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JCI early table of contents for Nov. 12, 2012
Date:11/12/2012

f North Carolina at Chapel Hill, Chapel Hill, NC, USA
Phone: 919.966.1683; Fax: 919.843.4576; E-mail: malangacj@neurology.unc.edu

View this article at: http://www.jci.org/articles/view/61888?key=1a28adee2b0b4c806d9d


A new view of the immune system

Immune responses take place throughout the body and require the correct migration of particular subsets of immune cells to precise locations. In a study published in the Journal of Clinical Investigation, researchers led by Andreas Beilhack at Wrzburg University in Germany report the development of a microscopy technique that allows for the visualization of individual immune cells in intact tissues and organs. The technique, called Light Sheet Fluorescence Microscopy (LSFM), was used to monitor T-cell responses in the intestines and in mice after a bone marrow transplant. This new technology will provide insight into complex immune processes.

TITLE:
Mapping immune processes in intact tissues at cellular resolution

AUTHOR CONTACT:
Christian Brede
Wrzburg University Clinics, Wrzburg, , DEU
Phone: +49-931-201-27638; E-mail: Brede_C@medizin.uni-wuerzburg.de

View this article at: http://www.jci.org/articles/view/65100?key=c11733018bb267aa0cf3


Unraveling the role of the unfolded protein response in cancer

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers a cellular stress response known as the Unfolded Protein Response (UPR), which supports cell survival. UPR is activated at a higher frequency in mouse and human lymphomas, suggesting that it might contribute to the survival of cancer cells. In a study published in t
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Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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