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JCI early table of contents for Nov. 19, 2012
Date:11/19/2012

s immune cells from the peripheral blood were found to be defective in their ability to migrate. Interestingly, the immune cell defects were apparent prior to the onset of HD symptoms. This study suggests that changes in immune cell function may underlie some of the symptoms of HD.

TITLE:
Mutant huntingtin impairs immune cell migration in Huntington disease

AUTHOR CONTACT:
Paul Muchowski
J. David Gladstone Institutes, San Francisco, CA, USA
Phone: 415-734-2515; E-mail: pmuchowski@gladstone.ucsf.edu

View this article at: http://www.jci.org/articles/view/64484?key=ed9b525e3a43db3e13d8


T cell development remains intact after loss of thymic function

Bone marrow transplant (BMT) patients and the elderly suffer from a loss of thymic function, resulting in low T cell production and greater susceptibility to infection. Several previous studies have indicated that T cells can develop outside the thymus; however, it is unclear if these cells are fully functional. In this issue of the Journal of Clinical Investigation, researchers led by Marcel van den Brink at Memorial Sloan-Kettering Hospital used a mouse model of BMT to determine if extrathymic T cell development could produce functional T cells. Van den Brink and colleagues found that mice with impaired thymic function after BMT produced fully functional T cells, demonstrating that lymph nodes can support T cell development in the absence of thymic function. These results suggest that patients with limited thymic function can still produce functional T cells and that these pathways could be therapeutically targeted to enhance functional T cell populations.

TITLE:
Extrathymic development of murine T cells after bone marrow transplantation

AUTHOR CONTACT:
Marcel R.M. van den Brink
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Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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