Date:11/12/2012

adenocarcinoma is a highly invasive form of lung cancer that is associated with a decrease in a gene regulatory protein known as NKX2-1. In a study published in the Journal of Clinical Investigation, researchers led by Jeffrey Whitsett at Cincinnati Children's Hospital demonstrated that loss of one copy of the Nkx2-1 gene and the expression of an activated form of the oncogene Kras caused mucinous adenocarcinoma in mice. Interestingly, loss of one copy of Nkx2-1 in combination with the expression of another common lung-cancer associated gene, Egfr, did not cause carcinogenesis. These results suggest that the function of Nkx2-1 is context dependent and indicate that the genotype of mucinous adenocarcinomas should influence the choice of treatment.

TITLE:
KRAS.G12D and NKX2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung

AUTHOR CONTACT:
Jeffrey Whitsett
Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
Phone: 513-803-2790; E-mail: jeff.whitsett@cchmc.org

View this article at: http://www.jci.org/articles/view/64048?key=45dd78d39619f78e0fd9

'/>"/>

Contact: Jillian Hurst press_releases@the-jci.org Journal of Clinical Investigation Source:Eurekalert

0 GOOD

Page: 1 2 3 4 5 6 7
Related medicine news :

1. Predrinking Nearly Doubles Booze Consumption: Study
2. Early treatment sparks striking brain changes in autism
3. Imaging speeds early diagnosis of heart disease, the top killer in the Western world
4. JCI early table of contents for Nov. 1, 2012
5. Meth vaccine shows promising results in early tests
6. Radiation treatment after surgery improves survival for elderly women with early-stage breast cancer
7. ESDM early intervention improves brain activity associated with social cues
8. Mayo Clinic researchers develop new tools to better treat ADHD patients in early stages
9. Short-Term, Early HRT May Cut Womens Alzheimers Risk: Study
10. Simple ovarian cancer symptom survey that checks for 6 warning signs may improve early detection
11. Nearly half of kidney recipients in live donor transplant chains are minorities