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JCI early table of contents for Nov. 12, 2012
Date:11/12/2012

Home field advantage: Intravaginal immunization may help protect against infection

Sexually-transmitted diseases (STDs) enter the body through the mucosal epithelial cells and the ability to direct pathogen-clearing T-cells to points of infection may be the critical element in developing successful vaccines against these infections. In a study published in the Journal of Clinical Investigation, researchers led by John Schiller at the National Cancer Institute investigated the immune response to intravaginal immunization in mice infected with a form of the HPV virus carrying a model antigen. They found that intravaginal immunization significantly increased the number of immune cells present in the vaginal mucosa compared with a general immune system booster. These results indicate that site-specific vaccination enhances the local immune system response and may be useful in developing STD vaccines.

TITLE:
Intravaginal immunization with HPV vectors induces tissue-resident CD8+ T cells

AUTHOR CONTACT:
John Schiller
National Cancer Institute, Bethesda, MD, USA
Phone: 301-594-2715; Fax: 301-480-5322; E-mail: schillej@dc37a.nci.nih.gov

View this article at: http://www.jci.org/articles/view/63287?key=95b0c2a37738d68fcd61


HIV-1 vaccine development: pinning down a moving target

HIV-1 is a genetically diverse collection of viruses, making it a moving target in vaccine development. In a study published in the Journal of Clinical Investigation, researchers led by Brad Jones at the University of Toronto in investigated the feasibility of eliminating HIV-infected cells by targeting cellular immune responses against a human endogenous retrovirus (HERV). HERVs are the DNA remnants of ancient infectious retroviruses that became part of the germ line cell
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Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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