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JCI early table of contents for Nov. 12, 2012
Date:11/12/2012

actor that stimulates the proliferation of M2 macrophages, increased injury and delayed recovery. This study demonstrates that CSF1 plays a critical role in the recovery of the renal tubules following AKI.

TITLE:
CSF-1 signaling mediates recovery from acute kidney injury

AUTHOR CONTACT:
Raymond C. Harris
Vanderbilt University Med Center, Nashville, TN, USA
Phone: 615 322-2150; E-mail: ray.harris@vanderbilt.edu

View this article at: http://www.jci.org/articles/view/60363?key=00e3d82b49b94040100b

Neurodegeneration is triggered by DNA repair

Oxidative metabolism produces reactive oxygen species (ROS), highly toxic molecules that cause DNA and tissue damage. The brain is particularly susceptible to ROS damage and excessive ROS, a condition known as oxidative stress, can lead to neurodegeneration. In a study published in the Journal of Clinical Investigation, researchers led by Yusaku Nakabeppu at Kyushu University in Fukuoka, Japan investigated the role of a ROS-induced DNA lesion, 8-oxoguanine, in neurodegeneration. Nakabeppu and colleagues engineered mice that lacked different DNA repair enzymes to determine if the DNA lesion could activate cell death pathways in neurons. They found that the accumulation of 8-oxoguanine activated cell death pathways in neurons and the neuron-supporting glial cells upon repair of the DNA lesion. These findings indicate that suppression of specific DNA repair enzymes may protect the brain under conditions of oxidative stress.

TITLE:
8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair

AUTHOR CONTACT:
Yusaku Nakabeppu
Medical Institute of Bioregulation, Kyushu University, Fukuoka, , JPN
Phone: +81-92-642-6800; Fax: +81-92-642-6791; E-mail:

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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