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JCI early table of contents for Nov. 26, 2012
Date:11/26/2012

Bariatric surgery procedures have similar therapeutic benefits in obese adults

Obesity is associated with insulin resistance and type 2 diabetes, both of which can be significantly improved by weight loss. Gastric bypass and adjustable gastric banding are two bariatric surgery techniques that are frequently used to effect weight loss in obese patients, but it is unclear if the two procedures produce different outcomes. In this issue of the Journal of Clinical Investigation, researchers led by Samuel Klein at the University of Washington School of Medicine in St. Louis compared the effects of 20% weight loss induced by either gastric bypass or adjustable gastric banding on metabolic response. They found that patients had different metabolic responses after eating, but both procedures equally improved insulin sensitivity and glucose tolerance. The researchers concluded that weight loss itself is primarily responsible for the therapeutic effects of gastric bypass and adjustable gastric banding in non-diabetic obese adults.

TITLE:
Gastric bypass and banding equally improve insulin sensitivity and β-cell function

AUTHOR CONTACT:
Samuel Klein
Washington University School of Medicine, St Louis, MO, USA
Phone: 314-362-8708; E-mail: sklein@dom.wustl.edu

View this article at: http://www.jci.org/articles/view/64895?key=31c84cf8f52f834d9914

Identifying the cause of anesthesia-induced seizures

Antifibrinolytic drugs are frequently used to prevent blood loss during surgery, but sometimes cause convulsive seizures. In this issue of the Journal of Clinical Investigation, researchers led by Beverly Orser at the University of Toronto investigated the molecular mechanisms that underlie this side effect. By studying antifibrinolytics in m
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Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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