Navigation Links
JCI early table of contents for Nov. 19, 2012
Date:11/19/2012

s immune cells from the peripheral blood were found to be defective in their ability to migrate. Interestingly, the immune cell defects were apparent prior to the onset of HD symptoms. This study suggests that changes in immune cell function may underlie some of the symptoms of HD.

TITLE:
Mutant huntingtin impairs immune cell migration in Huntington disease

AUTHOR CONTACT:
Paul Muchowski
J. David Gladstone Institutes, San Francisco, CA, USA
Phone: 415-734-2515; E-mail: pmuchowski@gladstone.ucsf.edu

View this article at: http://www.jci.org/articles/view/64484?key=ed9b525e3a43db3e13d8

T cell development remains intact after loss of thymic function

Bone marrow transplant (BMT) patients and the elderly suffer from a loss of thymic function, resulting in low T cell production and greater susceptibility to infection. Several previous studies have indicated that T cells can develop outside the thymus; however, it is unclear if these cells are fully functional. In this issue of the Journal of Clinical Investigation, researchers led by Marcel van den Brink at Memorial Sloan-Kettering Hospital used a mouse model of BMT to determine if extrathymic T cell development could produce functional T cells. Van den Brink and colleagues found that mice with impaired thymic function after BMT produced fully functional T cells, demonstrating that lymph nodes can support T cell development in the absence of thymic function. These results suggest that patients with limited thymic function can still produce functional T cells and that these pathways could be therapeutically targeted to enhance functional T cell populations.

TITLE:
Extrathymic development of murine T cells after bone marrow transplantation

AUTHOR CONTACT:
Marcel R.M. van den Brink
M
'/>"/>

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

0

GOOD

Page: 1 2 3 4 5 6 7

Related medicine news :

1. Gene Distinguishes Early Birds from Night Owls and Helps Predict Time of Death
2. Early Menstruation Tied to Factors That Raise Heart Disease Risk
3. Early 50s may be key time to reach baby boomers with health messages
4. Early Exposure to Stress at Home Affects Girls Brains, Study Says
5. JCI early table of contents for Nov. 12, 2012
6. Predrinking Nearly Doubles Booze Consumption: Study
7. Early treatment sparks striking brain changes in autism
8. Imaging speeds early diagnosis of heart disease, the top killer in the Western world
9. JCI early table of contents for Nov. 1, 2012
10. Meth vaccine shows promising results in early tests
11. Radiation treatment after surgery improves survival for elderly women with early-stage breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/19/2013)... 2013 The Pradaxa lawyers at Bernstein ... recently convened for hundreds of Pradaxa bleeding ... in U.S. District Court, Southern District of Illinois. ... May 14th, the Conference addressed the status of depositions ... the Conference that Defendants submitted a list of early ...
(Date:5/19/2013)... (PRWEB) May 19, 2013 Farming methods ... seed in the ground 10,000 years ago. Most recently, ... farm productivity by using genetically engineered seeds and by ... seeing a backlash to these techniques due to the ... chemicals and a corresponding surge in interest in organic, ...
(Date:5/19/2013)... Seattle, WA (PRWEB) May 19, 2013 The ... updated weight loss secrets that help people get ... age, gender, and body shape. The program also is a ... loss diet plans. Besides, the author of this fat loss ... body transformation program, which can help people keep body fat ...
(Date:5/19/2013)... Yeast infections are common in both men and women. These ... body. A new yeast infection treatment product has been released ... of application to help eliminate over growth of the candida ... and women searching for a natural process of yeast elimination. ... and is stored in the intestines. In small consumable doses, ...
(Date:5/19/2013)... (PRWEB) May 19, 2013 Exciting new ... who is reintroducing a great practice known through the ... also known as dry body brushing, has so many ... founder of Sublime Beauty®. "We love that circulation and ... our largest organ, the skin, is supported through Skin ...
Breaking Medicine News(10 mins):Health News:Pradaxa Lawyers at Bernstein Liebhard LLP Report on Recent Status Conference in Federal Pradaxa Litigation 2Health News:Pradaxa Lawyers at Bernstein Liebhard LLP Report on Recent Status Conference in Federal Pradaxa Litigation 3Health News:Green Acre Aquaponics Introduces a Revolutionary Approach to Farm Education and Commercial Aquaponics 2Health News:Green Acre Aquaponics Introduces a Revolutionary Approach to Farm Education and Commercial Aquaponics 3Health News:Weight Loss Secrets | How “The Fat Loss Code” Helps People Gain A Healthy Life And Get In Shape - Health Review 2Health News:A Safe & Homeopathic Yeast Infection Relief by Yeastrol Now Available at HealthCareSupplementz.com with Massive Discount 2Health News:Exciting New Skin Brushes at Sublime Beauty® Bring Health and Beauty Benefits; Celebrities and Models Know the Secret 2
... use of incense increases the risk of developing cancers of ... analysis, which the authors say is the first prospective investigation ... 2008 issue of CANCER, a peer-reviewed journal of ... of daily life in large parts of Asia. Researchers have ...
... Mich., Aug. 22 Stryker Corporation,(NYSE: SYK ) ... conferences:, September 3, 2008 - 9:45 a.m. ... Boston, Massachusetts, September 17, 2008 - 9:30 ... 2008 London, England, Simultaneous webcasts of the ...
... reduce unhealthy behaviors like binge drinking and eating junk ... But a new study in the Journal of Consumer ... to improve consumer health. , Authors Jonah Berger ... that linking a risky behavior with an "outgroup" (a ...
... hotel towels if they know other guests are doing ... Journal of Consumer Research examined participation rates in ... Authors Noah J. Goldstein (University of Chicago), Robert B. ... that the types of signs posted in hotel bathrooms ...
... Technology approved for control of food-borne pathogens in ... Robert Brackett, chief,science officer for the Grocery ... response to the U.S. Food & Drug,Administration (FDA) ... for,controlling food-borne pathogens in fresh iceberg lettuce and ...
... use eRx Network Medicare Part B transaction ... processing services in its stores nationwide, FORT WORTH, Texas, ... transaction services to the retail pharmacy,industry, announced today that it ... Part B claims, state,Medicaid DME claims and clinical administration programs ...
Cached Medicine News:Health News:Burning incense increases risk of respiratory tract cancers 2Health News:Stryker to Present at Investor Conferences 2Health News:Part of the in-group? A surprising new strategy helps reduce unhealthy behaviors 2Health News:A room with a viewpoint: conservation messages and motivation 2Health News:Grocery Manufacturers Association Strongly Supports U.S. Food & Drug Administration Decision on the Irradiation of Fresh Produce for Foodborne Pathogen Control 2Health News:eRx Network to Provide Transaction Processing and Revenue Cycle Management Services to Rite Aid 2
(Date:5/17/2013)... -- Medical devices are any medical items that are ... of their different mechanisms, actions and regulatory requirements, medical ... drug trails due to their unique clinical practices. Currently, ... both safety and efficacy (which is left to the ... as the SFDA) evaluate MDs for both safety and ...
(Date:5/17/2013)... SAN DIEGO and CAMBRIDGE, Mass., May 17, 2013 ... announce that a purchaser of Aveo Pharmaceutical, Inc. (NASDAQGS: ... District Court for the District of Massachusetts ... of its officers violated the Securities Exchange Act of ... May 1, 2013 (the "Class Period"). (Logo: ...
(Date:5/17/2013)... , May 17, 2013  TechAtlas Group ... for their competitive landscape map for the Chronic ... over 90 international companies with drugs and devices ... CKD and its sequelae. (Logo:  ... , hypertension - renal denervation ...
Breaking Medicine Technology:Statistical Challenges in Medical Device Trail Evaluation 2Aveo Pharmaceuticals, Inc. Sued by Investor 2Aveo Pharmaceuticals, Inc. Sued by Investor 3TechAtlas Group Releases Innovative Chronic Kidney Disease Landscape Map 2
... the power of clinical information. , ... of clinical connectivity solutions that help you ... high-quality patient care. You will have access ... to share it with your care team ...
... monitoring for intermediate care., ,The S/5 FM ... Datex-Ohmeda S/5 product line., ,The S/5 FM ... power to grow. The new Patient Side Module ... up to 12-lead ECG, NIBP, motion-tolerant SpO ...
... solution for advanced arrhythmia analysis, ... one compact, PC-based solution for both ... connects to Datex-Ohmeda Network and supports ... 16 beds., ,The S/5 Arrhythmia ...
... with wireless connectivity, ,The wireless functionality ... monitoring system that makes it possible to ... to the S/5 Central Station via Wireless ... flexible way of providing continuous centralized surveillance ...
Medicine Products: