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JCI early table of contents for Nov. 12, 2012
Date:11/12/2012

adenocarcinoma is a highly invasive form of lung cancer that is associated with a decrease in a gene regulatory protein known as NKX2-1. In a study published in the Journal of Clinical Investigation, researchers led by Jeffrey Whitsett at Cincinnati Children's Hospital demonstrated that loss of one copy of the Nkx2-1 gene and the expression of an activated form of the oncogene Kras caused mucinous adenocarcinoma in mice. Interestingly, loss of one copy of Nkx2-1 in combination with the expression of another common lung-cancer associated gene, Egfr, did not cause carcinogenesis. These results suggest that the function of Nkx2-1 is context dependent and indicate that the genotype of mucinous adenocarcinomas should influence the choice of treatment.

TITLE:
KRAS.G12D and NKX2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung

AUTHOR CONTACT:
Jeffrey Whitsett
Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
Phone: 513-803-2790; E-mail: jeff.whitsett@cchmc.org

View this article at: http://www.jci.org/articles/view/64048?key=45dd78d39619f78e0fd9


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Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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