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JCI early table of contents for Nov. 12, 2012
Date:11/12/2012

g.kyushu-u.ac.jp">yusaku@bioreg.kyushu-u.ac.jp

View this article at: http://www.jci.org/articles/view/65053?key=c5b0174a10a6a76d0f4e


Mob mentality: loss of the protein MOB1 causes uncontrolled cell growth

Cancer is caused by an imbalance in the signals that tell cells to grow or differentiate into a specialized cell type. The Hippo signaling pathway, which regulates growth signals, is frequently mutated or inactivated in many human cancers, including trichilemmal carcinoma, a cancer that originates in hair follicles. The protein MOB1 is also frequently mutated in trichilemmal carcinoma; however its role in carcinogenesis is unclear. In a study published in the Journal of Clinical Investigation researchers led by Akira Suzuki at Kyushu University in Fukuoka, Japan investigated the role of MOB1 in Hippo signaling. Using mice with deletions or mutations in the Mob1 gene, Suzuki and colleagues found that loss of Mob1 in skin cells caused uncontrolled cell growth through dysregulation of the Hippo signaling pathway. This study establishes MOB1 as a tumor suppressor and suggests that therapeutics targeting the Hippo pathway or MOB1 might be useful in the treatment of Hippo-driven cancers, including trichilemmal carcinoma.

TITLE:
Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice

AUTHOR CONTACT:
Akira Suzuki
Div.Cancer Genetics,Medical Institute of Bioregulation,Kyushu Univ., Fukuoka, UNK, JPN
Phone: +81-92-642-6835; Fax: +81-92-632-1499; E-mail: suzuki@bioreg.kyushu-u.ac.jp

View this article at: http://www.jci.org/articles/view/63735?key=f60115dbaf1d103d8a48


A context dependent role for Nkx2-1 in lung cancer

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Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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