Application) Research Reports for Global and Chinese Regions 3Northstar announces that the DTC chill on MDIN has been officially lifted 2Northstar announces that the DTC chill on MDIN has been officially lifted 3
... , a Celling Biosciences company that designs, develops ... is pleased to announce the addition of Dr. Matthew Murphy ... joins SpineSmith in the position of Senior Scientist and will ... of autologous stem cells for spine, orthopedics, and cardiovascular therapies. ...
... 2012  Criticare Systems Inc., a global leader in ... supply vital signs monitors to major hospitals in ... part of Russia,s nationwide program to upgrade hospital ... Under the agreement developed by Criticare,s ...
Cached Medicine Technology:SpineSmith Adds Talented Scientist to Research and Development Team 2Criticare Secures Contract to Supply nGenuity Vital Signs Monitors to Russian Hospitals 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: