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JCI early table of contents for Nov. 19, 2012
Date:11/19/2012

emorial Sloan-Kettering Cancer Center, New York, NY, USA
Phone: 646-888-2304; Fax: 917-432-2375; E-mail: vandenbm@mskcc.org

View this article at: http://www.jci.org/articles/view/60630?key=f4013c21c2eed05dbc54


Treating muscle weakness in myotopic dystrophy

Myotopic Dystrophy type 1 (DM1), also known as Steinert disease, is a congenital neuromuscular disease characterized by wasting of the muscle, muscle weakness, endocrine changes, and cognitive problems. It is caused by the insertion of nucleotide repeats in the DMPK gene. In this issue of the Journal of Clinical Investigation, researchers led by Lubov Timchenko at Baylor College of Medicine used a mouse model of DM1 to identify dysregulated signaling pathways that contribute to disease progression. Timchenko and colleagues found that GSK3β signaling was increased in DM1 mice and that inhibition of GSK3β reduced muscle weakness and wasting. These results suggest that therapies that normalize GSK3β activity may help improve muscle function in DM1 patients.

TITLE:
GSK3β mediates muscle pathology in myotonic dystrophy

AUTHOR CONTACT:
Lubov Timchenko
Baylor College of Medicine - BCM 315, Houston, TX, USA
Phone: 713 798 6911; E-mail: lubovt@bcm.tmc.edu

View this article at: http://www.jci.org/articles/view/64081?key=3a6f408e3f25b9e3c14c


HIV-1 infection generates microparticles that kill immune cells

HIV-1 disables the immune system, leaving patients susceptible to viral and bacterial infections. Dendritic cells (DCs) are a population of immune cells that are involved in controlling HIV infection, leading Nina Bhardwaj and resea
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Contact: Jillian Hurst
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Journal of Clinical Investigation
Source:Eurekalert

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