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JCI early table of contents for Nov. 26, 2012
Date:11/26/2012

nvestigation, researchers led by Kenneth White at Indiana University describe a patient with a chromosomal translocation that results in increased levels of αKlotho. The patient presented with rickets, low blood phosphate and calcium levels, and increased FGF23. To determine how αKlotho effects these changes, White and colleagues over-expressed cKL in mice and found that increased cKL resulted in enhanced FGF23 levels, decreased serum calcium and phosphate levels, low bone mineral content, and bone fractures. These data establish cKL as an important regulator of FGF23 production and phosphate metabolism and may have implications for the treatment of rickets. In a companion commentary, Harald Jppner of Massachusetts General Hospital and Myles Wolf of the University of Miami discuss the role of FGF23 and αKlotho in mineral metabolism.

TITLE:
Circulating αKlotho influences phosphate handling by controlling FGF23 production

AUTHOR CONTACT:
Kenneth E White
Indiana University School of Medicine, Indianapolis, IN, USA

Phone: 317-278-6140; Fax: 317-274-2293; E-mail: kenewhit@iupui.edu

View this article at: http://www.jci.org/articles/view/64986?key=7d8ae8802deff9a3caa3

ACCOMPANYING COMMENTARY

TITLE:
αKlotho: FGF23 coreceptor and FGF23-regulating hormone

AUTHOR CONTACT:
Harald Jppner
Massachusetts Gen Hosp, Boston, MA, USA
Phone: 617-726-3966; Fax: 617-726-7543; E-mail: jueppner@helix.mgh.harvard.edu

View this article at: http://www.jci.org/articles/view/67055?key=97377cc82306b227bcad


USP44 helps cells double check chromosome segregation to prevent cancer '/>"/>

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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