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JCI early table of contents for Nov. 19, 2012
Date:11/19/2012


Hans-Christian von Bdingen
University of California, San Francisco, San Francisco, CA, USA
Phone: +1- 415-476-9046; Fax: +1-415-476-5229; E-mail: Hans-christian.Vonbuedingen@ucsf.edu

View this article at: http://www.jci.org/articles/view/63842?key=c2030e1d3315891dd835


Viperin protects against Chikungunya virus

Chikungunya virus (CHIKV) is a mosquito-borne virus that causes fever and severe joint pain. It is occurring with increasing frequency in Africa, Asia, and the Indian sub-continent, but there are not any treatments for the disease. The human immune system can eventually repel the virus; however, the immune response mechanisms are undefined. In a study published in the Journal of Clinical Investigation, researchers led by Lisa Ng at the Singapore Immunology Network examined the immune cells of human Chikungunya patients. They found that the expression of the protein viperin increased significantly in monocytes, the cells that are primarily targeted by CHIKV. Viperin attenuated viral replication and mice lacking viperin had a greater viral load and more severe joint inflammation compared to normal mice. These data demonstrate that virperin is a critical host protein that controls CHIKV infections and suggest that therapeutics that modulate viperin may be useful in treating similar viruses.

TITLE:
Viperin restricts chikungunya virus replication and pathology

AUTHOR CONTACT:
Lisa F.P. Ng
Singapore Immunology Network, Singapore, SGP
Phone: +6564070028; E-mail: lisa_ng@immunol.a-star.edu.sg

View this article at: http://www.jci.org/articles/view/63120?key=53eb96677e427a77b8d1


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Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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